SYNTHESIS AND BIOACTIVITIES OF NEW LHRH ANTAGONISTS CONTAINING NOVEL UNNATURAL AMINO ACIDS AT POSITION FIVE
SYNTHESIS AND BIOACTIVITIES OF NEW LHRH ANTAGONISTS CONTAINING NOVEL UNNATURAL AMINO ACIDS AT POSITION FIVE作者机构:Institute of Pharmacology and ToxicologyPO Box130 Institute of Polymer Chemistry Nankai University Tianjin Municipal Research Institute for Family Planning Tianjin Medical College
出 版 物:《Science China Chemistry》 (中国科学(化学英文版))
年 卷 期:1991年第34卷第2期
页 面:201-208页
核心收录:
主 题:new antagonists of LHRH antiovulatoty activity solid-phase synthesis of peptides
摘 要: Synthesis and bioactivities of new antagonists of luteinizing hormone releasing hormone(LHRH) with novel unnatural amino acids at position five are reported, Most of them showedsome antiovulatory activity at 0. 5μg/rat and two of them inhibited ovulation completely at1μg/rat using saline as vehicle.