Connecting inorganic mercury and lead measurements in blood to dietary sources of exposure that may impact child development

作     者：Renee J Dufault Mesay M Wolle H M Skip Kingston Steven G Gilbert Joseph A Murray 

作者机构：Food Ingredient and Health Research InstituteNaalehuHI 96772United States College of Graduate Health StudiesA.T.Still UniversityKirksvilleMO 63501United States Department of Chemistry and BiochemistryDuquesne UniversityPittsburghPA 15282United States Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Division of Gastroenterology and HepatologyMayo ClinicRochesterMN 55905United States 

出 版 物：《World Journal of Methodology》 (世界方法学杂志)

年 卷 期：2021年第11卷第4期

页      面：144-159页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Autism Paraoxonase 1 Selenium Inorganic mercury Lead Attention deficit hyperactivity disorder 

摘      要：Pre-natal and post-natal chemical exposures and co-exposures from a variety of sources including contaminated air,water,soil,and food are common and associated with poorer birth and child health *** diet is a contributing factor in the development of child behavioral *** behavior and learning can be adversely impacted when gene expression is altered by dietary transcription factors such as zinc insufficiency or deficiency or by exposure to toxic substances permitted in our food supply such as mercury,lead,or organophosphate pesticide *** with autism spectrum disorder and attention deficit hyperactivity disorders exhibit decreased or impaired PON1 gene activity which is needed by the body to metabolize and excrete neurotoxic organophosphate *** this current review we present an updated macroepigenetic model that explains how dietary inorganic mercury and lead exposures from unhealthy diet may lead to elevated blood mercury and/or lead levels and the development of symptoms associated with the autism and attention deficithyperactivity ***1 gene activity may be suppressed by inadequate dietary calcium,selenium,and fatty acid intake or exposures to lead or *** model may assist clinicians in diagnosing and treating the symptoms associated with these childhood neurodevelopmental *** for future research are provided based on the updated model and review of recently published literature.