Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV

作     者：Jingjing Hu Ling Gu Yueming Shao Renfang Zhang Tangkai Qi Jianjun Sun Zhenyan Wang Wei Song Yang Tang Jiangrong Wang Shuibao Xu Junyang Yang Yinzhong Shen Li Liu Jun Chen Hongzhou Lu 

作者机构：School of Public HealthBengbu Medical CollegeBengbu233000AnhuiChina Department of Infectious Diseases and ImmunologyShanghai Public Health Clinical CenterFudan University2901 Caolang RoadJinshan DistrictShanghai201508China Shenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen518000China 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2022年第11卷第1期

页      面：47-55页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Shanghai Commission of Science and Technology(20MC1920100 and 21Y11901200) Shanghai key Infectious Disease Project(shslczdzk01102) Shanghai Municipal Health Commission(GWV-10.1-XK02) development fund for Shanghai talents(2020089) Shanghai "Rising stars of Medical Talent" Youth Development Program(No. 2019-72) 

主　　题：HIV/AIDS Nontuberculous mycobacteria Case-fatality rate Risk factor 

摘      要：Background:Few data are available regarding the long-term case-fatality rate(CFR)among people living with HIV(PLWH)with nontuberculous mycobacteria(NTM)*** aim of this study is to analyze the long-term CFR in patients with NTM disease and to identify risk factors for their ***:A retrospective cohort study of 379 cases of microbiologically confirmed NTM disease in PLWH was conducted from January 1,2012,to December 31,2020,in Shanghai,*** used Kaplan-Meier survival analysis and the log-rank test to compare the long-term CFR in patients with disseminated NTM(DNTM)and localized NTM *** Cox proportional hazards regression analysis and a stepwise Cox proportional hazards regression model were used to estimate the predictors of long-term ***:The cohort was followed up for a median of 26 *** total CFR was 15.7%by one year and increased to 22.6%at 5 years after the diagnosis of NTM *** 5-year CFR of PLWH with DNTM was significantly higher than that of PLWH with localized NTM(26.7%vs 19.6%for DNTM and localized NTM disease,respectively).Older age[hazard ratio(HR)=1.04,95%confidence interval(CI):1.02-1.06,P0.001],comorbidity(HR=2.05,95%CI:1.21-3.49,P0.01),DNTM(HR=2.08,95%CI:1.17-3.68,P0.05),and HIV viral load(HR=1.32,95%CI:1.12-1.55,P0.001)were all independent risk factors for long-term *** the subgroup analysis,time to culture positivity was negatively correlated with CFR in patients with DNTM(HR=0.90,95%CI:0.82-0.98,P0.05).Conclusions:NTM was associated with a high long-term CFR in *** approaches to prevent NTM disease in PLWH are urgently needed.