Protective effects of tumor necrosis factor α antibody and ulinastatin on liver ischemic reperfusion in rats
Protective effects of tumor necrosis factor α antibody and ulinastatin on liver ischemic reperfusion in rats作者机构：DepartmentofHepatobiliarySurgery.XijingHospitalFourthMilitaryMedicalUniversityXi'an710032.ShaanxiProvince.China DepartmentofGeneralSurgeryZhujiangHospitalFirstMilitaryMedicalUniversityGuangzhou510282GuangdongProvince.China DepartmentofHepatobiliarySurgery.XijingHospitalFourthMilitaryMedicalUniversityXi'an710032.ShaanxiProvince.China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2004年第10卷第21期
页 面：3161-3164页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by the National Natural Science Foundation of China No.30070741
主 题：保护作用 肿瘤坏死因子 α抗体 肝脏 血液灌注 老鼠 TNFα 肝纤维化
摘 要：AIM: To study the protective effects of tumor necrosis factor α (TNFα) antibody and ulinastatin on liver ischemic reperfusion in ***: One hundred and twenty male SD rats were randomly divided into four groups: normal control group, ischemic group, TNFα antibody group and TNFα antibody + ulinastatin group. The animals were killed at 0, 3, 6, 9, 12 h after ischemia for 60 min and followed by reperfusion. Serum alanine aminotransferase (ALT), malondialdehyde (MDA) and liver histopathology were ***: After ischemic reperfusion, the serum ALT and MDA were remarkably increased, and the hepatic congestion was obvious. Treatment of TNFα antibody and ulinastatin could significantly decrease serum ALT and MDA levels, and relieve hepatic ***: Ulinastatin and TNFα antibody can suppress the inflammatory reaction induced by hepatic ischemic reperfusion, and have protective effects on rat hepatic ischemic reperfusion injury.
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