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thermal-sensitive BETA-CYCLODEXTRIN-CONTAINING POLY(NISOPROPYLACRYLAMIDE)HYDROGELS CROSSLINKED BY Si—O—Si BONDS—SYNTHESIS,CHARACTERIZATION AND PROLONGING IN VITRO RELEASE OF 5-FLUOROURACIL

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Chinese Journal of Polymer Science 2005年第5期23卷 513-519页

作者： Jian-tao Zhang Shi-wen Huang Ya-nan Xue Ji Liu and Ren-xi Zhuo Key Laboratory of Biomedical Polymers,Ministry of Education Department of Chemistry,Wuhan University,Wuhan 430072,China Key Laboratory of Biomedical Polymers Ministry of Education Department of Chemistry Wuhan University Wuhan 430072 China

A series of novel p（N-isopropylacrylamide）（PNIPAM） hydrogels were synthesized by radical copolymerization of N-isopropylacrylamide （NIPAM） and 3-methacryloxypropyltrimethoxysilane （MPTMS）. The copolymers were then crosslinked through hydrolysis of the siloxane in acetic acid/water mixed solvent. Beta-cyclodextrin （Beta-CD） was introduced into the polymeric networks by condensation of 3-glycidoxypropyltrimethoxysilane derived beta-cyclodextrin （KH560-beta-CD） with MPTMS under acidic condition. These gels were heterogeneous, porous and exhibited fast deswelling kinetics when the temperature was elevated to above lower critical solution temperature （LCST）. The swelling ratios of the gels containing beta-CD at room temperature were higher than that of the normal PNIPAM hydrogel, which was caused by the lower crosslinking density in beta-CD contained gels. In comparison to that of the normal PNIPAM gel, the amount of loaded-drug in the hydrogel containing beta-CD was higher, and the release time of 5-fluorouracil （5-Fu） was prolonged, which was attributed to the formation of inclusion compounds between 5-Fu and beta-CD in gel network.

关键词： Hydrogel thermal-sensitive Poly(N-isopropylacrylamide) Beta-Cyclodextrin Fast responsive.

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Tribological behavior of thermal- and pH-sensitive microgels under steel/CoCrMo alloy contacts

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Friction 2023年第4期11卷 602-616页

作者： Kequn SUN Yuanhua HU Yinghui DONG Lulu YAO Ruhong SONG Yufu XU Institute of Tribology School of Mechanical EngineeringHefei University of TechnologyHefei 230009China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China

The tribological behavior of 316L stainless steel/CoCrMo alloy contacts under aqueous lubrication was investigated in this *** types of microgels including poly(N-isopropylacrylamide)(PNIPAM),polyacrylic acid(PAA),and poly(N-isopropylacrylamide-co-acrylic acid)(PNIPAM-co-PAA)were prepared and used as lubricant additives in aqueous *** tests were conducted using a ball-on-disk reciprocating tribometer,over a range of temperatures,pH,and concentrations of the *** PNIPAM-co-PAA microgels were proven to have excellent anti-friction and anti-wear properties,depending on the temperature and pH values of the *** maximum friction coefficient coincided with the lower critical solution temperature of the PNIPAM-co-PAA microgels at 32°*** the same time,the friction coefficient increased with the increase in pH value of the lubricant solution with the PNIPAM-co-PAA *** unique thermal-and pH-sensitive properties of the PNIPAM-co-PAA microgels provided a new strategy for controlling the friction and wear of steel/CoCrMo alloy contacts under aqueous lubrication.

关键词： poly(N-isopropylacrylamide-co-acrylic acid)(PNIPAM-co-PAA) microgel aqueous lubrication thermal-sensitive pH-sensitive

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