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Effects of co-exposure to Lead and manganese on learning and memory deficits

Journal of Environmental Sciences 2022年第11期34卷 65-76页

作者： Ruili Guan Tao Wang Xiaoru Dong Kejun Du Juan Li Fang Zhao Jie Xu Bin Li Gang Zheng Xuefeng Shen Baohua Cao Jing Wang Michael Aschner Mingchao Liu Rui Chen Key Laboratory of Environmental Medicine Engineering Ministry of EducationSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Occupational&Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public HealthFourth Military Medical UniversityXi’an 710032China Department of Physiology National Key Discipline of Cell BiologyFourth Military Medical UniversityXi’an 710032China School of Nursing Fourth Military Medical UniversityXi’an 710032China Department of Molecular Pharmacology Albert Einstein College of MedicineBronxNYUSA IM Sechenov First Moscow State Medical University MoscowRussia

Lead(Pb) and manganese(Mn) are common neurotoxins. However, individuals are subject to co-exposures in real life, and it is therefore important to study these metals in combination. Weaning Sprague-Dawley rats were given ad libitum access to drinking water solutions containing Pb(100 mg/L), Mn(2.5 mg/m L) or a mixture, and each treatment had its own minocycline(50 mg/(kg·day)) supplement group. The results showed a significant difference in spatial memory and induction levels of hippocampal long-term potentiation(LTP) in all exposure groups when compared with controls. The combined-exposure group exhibited the most pronounced effect when compared with each of the single-metal exposure groups.Microglia displayed activation at day 3 after exposure alone or in combination, while astrocytes showed activation at day 5, accompanied by decreased expression levels of GLAST,GLT-1, and GS. Furthermore, the levels of glutamate in the synaptic cleft increased significantly. When microglial activation was inhibited by minocycline, the activation of astrocytes and the expression of GLAST, GLT-1, and GS were both reversed. In addition, upon minocycline treatment, hippocampal LTP impairment and cognitive injury were significantly alleviated in each of the exposure groups. These results suggest that combined exposure to Pb and Mn can cause greater effects on cognition and synaptic plasticity when compared to single-metal exposure groups. The reason may involve abnormal activation of microglia Leading to excessive regulation of astrocytes, resulting in glutamate reuptake dysfunction in astrocytes and Leading to perturbed cognition and synaptic plasticity.

关键词： Lead Manganese Microglia Astrocyte Learning and memory

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Environmental exposure to cadmium but not Lead is associated with decreased semen quality parameters:quality regionalism of sperm properties

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Asian Journal of Andrology 2022年第1期24卷 26-31页

作者： Katarzyna Olszak-Wasik Andrzej Tukiendorf Aleksandra Kasperczyk Artur Wdowiak Stanislaw Horak Department of Gynecology Obstetrics and Oncological Gynecology in BytomMedical University of SilesiaSchool of Medicine and Division of Dentistry in ZabrzeBatorego 15Bytom 41-902Poland Department of Public Health Wroclaw Medical UniversityBartla 5Wroclaw 51-618Poland Department of Biochemistry Medical University of SilesiaSchool of Medicine and Division of Dentistry in ZabrzeJordana 19Zabrze 41-808Poland Faculty of Health Sciences Diagnostic Techniques UnitMedical University of LublinStaszica 4/6Lublin 20-081Poland

Environmental factors may negatively contribute to a progressive worsening of semen quality,and differences in semen quality may result from different environmental exposures(regional differences)or lifestyle differences.Heavy metals are factors with a confirmed negative influence on male fertility.Among them,Lead and cadmium are commonly found in human surroundings.Thus,we analyzed semen parameters(according to the World Health Organization 2010 recommendations)and semen Lead and cadmium concentrations in 188 men from two different regions in Poland,a typical agricultural area and an industrial area,in couples that had been diagnosed with infertility.The assays were performed using flameless electrothermal atomic absorption spectrometry.In the statistical analysis,regional comparisons and then taxonomic comparisons based on three parameters(age,semen concentration,and sperm morphology)were applied.We showed that more cadmium than Lead accumulated in semen,a higher cadmium concentration was observed in semen obtained from men from the agricultural region,and better semen quality and lower cadmium concentrations were found in the semen of men from the industrial,more polluted region.We thus showed an existing regionalism in the sperm quality properties.However,semen parameters such as morphology and progressive and nonprogressive motility followed the same trends,regardless of the patient’s age,region,or class.We could conclude that the environment has a minor impact on sperm morphology and progressive and nonprogressive motility and that other existing factors could have an indirect influence on semen quality.

