Amorphous calcium magnesium phosphate nanocomposites with superior osteogenic activity for bone regeneration
作者机构：Department of OrthopedicSpinal Pain Research InstituteShanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Institute of Translational MedicineShanghai UniversityShanghai 200444China National Engineering Research Center for NanotechnologyShanghai 200241China Institute of Functional Nano&Soft Materials(FUNSOM)Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2021年第8卷第6期
页 面：249-259页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 10[医学]
基 金：support from the National Natural Science Foundation of China(31771081) the Science and Technology Commission of Shanghai Municipality(19441901900,19ZR1439700,19JC1414300)and S&T Innovation 2025 Major Special Programme of Ningbo(2018B10040)are gratefully acknowledged sponsored by Shanghai Pujiang Program(2020PJD045) supported by China Postdoctoral Science Foundation(2019M661630)
主 题：biomineralization bone materials synthesize biomaterial-cell
摘 要：The seek of bioactive materials for promoting bone regeneration is a challenging and longterm *** with inorganic metal ions or drug molecules is considered effective strategies to improve the bioactivity of various existing ***,amorphous calcium magnesium phosphate(ACMP)nanoparticles and simvastatin(SIM)-loaded ACMP(ACMP/SIM)nanocomposites were developed via a simple co-precipitation *** physiochemical property of ACMP/SIM was explored using transmission electron microscope(TEM),Fourier transform infrared spectroscopy(FTIR),powder X-ray diffraction(XRD)and highperformance liquid chromatograph(HPLC),and the role of Mg^(2+) in the formation of ACMP/SIM was revealed using X-ray absorption near-edge structure(XANES).After that,the transformation process of ACMP/SIM in simulated body fluid(SBF)was also tracked to simulate and explore the in vivo mineralization performance of *** find that ACMP/SIM releases ions of Ca^(2+),Mg^(2+)and PO_(4)^(3),when it is immersed in SBF at 37℃,and a phase transformation occurred during which the initially amorphous ACMP turns into self-assembled hydroxyapatite(HAP).Furthermore,ACMP/SIM displays high cytocompatibility and promotes the proliferation and osteogenic differentiation of MC3T3-E1 *** the in vivo studies,lamellar ACMP/SIM/Collagen scaffolds with aligned pore structures were prepared and used to repair a rat defect model in ***/SIM/Collagen scaffolds show a positive effect in promoting the regeneration of calvaria defect after *** bioactive ACMP/SIM nanocomposites are promising as bone repair *** the facile preparation process and superior in vitro/vivo bioactivity,the as-prepared ACMP/SIM would be a potential candidate for bone related biomedical applications.
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