Correlation of molecular alterations with pathological features in hepatocellular carcinoma:Literature review and experience of an Italian center
作者机构：Department of ExperimentalDiagnostic and Specialty MedicineUniversity of BolognaBologna 40138Italy Solid Tumor Molecular Pathology LaboratoryIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of PathologyIRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Department of Pharmacy and biotechnology(FaBiT)University of BolognaBologna 40138Italy
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第25期
页 面：2854-2866页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Hepatocarcinoma Mutation Next-generation sequencing Review TP53 CTNNB1 TERT
摘 要：Hepatocellular carcinoma(HCC)represents the primary carcinoma of the liver and the fourth leading cause of cancer-related *** World Health Organization estimates an increase in cases in the coming *** risk factors of HCC are multiple,and the incidence in different countries is closely related to the different risk factors to which the population is *** molecular mechanisms that drive HCC tumorigenesis are extremely complex,but understanding this multistep process is essential for the identification of diagnostic,prognostic,and therapeutic *** development of multigenic nextgeneration sequencing panels through the parallel analysis of multiple markers can provide a landscape of the genomic status of the *** the literature and our preliminary data based on 36 HCCs,the most frequently altered genes in HCCs are TERT,CTNNB1,and *** the years,many groups have attempted to classify HCCs on a molecular basis,but a univocal classification has never been ***,statistically significant correlations have been found in HCCs between the molecular signature and morphologic features,and this leads us to think that it would be desirable to integrate the approach between anatomic pathology and molecular laboratories.
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