关键词： cadmium environment Lead semen quality taxonomic analysis

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A novel surface-oxidized rigid carbon foam with hierarchical macro-nanoporous structure for efficient removal of malachite green and Lead ion

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Journal of Materials Science & Technology 2022年第8期103卷 15-28页

作者： Qiyun Zhang Renquan Wu Yunhong Zhou Qilang Lin Changqing Fang College of Advanced Manufacturing Fuzhou UniversityJinjiang 362251China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350116China Faculty of Printing Packing Engineering and Digital Media TechnologyXi’an University of TechnologyXi’an 710048China

This study developed a method to fabricate a surface-oxidized rigid carbon foam(ORCF)with hierarchical macro-nanoporous structure via KOH activation of the carbon foam with two kinds of macropores followed by HNO_(3) hydrothermal oxidation.The structures of the prepared ORCF were characterized using scanning electron microscopy,transmission electron microscopy,X-ray diffraction,Fourier transform infrared(FTIR)spectra,X-ray photoelectron spectroscopy,and N_(2) adsorption-desorption analyzer.Results demonstrate that the ORCF possesses a fluffy and porous structure with rich oxygen-containing groups.There are numerous through-holes on its pore surfaces connected with two-level macropores forming hierarchical macroporous channels.Meanwhile,the ORCF remains a good bulk structure with a compression strength of 0.74 MPa at a bulk density of 0.09 g cm^(−3).Batch adsorption experiments for malachite green(MG)and Pb^(2+) were studied through the single variable method to investigate the effects of different initial conditions on its adsorption process.The ORCF has maximum adsorption capacities for MG and Pb^(2+) of 587.68 mg g^(−1) and 157.80 mg g^(−1) with high partition coefficients of 17.41 mg g^(−1)μM^(−1) and 14.86 mg g^(−1)μM^(−1),respectively.The experimental data are suitable for Langmuir isotherm and Pseudo-secondorder kinetic models,which correspond to monolayer chemisorption.Thermodynamic analysis indicates that the adsorption process is spontaneous and endothermic.Moreover,the removal percentages of MG and Pb^(2+)by the ORCF could remain above 90%after five cycles,implying that the ORCF is an efficient adsorbent with good adsorption ability and cycling stability.

关键词： HNO3 oxidation Carbon foam Malachite green Lead Adsorption

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A highly efficient humidity sensor based on Lead(Ⅱ) coordination polymer via in-situ decarboxylation and hydrolysis synthesis

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Rare Metals 2022年第5期41卷 1652-1660页

作者： Hao Dong Le-Xi Zhang Heng Xu Yan-Yan Yin Yi-Fei Liu Li-Jian Bie School of Materials Science and Engineering Tianjin Key Laboratory for Photoelectric Materials and DevicesKey Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)National Demonstration Center for Experimental Function Materials EducationTianjin University of TechnologyTianjin 300384China Department of Environmental Science and Engineering Nankai University Binhai CollegeTianjin 300270China

