Cumulative Risk Assessment of Exposure to Heavy Metals through Aquatic Products in China

作     者：WANG Hui MAO Wei Feng JIANG Ding Guo LIU Si Jie ZHANG Lei WANG Hui;MAO Wei Feng;JIANG Ding Guo;LIU Si Jie;ZHANG Lei

作者机构：NHC Key Laboratory of Food Safety Risk AssessmentChinese Academy of Medical Science Research UnitChina National Center for Food Safety Risk AssessmentBeijing 100022China Department of Physical and Chemical TestJilin Provincial Center for Disease Control and PreventionChangchun 130062JilinChina 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2021年第34卷第8期

页      面：606-615页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100403[医学-营养与食品卫生学] 10[医学] 

基　　金：the Min istry of Scie nee and Tech no logy of the People's Republic of China[No.2018YFC1603104] Chinese Academy of Medical Science Research Unit Program[NO.2019-12M-5-024]. 

主　　题：Arsenic Lead Cadmium Mercury Aquatic products Heavy metals 

摘      要：Objective This study aimed to assess the risk of cumulative exposure to Pb,Cd,Hg,and iAs through aquatic products consumed by Chinese people.Methods Heavy metal concentration data were obtained from the national food contamination monitoring program during 2013–2017.Consumption data were derived from the China National Food Consumption Survey in 2014 and the relative potency factor(RPF)method was used to estimate cumulative exposure for neurotoxicity and nephrotoxicity.Results The results demonstrated that the cumulative exposure based on neurotoxicity was below the lower confidence limit on benchmark doses of lead(BMDL01)for nephrotoxicity and the cumulative exposures were all lower than the provisional tolerable monthly intake(PTMI)of Cd.However,the margin of exposure values(MOEs)of the cumulative exposures for neurotoxicity in the 2–6 year-old group was close to 1 and the cumulative exposure level for nephrotoxicity accounted for 90.21%of the PTMI.Conclusion The cumulative exposures of the 2–6 year-old group to the four heavy metals did not reach(but came close to)the corresponding safety threshold for both neurotoxicity and nephrotoxicity.Given that there are still other food sources of these four heavy metals,it is necessary to more closely study their cumulative health effects.