Discussion on the mechanism of the calcium absorption in the human body

作     者：ZHANG Jingkun ZHANG Zemin YU Ao 

作者机构：Central LaboratoryNankai UniversityTianjin 300071China Department of ChemistryNankai UniversityTianjin 300071China 

出 版 物：《Chinese Science Bulletin》 (中国科学通报)

年 卷 期：2001年第46卷第16期

页      面：1403-1408页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

主　　题：amino acid chelate calcium. 

摘      要：The present article discusses a new mechanism of calcium absorption in the human body. The mechanism is revealed as follows. First, after food is digested in the stomach, calcium ions (Ca2+) are released. The small intestine secretes amino acid or short peptide chain with small molecular weight automatically, which are called chelating agent; when the calcium ions from the stomach get to the small intestine, the reaction of the chelating agent with the calcium ions occurs, producing the neutral amino acid calcium chelate. Then, this kind of calcium chelate with small molecular weight is absorbed as a whole into the tissues of the small intestine. After being absorbed, in the cell the calcium chelate can break down its chelating bond automatically and decompose into the amino acid and calcium ion again. Finally, the calcium ion goes into blood through portal vein and is transferred to the organs and also deposits on the bone. The reason for the body抯 calcium insufficiency, which has no linear relation with the calcium intake amount, is the lack of the amino acid secreted by the small intestine. The main barrier that influences the calcium absorption is anion pollution. The calcium absorptivity of the body has nothing to do with the solubility of the calcium source out of the body. A new kind of calcium supplement agent——glycine calcium chelate——is synthesized, whose molecular weight is 206.06 (containing a molecular water). If the glycine calcium chelate is used to make calcium supplement agent, about 20 mg calcium element (converted from the glycine calcium chelate, the same below, no longer indicated) per day for one person, 50 mg at most, is enough to maintain the positive balance of calcium metabolism.