Magnesium based implants for functional bone tissue regeneration–A review

作     者：Gavish Uppal Amit Thakur Amit Chauhan Saroj Bala Gavish Uppal;Amit Thakur;Amit Chauhan;Saroj Bala

作者机构：University Institute of Engineering and TechnologyPanjab Universitysector-14ChandigarhIndia Sri Guru Gobind Singh CollegePanjab Universitysector-26ChandigarhIndia 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2022年第10卷第2期

页      面：384-419页

核心收录：

学科分类：0806[工学-冶金工程] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This research did not receive any specific grant from funding agencies in the public  commercial  or not-for-profit sectors 

主　　题：Magnesium Biodegradable orthopedic implant Porous structure Osteo-conductive Antibacterial 

摘      要：Magnesium(Mg)has emerged as one of the third-generation biomaterials for regeneration and support of functional bone *** is a better choice over permanent implants such as titanium,stainless steel,cobalt-chrome as magnesium is biodegradable and does not require a second surgery for its removal after bone tissue *** also reduces the risk of stress shielding as its elastic modulus is closer to human bone in comparison to permanent implants and other biodegradable metallic implants based on Iron and *** importantly,Mg is osteoconductive thus stimulates new bone formation and possess anti-bacterial properties hence reducing the risk of failure due to *** its advantages,a major concern with pure Mg is its rapid bio-corrosion in presence of body fluids due to which the mechanical integrity of the implant deteriorates before healing of the tissue is *** properties of Mg-based implants can be enhanced by mechanical processing,alloying,and topology *** reduce the corrosion/degradation rate,Mg has been alloyed with metals,reinforced with ceramics,and surface coatings have been applied so that the degradation rate of Mg-based implant matches with that of healing rate of bone *** present review discusses the effect of alloying elements and reinforcing ceramics on microstructure,mechanical,and corrosion properties of Mg-based orthopedic *** addition,the biocompatibility of Mg-based alloys,composites,and coatings applied on Mg implants has been ***,different methods of fabricating porous implants have been highlighted as making the implant porous facilitates the growth of new bone tissue through the pores.