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Amorphous calcium magnesium phosphate nanocomposites with superior osteogenic activity for bone regeneration

Regenerative biomaterials 2021年第6期8卷 249-259页

作者： Yingying Jiang Shuo Tan Jianping Hu Xin Chen Feng Chen Qianting Yao Zhi Zhou Xiansong Wang Zifei Zhou Yunshan Fan Junjian Liu Yize Lin Lijia Liu Shisheng He Department of Orthopedic Spinal Pain Research InstituteShanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China Institute of Translational Medicine Shanghai UniversityShanghai 200444China National Engineering Research Center for Nanotechnology Shanghai 200241China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Shanghai Key Laboratory of Tissue Engineering Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

The seek of bioactive materials for promoting bone regeneration is a challenging and longterm *** with inorganic metal ions or drug molecules is considered effective strategies to improve the bioactivity of various existing ***,amorphous calcium magnesium phosphate(ACMP)nanoparticles and simvastatin(SIM)-loaded ACMP(ACMP/SIM)nanocomposites were developed via a simple co-precipitation *** physiochemical property of ACMP/SIM was explored using transmission electron microscope(TEM),Fourier transform infrared spectroscopy(FTIR),powder X-ray diffraction(XRD)and highperformance liquid chromatograph(HPLC),and the role of Mg^(2+) in the formation of ACMP/SIM was revealed using X-ray absorption near-edge structure(XANES).After that,the transformation process of ACMP/SIM in simulated body fluid(SBF)was also tracked to simulate and explore the in vivo mineralization performance of *** find that ACMP/SIM releases ions of Ca^(2+),Mg^(2+)and PO_(4)^(3),when it is immersed in SBF at 37℃,and a phase transformation occurred during which the initially amorphous ACMP turns into self-assembled hydroxyapatite(HAP).Furthermore,ACMP/SIM displays high cytocompatibility and promotes the proliferation and osteogenic differentiation of MC3T3-E1 *** the in vivo studies,lamellar ACMP/SIM/Collagen scaffolds with aligned pore structures were prepared and used to repair a rat defect model in ***/SIM/Collagen scaffolds show a positive effect in promoting the regeneration of calvaria defect after *** bioactive ACMP/SIM nanocomposites are promising as bone repair *** the facile preparation process and superior in vitro/vivo bioactivity,the as-prepared ACMP/SIM would be a potential candidate for bone related biomedical applications.

关键词： biomineralization bone materials synthesize biomaterial-cell

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