Function-oriented design of coordination polymers is emerging as an attracting topic to explore their practical applications, e.g., gas/humidity sensing. However,the successful synthesis of new coordination polymers showing splendid sensing property is an urgent need in fields of materials and sensors, yet still at the initial stage.In this contribution, a new one-dimensional(1D) coordination polymer with formula of [Pb(TAA)(BA)(H_(2)O)]_(n)(namedasPbL,HTAA = 3-thiopheneaceticacid,HBA = benzoic acid) has been successfully synthesized by a hydrothermal method, which involves in-situ synthesis of both decarboxylation and hydrolysis. As an impedimetric humidity sensing material, this coordination polymer exhibits excellent humidity sensing performance including high response, fast response, small hysteresis, and good repeatability. In the total relative humidity range(11%–97%) at room temperature, it is worth noting that the sensitivity of the humidity sensor is as high as 1.18×10^(4),the response time is only 2 s, and the max humidity hysteresis is as small as 1.8%. At last, we discussed the sensing mechanism using the alternating current(AC) impedance technique at various relative humidity.

关键词： Lead Coordination polymer In-situ synthesis Humidity sensor

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Colonization of Penicillium oxalicum SL2 in Pb-contaminated paddy soil and its immobilization effect on soil Pb

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Journal of Environmental Sciences 2022年第10期34卷 53-62页

作者： Yu Gao Xiaohan Jiang Hanxin Wu Jianhao Tong Xinyue Ren Jiayu Ren Qianhua Wu Jien Ye Chunhui Li Jiyan Shi Department of Environmental Engineering College of Environmental and Resource ScienceZhejiang UniversityHangzhou 310058China MOE Key Laboratory of Environmental Remediation and Ecological Health College of Environmental and Resource ScienceZhejiang UniversityHangzhou 310058China

Penicillium oxalicum SL2(SL2) is a previously screened Pb-tolerant fungus that can promote crops growth. The relationship between SL2 colonization and Pb immobilization was studied to provide a theoretical basis for microbial remediation of Pb-contaminated paddy soil.In this study, green fluorescent protein(GFP) labeled SL2 was inoculated into different Pbcontaminated paddy soils(S1-S6). The Pb extracted from the soil by HNO, EDTA and CaClwere used to characterize the available Pb. The results showed that the colonization of SL2was divided into lag phase(0-7 days), growth phase(7-30 days), and mortality phase(30-90days). SL2 colonized well in sandy soils rich in clay and total phosphorus with initial p H of 4.5-7.0. In addition, SL2 increased soil p H and decreased soil Eh, which was beneficial to immobilize Pb. In different soils, the highest percentages of CaCl-Pb, EDTA-Pb, and HNO3-Pb immobilized by SL2 were 34.34%-40.53%, 17.05%-20.11%, and 7.39%-15.62%, respectively.Pearson correlation analysis showed that the percentages of CaCl-Pb and EDTA-Pb immobilized by SL2 were significantly positively correlated with the number of SL2 during the growth phase. SL2 mainly immobilized Pb in the growth phase and a higher peak number of SL2 was beneficial to the immobilization of Pb.

关键词： Penicillium oxalicum SL2 Colonization Lead Availability Green fluorescent protein

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A novel electrolytic-manganese-residues-and-serpentine-based composite(S-EMR) for enhanced Cd(Ⅱ) and Pb(Ⅱ) adsorption in aquatic environment

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Rare Metals 2023年第1期42卷 346-358页

作者： Meng-Yu Ma Xuan Ke Yan-Chang Liu Zhi-Hao Ha Ting Wang Jia Li Fan Zhang Tian C.Zhang College of Resources and Environmental Science South-Central Minzu UniversityWuhan430074China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan430074China College of Engineering University of Nebraska-LincolnOmahaNE68182USA

