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Drug resistance and pathogenic spectrum of patients coinfected with nontuberculous mycobacteria and human-immunodeficiency virus in Chengdu, China

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Chinese Medical Journal 2019年第11期132卷 1293-1297页

作者： Dong-Mei Wang Yi Liao Qing-Feng Li Ma Zhu Gui-Hui Wu Yuan-Hong Xu Jing Zhong Jia Luo Ying-Jie Li Department of Clinical Laboratory Public Health Clinical Center of Chengdu Chengdu Sichuan 610066 China Department of Clinical Laboratory Chengdu Woman's and Children's Central Hospital Chengdu Sichuan 610073 China

Background:Human-immunodeficiency virus (HIV) infection is increasing worldwide and nontuberculous mycobacteria (NTM) is an established microbiologic cause of pulmonary disease,lymphadenitis,and disseminated disease in cases of advanced immune *** on patients coinfected with HIV and NTM are ***,this study aimed to analyze the clinical characteristics,drug resistance,and pathogen spectrum of patients coinfected with both HIV and NTM in the Chengdu area of ***:Data of 59 patients coinfected with both HIV and NTM collected from the Public Health Clinical Center of Chengdu,between January 2014 and December 2018,were *** drug sensitivity testing was performed using the microporous plate ratio *** were analyzed using SPSS 19.0,and the change in drug resistance rate was analyzed using the chi-square (x2) ***:Seven species/complex of NTM were identified from patients coinfected with HIV and NTM in this study,with Mycobacterium avium-intracellulare complex (52.5%) and *** (27.1%) as the predominant *** patients were more affected 50/59 (84.7%);the mean age of the 59 cases was 45 *** clinical characteristics mainly included anemia (86.4%),cough and expectoration (79.7%).The baseline CD4 count was 0.05).Condusions:The immune level of patients coinfected with HIV and NTM is low in advanced AIDS stage;more male are

关键词： Clinical features Drug resistance HIV Mycobacterium avium-intracellulare infection Mycobacterium kansasii nontuberculous mycobacteria

Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV

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Infectious Diseases of Poverty 2022年第1期11卷 47-55页

作者： Jingjing Hu Ling Gu Yueming Shao Renfang Zhang Tangkai Qi Jianjun Sun Zhenyan Wang Wei Song Yang Tang Jiangrong Wang Shuibao Xu Junyang Yang Yinzhong Shen Li Liu Jun Chen Hongzhou Lu School of Public Health Bengbu Medical CollegeBengbu233000AnhuiChina Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan University2901 Caolang RoadJinshan DistrictShanghai201508China Shenzhen Third People’s Hospital The Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen518000China

Background:Few data are available regarding the long-term case-fatality rate(CFR)among people living with HIV(PLWH)with nontuberculous mycobacteria(NTM)*** aim of this study is to analyze the long-term CFR in patients with NTM disease and to identify risk factors for their ***:A retrospective cohort study of 379 cases of microbiologically confirmed NTM disease in PLWH was conducted from January 1,2012,to December 31,2020,in Shanghai,*** used Kaplan-Meier survival analysis and the log-rank test to compare the long-term CFR in patients with disseminated NTM(DNTM)and localized NTM *** Cox proportional hazards regression analysis and a stepwise Cox proportional hazards regression model were used to estimate the predictors of long-term ***:The cohort was followed up for a median of 26 *** total CFR was 15.7%by one year and increased to 22.6%at 5 years after the diagnosis of NTM *** 5-year CFR of PLWH with DNTM was significantly higher than that of PLWH with localized NTM(26.7%vs 19.6%for DNTM and localized NTM disease,respectively).Older age[hazard ratio(HR)=1.04,95%confidence interval(CI):1.02-1.06,P<0.001],comorbidity(HR=2.05,95%CI:1.21-3.49,P<0.01),DNTM(HR=2.08,95%CI:1.17-3.68,P<0.05),and HIV viral load(HR=1.32,95%CI:1.12-1.55,P<0.001)were all independent risk factors for long-term *** the subgroup analysis,time to culture positivity was negatively correlated with CFR in patients with DNTM(HR=0.90,95%CI:0.82-0.98,P<0.05).Conclusions:NTM was associated with a high long-term CFR in *** approaches to prevent NTM disease in PLWH are urgently needed.

关键词： HIV/AIDS nontuberculous mycobacteria Case-fatality rate Risk factor

Molecular Epidemiology of nontuberculous Mycobacteria in a German CF Center and Clinical Course of NTM Positive Patients

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Open Journal of Medical Microbiology 2013年第1期3卷 39-47页

作者： Carolin Kroner Barbara Ganster Matthias Kappler Ann-Christin Grimmelt Bernd H.Belohradsky Michael Hogardt Gudrun Laniado Michael Meissner Soren Schubert Matthias Griese Paediatric Pneumology Dr.von Hauner Children’s HospitalLudwig-Maximilians-UniversityMunichGermany Institute for Clinical Chemistry Molecular DiagnosticsMedical Microbiology and Hygiene DepartmentLudwigshafen General HospitalLudwigshafenGermany Institute for Medical Microbiology and Infection Control University HospitalJohann-Wolfgang-Goethe-UniversityFrankfurt/MainGermany Max von Pettenkofer Institute of Hygiene and Medical Microbiology Ludwig-Maximilians-UniversityMunichGermany

