The role of rumen epithelial urea transport proteins in urea nitrogen salvage:A review

作     者：Chongliang Zhong Ruijun Long Gavin S.Stewart Chongliang Zhong;Ruijun Long;Gavin S.Stewart

作者机构：College of EcologyState Key Laboratory of Grassland Agro-ecosystemsLanzhou UniversityLanzhouChina School of Biology and Environmental ScienceUniversity College DublinDublinIreland 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2022年第9卷第2期

页      面：304-313页

核心收录：

学科分类：090601[农学-基础兽医学] 09[农学] 0906[农学-兽医学] 

基　　金：China Postdoctoral Science Foundation(2021M701532) National Natural Science Foundation of China(32072757) 

主　　题：Urea nitrogen salvaging Rumen Urea transporter Aquaporin UT-B AQP 

摘      要：The symbiotic relationship between the host and the rumen microbiome plays a crucial role in ruminant *** of the most important processes enabling this relationship is urea nitrogen salvaging(UNS).This process is important for both maintaining ruminant nitrogen balance and supporting production of their major energy supply,bacterially-derived short chain fatty acids(SCFA).The key step in UNS is the trans-epithelial movement of urea across the ruminal wall and this is a highly regulated *** the molecular level,the key transport route is via the facilitative urea transporter-B2,localized to ruminal papillae epithelial *** urea transport through aquaporins(AQP),such as AQP3,is now also viewed as ***-term regulation of these ruminal urea transport proteins appears to mainly involve dietary fermentable carbohydrates;whereas,transepithelial urea transport is finely regulated by local conditions,such as CO_(2) levels,pH and SCFA *** the key principles of ruminal urea transport physiology are now understood,there remains much that is unknown regarding the regulatory *** reason for this is the limited number of techniques currently used in many studies in the ***,future research in this area that combines a greater range of techniques could facilitate improvements to livestock efficiency,and potentially,reductions in the levels of waste nitrogen entering the environment.