Electrolytic manganese residue(EMR) is the waste slag generated from the electrolysis manganese industry.As a promising exploitable adsorbent,EMR has become a hot research topic.However,EMR’s low adsorption capacity has limited its applications as an efficient adsorbent.In this study,the EMR was mixed with serpentine and calcined(at 800℃ for 2 h) to prepare a composite adsorbent(S-EMR) with its specific surface area of 11.998 m^(2)·g^(-1)(increased compared to the original EMR) and improved adsorption capacities for Cd^(2+)(98.05 mg·g^(-1)) and Pb^(2+)(565.81 mg·g^(-1)).Kinetic studies have shown that the pseudo-first-order kinetics(PSO)model could best describe the adsorption kinetics of S-EMR for Cd^(2+)/Pb^(2+),implying that the chemisorption process is the rate-limiting step.The effects of different interfering ions on S-EMR’ s adsorption for Cd^(2+)/Pb^(2+)may be due to the difference in their electronegativity.Results of response surface methodology tests showed that pH had the highest influence on adsorption,and the removal efficiency of S-EMR reached 99.92% for Cd(Ⅱ) and 94.00%for Pb(Ⅱ).X-ray photoelectron spectroscopy(XPS) analyses revealed that chemical precipitation was the predominant mechanism for Cd^(2+)/Pb^(2+)removal,and the adsorption mechanisms were associated with ion exchange and electrostatic attraction.The results showed that S-EMR could be used as an effective adsorbent for the removal of Cd(Ⅱ)/Pb(Ⅱ) from water bodies,rendering dual benefits of pollution control and resource recovery.

关键词： Cadmium Lead Electrolytic manganese residue Serpentine Heavy metals

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D-serine reduces memory impairment and neuronal damage induced by chronic Lead exposure

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Neural Regeneration Research 2021年第5期16卷 836-841页

作者： Jian-Zhu Bo Ling Xue Shuang Li Jing-Wen Yin Zheng-Yao Li Xi Wang Jun-Feng Wang Yan-Shu Zhang College of Public Health North China University of Science and TechnologyTangshanHebei ProvinceChina Laboratory Animal Center North China University of Science and TechnologyTangshanHebei ProvinceChina

Although exogenous D-serine has been applied as a neural regulatory intervention in many studies,the role played by D-serine in hippocampal injuries caused by Lead exposure remains poorly understood.Rat models of chronic Lead exposure were established through the administration of 0.05%Lead acetate for 8 weeks.Simultaneously,rats were administered 30 or 60 mg/kg D-serine,intraperitoneally,twice a day.Our results showed that D-serine treatment shortened the escape latency from the Morris water maze,increased the number of times that mice crossed the original platform location,and alleviated the pathological damage experienced by hippocampal neurons in response to Lead exposure.Although D-serine administration did not increase the expression levels of the N-methyl-D-aspartate receptor subtype 2B(NR2B)in the hippocampi of Lead-exposed rats,60 mg/kg D-serine treatment restored the expression levels of NR2A,which are reduced by Lead exposure.These findings suggested that D-serine can alleviate learning and memory impairments induced by Lead exposure and that the underlying mechanism is associated with the increased expression of NR2A in the hippocampus.This study was approved by the Animal Ethics Committee of North China University of Science and Technology,China(approval No.LX2018155)on December 21,2018.

关键词： D-serine hippocampus Lead neurological function N-methyl-D-aspartate poisoning protection repair

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Perovskite solar cell towards lower toxicity: a theoretical study of physical Lead reduction strategy

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Science Bulletin 2019年第17期64卷 1255-1261页

作者： Yifan Zheng Rui Su Zhaojian Xu Deying Luo Hua Dong Bo Jiao Zhaoxin Wu Qihuang Gong Rui Zhu State Key Laboratory for Mesoscopic Physics School of Physics Nano-optoelectronics Frontier Center of Ministry of Education (NFC-MOE)& Collaborative Innovation Center of Quantum Matter Peking University Beijing 100871 China Collaborative Innovation Center of Extreme Optics Shanxi University Taiyuan 030006 China Key Laboratory of Photonics Technology for Information Key Laboratory for Physical Electronics and Devices of the Ministry o f Education Department o f Electronic Science and Technology School of Electronic and Information Engineering Xi'an Jiaotong University Xi'an 710049 China

