Propofol induces ferroptosis and inhibits malignant phenotypes of gastric cancer cells by regulating miR-125b-5p/STAT3 axis
作者机构:Department ofAnesthesiologyFirst Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of GastroenterologyHeilongjiang Forest Industry Federation(Red Cross)HospitalHarbin 150008Heilongjiang ProvinceChina
出 版 物:《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志(英文版)(电子版))
年 卷 期:2021年第13卷第12期
页 面:2114-2128页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 100217[医学-麻醉学] 10[医学]
主 题:Gastric cancer Progression Ferroptosis Propofol miR-125b-5p STAT3
摘 要:BACKGROUND Gastric cancer is a common malignancy with poor prognosis,in which ferroptosis plays a crucial function in its *** is a widely used anesthetic and has antitumor potential in gastric ***,the effect of propofol on ferroptosis during gastric cancer progression remains *** To explore the function of propofol in the regulation of ferroptosis and malignant phenotypes of gastric cancer *** MTT assays,colony formation assays,Transwell assays,wound healing assay,analysis of apoptosis,ferroptosis measurement,luciferase reporter gene assay,and quantitative reverse transcription polymerase chain reaction were used in this *** Our data showed that propofol was able to inhibit proliferation and induce apoptosis of gastric cancer ***,propofol markedly repressed the invasion and migration of gastric cancer ***,propofol enhanced the erastin-induced inhibition of growth of gastric cancer ***,propofol increased the levels of reactive oxygen species,iron,and Fe2+in gastric cancer ***,propofol suppressed signal transducer and activator of transcription(STAT)3 expression by upregulating miR-125b-5p and propofol induced ferroptosis by targeting STAT3 in gastric cancer *** miR-125b-5p inhibitor or STAT3 overexpression reversed propofol-attenuated malignant phenotypes of gastric cancer *** Propofol induced ferroptosis and inhibited malignant phenotypes of gastric cancer cells by regulating the miR-125b-5p/STAT3 *** may serve as a potential therapeutic candidate for gastric cancer.