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SYNTHESIS AND BIOACTIVITIES OF NEW LHRH ANTAGONISTS CONTAINING NOVEL UNNATURAL AMINO ACIDS AT POSITION FIVE

SYNTHESIS AND BIOACTIVITIES OF NEW LHRH ANTAGONISTS CONTAINING NOVEL UNNATURAL AMINO ACIDS AT POSITION FIVE

作     者:刘克良 何炳林 萧绍博 夏启明 方溪 王忠义 

作者机构:Institute of Pharmacology and ToxicologyPO Box130 Institute of Polymer Chemistry Nankai University Tianjin Municipal Research Institute for Family Planning Tianjin Medical College 

出 版 物:《Science China Chemistry》 (中国科学(化学英文版))

年 卷 期:1991年第34卷第2期

页      面:201-208页

核心收录:

学科分类:07[理学] 0703[理学-化学] 

基  金:This work was supported in part by grants from United Nations Fund for Population Activities (UNFPA) and State Family Planning Commission of China 

主  题:new antagonists of LHRH antiovulatoty activity solid-phase synthesis of peptides 

摘      要: Synthesis and bioactivities of new antagonists of luteinizing hormone releasing hormone(LHRH) with novel unnatural amino acids at position five are reported, Most of them showedsome antiovulatory activity at 0. 5μg/rat and two of them inhibited ovulation completely at1μg/rat using saline as vehicle.

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