High mobility group box protein 1 and white matter injury following traumatic brain injury: perspectives on mechanisms and therapeutic strategies

作     者：Ronak Ved Susruta Manivannan Imogen Tasker Malik Zaben Ronak Ved;Susruta Manivannan;Imogen Tasker;Malik Zaben

作者机构：The BRAIN UnitNeuroscience and Mental Health Research Institute(NMHRI)School of MedicineCardiff UniversityCardiffUK School of Biomedical SciencesUniversity of BirminghamBirminghamUK 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第8期

页      面：1739-1740页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：BRAIN Unit (Brain Repair and Intracranial Neurotherapeutics Unit) at Cardiff University Health Research Wales MRC [MR/W000679/1] Funding Source: UKRI 

主　　题：injuries injury consequences 

摘      要：Traumatic brain injury(TBI)is a major cause of morbidity and mortality *** significant medical advances over recent decades,many survivors of TBI develop long term neuro-cognitive ***,only moderate and severe injuries were thought to account for the devastating consequences of ***,there is increasing evidence that even milder injuries may result in problematic lifelong cognitive and affective *** is typically characterized by an an acute physical injury followed by a protracted innate neuro-inflammatory *** reponses,mediated via neuronal,astrocyte and microglial cells,amongst others,and may result in widespread neuronal death and a micro-environment that is not conducive to brain repair(Manivannan et al.,2021).Whilst the primary physical injury often evades intervention from a medical perspective,the subsequent neuro-inflammatory response offers a potential therapeutic ***,effective pharmacological strategies continue to elude clinicians and scientists due to the complex underlying pathogenesis and difficulties of modelling such a heterogeneous ***,the majority of research to date has focused on investigating the effects of post-traumatic neuro-inflammation on grey matter injury rather than the consequences upon white matter(WM),which contributes greatly to cognitive dysfunction across many neurological diseases(Filly and Kelly,2018).Herein,we will briefly discuss:(i)high mobility group box protein 1(HMGB1)as a potential therapeutic target;(ii)the relevance of WM injury in TBI and current understanding of WM repair following injury;and(iii)perspectives on how HMGB1 may play a role.