SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

作     者：Yiming Shao Yingqi Wu Yi Feng Wenxin Xu Feng Xiong Xinxin Zhang Yiming Shao;Yingqi Wu;Yi Feng;Wenxin Xu;Feng Xiong;Xinxin Zhang

作者机构：Chinese Center for Disease Control and PreventionBeijing 102206China Changping LaboratoryBeijing 102206China Department of Infectious DiseasesResearch Laboratory of Clinical VirologyNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Policy ScienceCentral Committee of the Chinese Peasants and Workers Democratic PartyBeijing 100011China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2022年第16卷第2期

页      面：185-195页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(No.U20A20362) 

主　　题：COVID-19 pandemics SARS-CoV-2 vaccination 

摘      要：The record speed at which Chinese scientists identified severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and shared its genomic sequence with the world,has greatly facilitated the development of coronavirus disease(COVID-19)diagnostics,drugs,and *** is unprecedented in pandemic control history to develop a dozen successful vaccines in the first year and to immunize over half of the global population in the second year,due to the efforts of the scientific community,biopharmaceutical industry,and regulatory agencies *** challenges are both great and multidimensional due to the rapid emergence of virus variants and waning of vaccine *** strategies need to adapt to these challenges to keep population immunity above the herd immunity threshold,by increasing vaccine coverage,especially for older adults and young people,and providing timely booster doses with homologous or heterologous vaccine *** research should be undertaken to develop more effective vaccines against SARS-CoV-2 variants and to understand the best prime-boost vaccine combinations and immunization strategies to provide sufficient and sustainable immune protection against COVID-19.