In silico modelling of the corrosion of biodegradable magnesium-based biomaterials:modelling approaches,validation and future perspectives

作     者：Aditya Joshi George Dias Mark P.Staiger 

作者机构：Department of Mechanical EngineeringUniversity of CanterburyChristchurchNew Zealand Department of AnatomyUniversity of OtagoDunedinNew Zealand 

出 版 物：《Biomaterials Translational》 (生物材料转化电子杂志（英文）)

年 卷 期：2021年第2卷第3期

页      面：257-271页

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：supported by the Health Research Council of New Zealand 

主　　题：biomaterial biodegradation corrosion finite element method magnesium modelling 

摘      要：Metallic biomedical implants based on magnesium,zinc and iron alloys have emerged as bioresorbable alternatives to permanent orthopaedic implants over the last two *** corrosion rate of biodegradable metals plays a critical role in controlling the compatibility and functionality of the device in *** broader adoption of biodegradable metals in orthopaedic applications depends on developing in vitro methods that accurately predict the biodegradation behaviour in ***,the physiological environment is a highly complex corrosion environment to replicate in the laboratory,making the in vitro-to-in vivo translation of results very ***,the results from in vitro corrosion tests fail to provide a complete schema of the biodegradation behaviour of the metal in *** silico approach based on computer simulations aim to bridge the observed differences between experiments performed in vitro and vivo.A critical review of the state-of-the-art of computational modelling techniques for predicting the corrosion behaviour of magnesium alloy as a biodegradable metal is presented.