Biological Evaluation of α-TCP/TTCP Composite Bone Cement

作     者：戴红莲 DAI Hong lian 1) YAN Yu hua 1) WANG You fa 1) ZHOU Xue dong 1) YU Guo rong 2) 1) Wuhan University of Technology 2) Central South Hospital Attached to Wuhan University Biomedical Materials and Enginee

作者机构：WuhanUniversityofTechnology 

出 版 物：《Journal of Wuhan University of Technology(Materials Science)》 (武汉理工大学学报（材料科学英文版）)

年 卷 期：2002年第17卷第3期

页      面：35-38页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：FundedbytheNaturalScienceFoundationofHubeiProvince (2 0 0 0J0 34) 

主　　题：α-TCP/TTCP bone cement biocompatibility bioactivity 

摘      要：tricalcium phosphate(α TCP)/tetracalcium phosphate(TTCP) composite bone cement had good hydration *** our system,α TCP/TTCP powder mixture was mixed with water at a powder/liquid (P/L) ratio of 1.50g·mL -1 .The setting time could be adjusted,the maximum compressive strength was 45.36MPa,and the hydration product was hydroxyapatite (HAP).In vitro biological simulated experiments indicate that α TCP/TTCP bone cement has α certain *** hardened product is mainly HAP after soaking in simulated body fluid (SBF) for 10 *** results of in vitro test and animal experiments and SEM analyses show that no local or general toxicity response,no muscle stimulation,no haemolysis,no cruor,no inflammatory reaction and no exclusion response are caused by α TCP/TTCP cement, which can be contributed to bone tissue spreading and impinging.α TCP/TTCP cement hydrated and hardened continually in *** materials fused with host bone together with implanting time ***,it is believed that α TCP/TTCP composite bone cement has a high biocompatibility and bioactivity,a certain biodegradation and good osteogenesis as well.