孕16～21周的人绒毛膜促性腺激素水平及其对先兆子痫的预测
Human chorionic gonadotropin levels between 16 and 21 weeks of pregnancy and prediction of pre-eclampsia作者机构：Unidad de Investigació n Clnica Torreó n Coahuila Mexico
出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)
年 卷 期：2006年第2卷第5期
页 面：54-55页
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
主 题：先兆子痫 妊娠中期 经孕妇 初孕妇 阳性似然比 阴性预测值 阳性预测值 界值 特征曲线 特异度
摘 要：To determine whether levels of beta human choriogonadotropin (β - hCG) during the second trimester are a predictor of pre-eclampsia. Methods. A prospective study of 784 women was conducted between their 16th and 20th week of pregnancy. Primigravidas and multigravidas were analyzed separately, and the cutoff point was determined using a receiver operating characteristic curve. The accuracy of β - hCG levels in the prediction of preecla-mpsiawas evaluated. The likelihood ratios were calculated for different levels of β - hCG in both groups. Results. Pre-eclampsia prevalence was 7.1% among primigravidas and 4.6% among multigravidas. The cutoff concentration was 2.0 MoM in both groups. For primigravidas and multigravidas, respectively, the area below the curve was 0.96 and 0.95; sensitivity was 88.5% and 100% ; specificity was 92.0% and 85.6% ; positive predictive value was 0.46 and 0.25; and negative predictive value was 0.99 and 1.0. With a cutoff concentration of 2.0 MoM of β - hCG, the positive likelihood ratio was 11.1 in primigravidas and 6.9 in multigravidas. Conclusion. This study shows that measuring levels of β - hCG during the second trimester of pregnancy is useful in clinical practice to identify pregnant women who will develop pre-eclampsia.
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