CD8+CD28-T cells:not only age-related cells but a subset of regulatory T cells

作     者：Xiaoyong Chen Qiuli Liu Andy Peng Xiang 

作者机构：Center for Stem Cell Biology and Tissue EngineeringKey Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-Sen UniversityGuangzhouChina The Biotherapy CenterThe Third Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2018年第15卷第8期

页      面：734-736页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grant from the National Key Research and Development Program of China,Stem Cell and Translational Research(2017YFA0103403,2017YFA0105504) the National Natural Science Foundation of China(81425016,81600102,81601381,31771616,81730005) the Natural Science Foundation of Guangdong Province(S2013030013305,2016A030310131) the Key Scientific and Technological Projects of Guangdong Province(2014B020226002,2015B020228001,2015B020229001,2016A020214003,2016B030229002) Key Scientific and Technological Program of Guangzhou City(201508020262,201704020223) Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(GDUPS,2013) 

主　　题：CD28 expression. stimulator 

摘      要：CD28 serves as a co-stimulator for T-cell activation and survival,and is expressed on all naive T cells in newborns.1 However,as T cells experience antigenmediated activation and differentiation,they gradually lose CD28 expression.2 The age-related increase of CD28−T cells in human peripheral blood means that immune function declines in the elderly.1 Among the populations of CD28-T cells,CD8+CD28-T cells show the greatest age-related increase.1 These cells,which were first described in aged humans,exhibit weak immuneresponsiveness and shortened telomeres and are often considered to exhibit ageassociated replicative senescence.