THERMAL-SENSITIVE BETA-CYCLODEXTRIN-CONTAINING POLY(NISOPROPYLACRYLAMIDE)HYDROGELS CROSSLINKED BY Si—O—Si BONDS—SYNTHESIS,CHARACTERIZATION AND PROLONGING IN VITRO RELEASE OF 5-FLUOROURACIL

作     者：Jian-tao Zhang Shi-wen Huang Ya-nan Xue Ji Liu and Ren-xi Zhuo Key Laboratory of Biomedical Polymers,Ministry of Education Department of Chemistry,Wuhan University,Wuhan 430072,China 

作者机构：Key Laboratory of Biomedical Polymers Ministry of Education Department of Chemistry Wuhan University Wuhan 430072 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2005年第23卷第5期

页      面：513-519页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 0817[工学-化学工程与技术] 08[工学] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 

基　　金：This work was financially supported by the National Key Basic Research Program of China(973 Program)(No.G1999064703) 

主　　题：Hydrogel Thermal-sensitive Poly(N-isopropylacrylamide) Beta-Cyclodextrin Fast responsive. 

摘      要：A series of novel p（N-isopropylacrylamide） （PNIPAM） hydrogels were synthesized by radical copolymerization of N-isopropylacrylamide （NIPAM） and 3-methacryloxypropyltrimethoxysilane （MPTMS）. The copolymers were then crosslinked through hydrolysis of the siloxane in acetic acid/water mixed solvent. Beta-cyclodextrin （Beta-CD） was introduced into the polymeric networks by condensation of 3-glycidoxypropyltrimethoxysilane derived beta-cyclodextrin （KH560-beta-CD） with MPTMS under acidic condition. These gels were heterogeneous, porous and exhibited fast deswelling kinetics when the temperature was elevated to above lower critical solution temperature （LCST）. The swelling ratios of the gels containing beta-CD at room temperature were higher than that of the normal PNIPAM hydrogel, which was caused by the lower crosslinking density in beta-CD contained gels. In comparison to that of the normal PNIPAM gel, the amount of loaded-drug in the hydrogel containing beta-CD was higher, and the release time of 5-fluorouracil （5-Fu） was prolonged, which was attributed to the formation of inclusion compounds between 5-Fu and beta-CD in gel network.