The huge performance enhancements of the organometal halide perovskite solar cells(OHPSCs) have appealed enormous attention within recent ten years. Although the rapid growth of the device power conversion efficiency(PCE) has attained over 25%, the contamination of health-hazardous components still holds back its sustainable applications. To reduce the Lead usage, many groups have tried chemical Lead reduction solutions: substituting the Lead by other group 14 metal elements to realize the low-Lead OHPSCs. Unfortunately, neither the PCE nor the stability, low-Lead OHPSCs all lag far behind the state-ofthe-art conventional Lead-based OHPSCs. In this work, we present a physical Lead reduction(PLR) concept by reducing the perovskite film thickness to restrict the perovskite hazard risk with minor scarification in device performances. Through the simulation of transfer matrix model, we theoretically demonstrated that by introducing the optical space layer, the device PCE could maintain 96% of the original maximum value while attenuating the perovskite film thickness to one-third. This means that the usage of Lead can be reduced by $70% with PLR concept, which could have broad appeal as a new Lead reduction strategy towards high performance OHPSCs.

关键词： Perovskite solar cell Physical Lead reduction Low toxicity Optical space layer Transfer matrix model

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Bacterial resistance to Lead: Chemical basis and environmental relevance

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Journal of Environmental Sciences 2019年第11期31卷 46-55页

作者： Qiying Nong Ke Yuan Zhuang Li Ping Chen Yongshun Huang Ligang Hu Jie Jiang Tiangang Luan Baowei Chen Southern Marine Science and Engineering Guangdong Laboratory School of Marine Sciences Sun Yat-Sen University Zhuhai 519082 China School of Life Sciences Sun Yat-Sen University Guangzhou 510275 China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences P.O.Box 2871 Beijing 100085 Guangdong Provincial Hospital for Occupational Diseases Prevention and Treatment Guangzhou 510300 China School o/Enuironmental Science and Engineering Sim Yat-sen University Guangzhou 510275 PR China Shenzhen Center for Disease Control and Prevention Shenzhen 518055 China

Natural bacterial isolates from heavily contaminated sites may evolve diverse tolerance strategies,including biosorption,efflux mechanism,and intracellular precipitation under the continually increased stress of toxic Lead (Pb) from anthropogenic activities.These strategies utilize a large variety of functional groups in biological macromolecules (e.g.,exopolysaccharides (EPSs) and metalloproteins) and inorganic ligands,including carboxyl,phosphate and amide groups,for capturing Pb.The amount and type of binding sites carried by biologically originated materials essentially determines their performance and potential for Pb removal and remediation.Many factors,e.g.,metal ion radius,electronegativity,the shape of the cell surface sheath,temperature and pH,are thought to exert significant influences on the abovementioned interactions with Pb.Conclusively,understanding the chemical basis of Pb-binding in these bacteria can allow for the development of effective microbial Pb remediation technologies and further elucidation of Pb cycling in the environment.

关键词： Lead Resistance mechanisms Bacteria Biosorption Immobilization Remediation

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Structural simplification: an efficient strategy in Lead optimization

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Acta Pharmaceutica Sinica B 2019年第5期9卷 880-901页

作者： Shengzheng Wang Guoqiang Dong Chunquan Sheng Department of Medicinal Chemistry School of PharmacySecond Military Medical UniversityShanghai200433China Department of Medicinal Chemistry and Pharmaceutical Analysis School of PharmacyFourth Military MedicalUniversityXi’an710032China

The trend toward designing large hydrophobic molecules for Lead optimization is often associated with poor drug-likeness and high attrition rates in drug discovery and development. Structural simplification is a powerful strategy for improving the efficiency and success rate of drug design by avoiding 'molecular obesity'. The structural simplification of large or complex Lead compounds by truncating unnecessary groups can not only improve their synthetic accessibility but also improve their pharmacokinetic profiles, reduce side effects and so on. This review will summarize the application of structural simplification in Lead optimization. Numerous case studies, particularly those involving successful examples Leading to marketed drugs or drug-like candidates, will be introduced and analyzed to illustrate the design strategies and guidelines for structural simplification.

关键词： Structural simplification Lead optimization Drug discovery Drug design Reducing rings number Reducing chiral centers Structure-based simplification Pharmacophore-based simplification

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