Eradication of Helicobacter pylori increases childhood growth and serum acylated ghrelin levels

作     者：Yao-Jong Yang Bor-Shyang Sheu Hsiao-Bai Yang Cheng-Chan Lu Ching-Chun Chuang 

作者机构：Departments of Pediatrics and Institute ofClinical Medicine Medical College National Cheng Kung Uni-versity Tainan 70428 Taiwan China Departments of Internal Medicine and In-stitute of Clinical Medicine Medical College National ChengKung University Tainan 70428 Taiwan China Ton-Yen General Hospital Hsinchu County70428 Taiwan China Department of PathologyMedical College National Cheng Kung University Tainan70428 Taiwan China Institute of Clinical Medicine MedicalCollege National Cheng Kung University Tainan 70428 Tai-wan China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第21期

页      面：2674-2681页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：Supported by National Cheng Kung University Hospital, Tainan,China, No. NCKUH96-030 DOH99-TD-C-111-003 from Department of Health,Taiwan, China, No. DOH99-TD-C-111-003 

主　　题：ghrelin 幽门螺杆菌 儿童 血清 根除 酰化 生长 幽门螺旋杆菌 

摘      要：AIM: To determine whether Helicobacter pylori (H. pylori)infected children have reduced body weight (BW) and height (BH) growth, and if H. pylori eradication may restore growth while improving serum acylated ghrelin. METHODS: This longitudinal cohort study with oneyear follow-up enrolled 1222 children aged 4 to 12 years old into an observation cohort (18 with and 318 without H. pylori ) and intervention cohort (75 with and 811 without). The 7-d triple therapy was used for eradication in the intervention cohort. The net increases of BW and BH as well serum acylated ghrelin after oneyear follow-up were compared between successful eradicated H. pylori-infected children and controls. RESULTS: In the observation cohort, the H. pylori - infected children had lower z score of BW (-1.11 ± 0.47 vs 0.35 ± 0.69, P = 0.01) and body mass index (BMI) (0.06 ± 0.45 vs 0.44 ± 0.73, P = 0.02) at enrollment and lower net BW gain after one-year follow-up (3.3 ± 2.1 kg vs 4.5 ± 2.4 kg, P = 0.04) than the non-infected controls. In the intervention cohort, the H. pylori - infected children had lower z score of BMI (0.25 ± 1.09 vs 0.68 ± 0.87, P = 0.009) and serum acylated ghrelin levels (41.8 ± 35.6 pg/mL vs 83.6 ± 24.2 pg/mL, P 0.001) than the non-infected controls. In addition to restoring decreased serum ghrelin levels (87.7 ± 38.0 pg/mL vs 44.2 ± 39.0 pg/mL, P 0.001), the H. pylori - infected children with successful eradication had higher net gains (P 0.05) and increase of z scores (P 0.05) of both BW and BH as compared with non-infected controls after one-year follow-up. CONCLUSION:H. pylori-infected children are associated with low serum acylated ghrelin and growth retardation. Successful eradication of H. pylori restores ghrelin levels and increases growth in children.