A smart dual-drug nanosystem based on coassembly of plant and food-derived natural products for synergistic HCC immunotherapy

作     者：Bingchen Zhang Jiali Jiang Pengyu Wu Junjie Zou Jingqing Le Juanfang Lin Chao Li Bangyue Luo Yongjie Zhang Rui Huang Jingwei Shao Bingchen Zhang;Jiali Jiang;Pengyu Wu;Junjie Zou;Jingqing Le;Juanfang Lin;Chao Li;Bangyue Luo;Yongjie Zhang;Rui Huang;Jingwei Shao

作者机构：Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and ChemotherapyCollege of ChemistryFuzhou UniversityFuzhou 350116China Institute of OceanographyMinjiang UniversityFuzhou 350108China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第1期

页      面：246-257页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 100602[医学-中西医结合临床] 

基　　金：supported by the National Natural Science Foundation of China(81972832) Natural Science Foundation of Fujian Province(2018J01895,China) College Students’Innovation and Entrepreneurship Training Program of Fujian Province(S202010386051,China) 

主　　题：Natural product Ursolic acid EGCG Aptamer Co-assembly Nanodrug HCC Synergistic treatment Immunotherapy 

摘      要：Nanotechnology has emerged as an ideal approach for achieving the efficient chemo agent delivery.However,the potential toxicity and unclear internal metabolism of most nano-carriers was still a major obstacle for the clinical application.Herein,a novelcore-shellco-assembly carrier-free nanosystem was constructed based on natural sources of ursolic acid(UA)and polyphenol(EGCG)with the EpCAM-aptamer modification for hepatocellular carcinoma(HCC)synergistic treatment.As the nature products derived from food-plant,UA and EGCG had good anticancer activities and low toxicity.With the simple andgreenmethod,the nanodrugs had the advantages of good stability,p H-responsive and strong penetration of tumor tissues,which was expected to increase tumor cellular uptake,long circulation and effectively avoid the potential defects of traditional carriers.The nanocomplex exhibited the low cytotoxicity in the normal cells in vitro,good biosafety of organic tissues and efficient tumor accumulation in vivo.Importantly,UA combined with EGCG showed the immunotherapy by activating the innate immunity and acquired immunity resulting in significant synergistic therapeutic effect.The research could provide new ideas for the research and development of self-assembly delivery system in the future,and offer effective intervention strategies for clinical HCC treatment.