SYNTHESIS AND BIOACTIVITIES OF NEW LHRH ANTAGONISTS CONTAINING NOVEL UNNATURAL AMINO ACIDS AT POSITION FIVE

作     者：刘克良 何炳林 萧绍博 夏启明 方溪 王忠义 

作者机构：Institute of Pharmacology and ToxicologyPO Box130 Institute of Polymer Chemistry Nankai University Tianjin Municipal Research Institute for Family Planning Tianjin Medical College 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：1991年第34卷第2期

页      面：201-208页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：This work was supported in part by grants from United Nations Fund for Population Activities (UNFPA) and State Family Planning Commission of China 

主　　题：new antagonists of LHRH antiovulatoty activity solid-phase synthesis of peptides 

摘      要： Synthesis and bioactivities of new antagonists of luteinizing hormone releasing hormone(LHRH) with novel unnatural amino acids at position five are reported, Most of them showedsome antiovulatory activity at 0. 5μg/rat and two of them inhibited ovulation completely at1μg/rat using saline as vehicle.