Goal of this study was to analyse the clinical course of cystic fibrosis (CF) patients with nontuberculous mycobacteria (NTM) in their respiratory secretions and to investigate the molecular epidemiology of the most prevalent NTM species by multilocus sequence analysis (MLSA). The respiratory specimen and the clinical parameters forced expiratory volume in one second (FEV1), body-mass-index (BMI), erythrocyte sedimentation rate (ESR) 1 h and immunoglobulin G (IgG) of 357 CF patients, 0 - 52.4 years, mean FEV1 2009 81.5% pred were analysed between 1998 and 2010. In 13 patients NTM were detected. 12 of 13 patients carried M. abscessus, for one patient the NTM species was not characterized. 4 patients carried a second NTM species (M. avium, M. chelonae (2x), M. intracellulare). 6 patients exhibited a significant decline in FEV1, however changes in BMI, IgG and ESR were discordant. Molecular genotyping of M. abscessus isolates revealed a unique MLSA pattern in 6 patients. 2 patients harboured identical strains, and one patient a closely related strain. Whether the presence of identical strains is attributed to the acquisition of NTM clones from common environmental sources or to patient-to-patient transmission cannot be definitely clarified. Although cross-in- fection of the three patients with identical/closely related strains in the present cohort is highly unlikely, we recommend strict hygiene measures for all CF patients harbouring NTM.

关键词： Mycobacteria nontuberculous Mycobacterium abscessus Cystic Fibrosis Molecular Epidemiology Multilocus Sequence Analysis(MLSA) Interferon Gamma

Cervical nontuberculous Mycobacterial Lymphadenitis Mimicking a Thyroid Tumor and Infiltrating Deep into the Neck

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Surgical Science 2012年第12期3卷 561-563页

作者： Kazuhiro Mino Tadao Okada Shouhei Honda Hisayuki Miyagi Nobuhisa Ishiguro Kanako C. Kubota Taketomi Akinobu Department of Gastroenterological Surgery I Hokkaido University Graduate School of Medicine Sapporo Japan Department of Pediatrics Hokkaido University Graduate School of Medicine Sapporo Japan Department of Surgical Pathology Hokkaido University Hospital Sapporo Japan

Aim: nontuberculous Mycobacterial Lymphadenitis (NML), which occurs in 1.2 per 100,000 children, is very rare. And those which emerge at the anterior cervical portion and infiltrate deep into the neck are even more rare. Generally, this disorder is uncommon existed near the thyroid gland. We report here a case of NML mimicking a thyroid tumor and infiltrating into the deep part of the anterior neck. Case: A mass at the anterior portion of her neck was found at 5 years old. It was not mobile and palpated as an irregularly surfaced hard mass whose size was 3 cm at the anterior lower portion of her neck. Ultrasonography showed an oval mass which existed near the slightly inferior part of the right lobe of the thyroid gland. Enhanced computed tomography showed a mass near the slightly inferior part of the right lobe of the thyroid gland. The mass was resected with the platysma and the right sternohyoid muscle. In the HE staining, epithelioid cell and Langhans type giant cells surrounding coagulative necrosis lesions which seemed to be caseation necrosis existed, similarly to cervical NML. Discussion: No consensus exists for the treatment of NML, but many documents advise complete excision. When the lesion cannot be completely removed, excision as far as possible and additional antibiotics are recommended. The characteristics of imaging of NML around the thyroid gland and infiltrating deep into the anterior neck and mediastinum are discussed.

关键词： Anterior Cervical Portion Mediastinum nontuberculous Mycobacterial lymphadenitis Thyroid Gland

Susceptibility Testing of <i>Mycobacterium frederiksbergense</i>Strains Isolated from Alfalfa Plants against Antibacterial Compounds

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Open Journal of Medical Microbiology 2015年第2期5卷 90-96页

作者： Mirkaveh Mousaviehzadeh Soroush Sardari Drug Design and Bioinformatics Unit Medical Biotechnology Department Biotechnology Research Center Pasteur Institute of Iran Tehran Iran

Mycobacteria constitute vast population of bacteria that are found in animals, plants and outer environments. Tuberculosis mycobacteria are a group that causes very dangerous diseases for human and animals. nontuberculous mycobacteria are mainly environmental and are pathogenic in certain circumstances. There are reports of finding mycobacteria in plant tissues, which can be effective to survey in case of different infectious disease issues. In a previous study, we found mycobacteria strains in alfalfa vascular tissues and identified them to species level using 16S rRNA gene sequence analysis, causing some symptoms in plant tissues and aerial parts. As these rapidly growing mycobacteria (RGM) have the potential to cause opportunistic infections in human tissues, one of the most important issues for dealing with these agents is to find the best and most effective drug to treat them. Here, we conducted some assays to investigate the MIC of 7 antibiotics and two antibacterial agents against eight Mycobacterium frederiksbergense alfalfa isolated strains, in order to find the susceptible and resistant ones. We performed susceptibility testing based on broth microdilution method using Mueller hinton broth as the medium used. Results were different among the strains and different resistant and susceptible reactions were observed among different strains against each drug tested, but ethambutol resulted in similar high MIC for all of them. This variability could be attributed to many factors, such as plant tissue composition and developmental stage from which the strains have been isolated, existence and nature of drug targets and other factors such as test conditions and environmental causes. These results can bring us some insights into design and develop new drugs for treating these kinds of organisms, based on the variations in susceptibility reactions and the plant composition effect on them.

关键词： nontuberculous mycobacteria Opportunistic Infections Mycobacterium frederiksbergense Broth Microdilution