Living Materials for Life Healthcare
作者机构：Zhongshan-Xuhui HospitalThe Shanghai Key Laboratory of Medical EpigeneticsInstitutes of Biomedical SciencesFudan UniversityShanghai 200032China Department of Rheumatology and ImmunologyInstitute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China State Key Laboratory of BioelectronicsSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China
出 版 物：《Accounts of Materials Research》 (材料研究述评（英文）)
年 卷 期：2021年第2卷第1期
页 面：59-70页
学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
基 金：This work was supported by the National Key Research and Development Program of China(2020YFA0908200) the National Natural Science Foundation of China(grant nos.22002018,52073060,and 61927805) the Natural Science Foundation of Jiangsu(grant no.BE2018707) the Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning(grant no.SSH1340011) the Launching Research Fund from Fudan University(grant no.JIH1340038) Zhongshan-Xuhui Hospital(grant no.KJK04202000012)
主 题：composites precise Living
摘 要：CONSPECTUS:Living material is a type of composite material with living elements integrated into nonliving *** combines the advantages of both living cells and nonliving substances and takes advantage of advanced fabrication *** materials is an emerging new paradigm at the frontiers of materials *** addresses an intriguing question of how to let materials show life-like capabilities and function in an integrative and programmable *** all of the capability and application aspects of living materials,the one related to human health is the most intriguing since it implies that that materials could be made by life and used for ***,living materials exploit the merits of cells in that they can respond to environmental variables,synthesize functional molecules,and span multiple length *** the same time,the abundant coordination between live and nonliving elements opens infinite possibilities for diverse structural and functional *** resultant biohybrid materials are thus endowed with novel functions that recapitulate or even surpass their natural candidates and ultimately shed new light on biodiagnostics and biotherapeutics to address human health *** this Account,we present a concise summary and analysis of living materials and bring it into the context of addressing life healthcare *** start with the fabrication of living materials,including the engineering of living elements and the manufacturing of biohybrid composites through advanced technologies,particularly micropatterning,microfluidics,and threedimensional(3D)*** then shift to the properties and capacities of living materials,such as autonomous motion,sensing and actuation,and highly sensitive *** the basis of these,we show,by representative examples,the healthcare-oriented applications of living materials in both diagnostic and biotherapeutic aspects,including biohybrid sensors and actuators,cell-powered robotics,organ
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