Recent advances in hydrogel-based anti-infective coatings

作     者：Mengjing Fu Yijing Liang Xue Lv Chengnan Li Yi Yan Yang Peiyan Yuan Xin Ding Mengjing Fu;Yijing Liang;Xue Lv;Chengnan Li;Yi Yan Yang;Peiyan Yuan;Xin Ding

作者机构：School of Pharmaceutical Sciences(Shenzhen)Sun Yat-sen UniversityShenzhen518107China Institute of Bioengineering and Nanotechnology31 Biopolis WaySingapore138669Singapore 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2021年第85卷第26期

页      面：169-183页

核心收录：

学科分类：0817[工学-化学工程与技术] 0806[工学-冶金工程] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0802[工学-机械工程] 0801[工学-力学（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：financially supported by the National Natural Science Foundation of China(Nos.81803481,81830103 and 31900982) the Shenzhen Science and Technology Program(Nos.KQTD20190929173853397 and JCYJ20200109142401698) the Fundamental Research Funds for the Central Universities of China(Nos.20ykpy123 and 19ykpy142) the Institute of Bioengineering and Nanotechnology(Biomedical Research Council,Agency for Science,Technology and Research,Singapore)(Nos.SC 19/08-101002) 

主　　题：Biofilm Hydrogel Coating Antifouling Bactericidal 

摘      要：Bacterial infections associated with biomedical devices and implants have posed a great challenge to global healthcare *** infections are mainly caused by bacterial biofilm formed on the surface of biomaterials,protecting the encapsulated bacteria from conventional antibiotic treatment and attack of the immune *** the bacterial biofilm is difficult to eradicate,bactericidal and antifouling coatings have emerged as promising strategies to prevent biofilm fo rmation and subsequent *** with three-dimensional crosslinked hydrophilic networks,tunable mechanical property and large drugloading capacity are desirable coating materials,which can kill bacteria and/or prevent bacterial adhesion on the surface,inhibiting biofilm ***,we review recent developments of hydrogels as anti-infective ***,we highlight two chemical approaches(graft-from and graft-to),which have been used to immobilize hydrogels on surfaces,and present advances in the development of bactericidal(contact-killing and antimicrobial-releasing),antifouling(hydrophilic polymer network)and bifunctional hydrogel coatings with both bactericidal and antifouling *** addition,the challe nges of hydrogel coatings for clinical applications are discussed,and future research directions of anti-infective hydrogel coatings are proposed.