Estrogen receptor gene polymorphism in a Chinese population with multiple sclerosis

作     者：Qingli Sun Ruping Xie Yu Fu Xiaogang Li Dongsheng Fan 

作者机构：Department of Neurology Peking University Third Hospital Beijing 100191 China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第19期

页      面：1488-1492页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 0905[农学-畜牧学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090501[农学-动物遗传育种与繁殖] 090102[农学-作物遗传育种] 

基　　金：the National Natural Science Foundation of China  No. 81071148 

主　　题：estrogen receptor gene polymorphism multiple sclerosis case-control study 

摘      要：This study sought to elucidate the role of the Pvull and Xbal polymorphisms of the estrogen receptor gene in 74 Chinese patients with multiple sclerosis, and 95 ethnicity-matched controls, using polymerase chain reaction-restriction fragment-length polymorphism analysis. The results revealed that the P allele of Pvull was significantly more prevalent in multiple sclerosis patients compared with controls （P = 0.019）. While distribution frequencies were significantly increased in female multiple sclerosis patients compared with female controls （P = 0.044）, no significant difference was observed between male patients and controls （P〉 0.05）. Frequencies of Ppxx genotypes were significantly higher in multiple sclerosis patients compared with controls （24.3% vs 12.8%, P = 0.025）. Genotypes and alleles of the estrogen receptor were not associated with age, number of attacks or expanded disability status scale scores of patients with multiple sclerosis. These findings indicate that the Pvull but not the Xbal polymorphism in the estrogen receptor gene is associated with susceptibility to multiple sclerosis in the Chinese population. In addition, women with P allele appear to be particularly susceptible to multiple sclerosis.