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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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Urban Resilience in Post-disaster Reconstruction: Towards a Resilient Development in Sichuan,China

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International Journal of disaster Risk Science 2012年第1期3卷 45-55页

作者： Yan Guo School of Doctorate Studies University IUAV of Venice(Istituto Universitàdi Architettura di Venezia)30125 VeniceItaly

This article discusses the post-disaster urban resilience design framework in the case of post-disaster urban reconstruction in Sichuan after the Great Sichuan Earthquake(also known as the Wenchuan Earthquake) in May 2008 in China. The focus is on three main aspects of post-disaster urban reconstruction: sociospatial coherence,temporal continuity,and multistakeholder integration and communication. Critical interpretation of the government-guided reconstruction reveals that reconstruction was limited to the generic production and implementation of top-down planning. From the perspective of urban resilience,and through an alternative design scenario developed in this research,this article highlights an urban resilience design framework based on postdisaster development in the Sichuan city of Dujiangyan. By identifying the deficiencies of the governmental reconstruction where in many aspects resilience has not been considered,and by proposing the alternative where resilience has been considered to develop a better living,this research seeks to integrate urban resilience as a key aspect in the Sichuan reconstruction and as essential for developing the postdisaster city towards a more coherent,sustainable,and integral urban future.

关键词： China. disaster urban

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Lighting the shades of hidden pain:a role for spinal cord neurons and microglia in vestibulodynia

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Neural Regeneration Research 2025年第10期20卷 2898-2900页

作者： Rosmara Infantino Francesca Gargano Serena Boccella Carmela Belardo Andrea Maria Morace Francesca Guida Sabatino Maione Livio Luongo Department of Experimental Medicine Division of PharmacologyUniversitàdegli Studi della Campania“L.Vanvitelli”Italy universitàCampus Bio-medico di Roma RomeItaly

Vulvodynia,a chronic pain disorder affecting the vulvar region,represents a significant challenge in both diagnosis and treatment within the field of women’s *** condition is characterized by chronic pain that significantly affects the quality of life of afflicted *** present perspective paper examines the role of spinal sensitization and microglial activation in vulvodynia.

关键词： pain diagnosis activation

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How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia La Barbera Paraskevi Krashia Annalisa Nobili Department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly Department of Experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly Department of Science and Technology for Sustainable Development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

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Extreme Cities and Bad Places

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International Journal of disaster Risk Science 2012年第1期3卷 3-10页

作者： Paola Viganò Department of Urbanism University IUAV of Venice(Istituto Universitario di Architettura di Venezia)30125 VeniceItaly

This article considers places where climate change-induced hazards will be particularly important,focusing on two examples,the lagoon location of Venice and the Garonne riverbank location of Bordeaux. The Venice lagoon territory is close to the coast and has a dispersed form of urban development. Our project experiments resulted in the formulation of a series of adaptation strategies to increased disaster risks,including returning current agricultural land and residential areas to their original state as wetlands and marshes before their reclamation during the early decades of the twentieth century. The scenarios introduce space as a relevant variable into the debate about the impact of climate change and adaptation. This article also deals with the recovery of “bad places,” such as the urban blight on the Garonne riverbanks of Bordeaux,and their relationship with sustainability and disaster risks. Increasingly,the emphasis on minimizing energy consumption and promoting recycling forces cities to reuse places of elevated risk. Only very recently in modern urban planning are polluted and risky areas frequently selected for new development projects to reclaim the vast areas of existing brownfields in the name of sustainability. Integrating disaster risk reduction into a new economic and social context has thus become an extremely important part of contemporary urban design and planning for these reclaimed(bad) areas. The research concludes that urban and territorial design should and can integrate the inevitability of risk. This is necessary for developing approaches and strategies that offer some rethinking about “wicked” problems,long-term time horizons,radical imagination,dynamic representations,and minute territorial readings in contemporary urban planning.

关键词： disaster urban contemporary

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Extreme Cities and Isotropic Territories: Scenarios and Projects Arising from the Environmental Emergency of the Central Veneto Città diffusa

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International Journal of disaster Risk Science 2012年第1期3卷 11-22页

作者： Lorenzo Fabian Department of Urbanism University IUAV of Venice(Istituto Universitario di Architettura di Venezia)30125 VeniceItaly

In Italy extreme cities and territories occur at the extremities of lagoons,coastlines,and river deltas,in hydraulically reclaimed and hydrogeologically instable areas,and those where the water supply network has been placed underground,channeled into piping,or removed altogether. These areas are now increasingly subject to natural calamities and extreme weather conditions,and the consequences of climate change and the fragility of the more and more impermeable and urbanized land surface are clearly evident. Isotropic territories are characterized by weak hierarchization of infrastructure and settlement. The metropolitan area of Venice,aptly described as a diffuse city(città diffusa),and other diffusely organized territories characterized by settlement dispersion are good examples of this phenomenon. This article reviews recent research at the university iuav of Venice in a study on climate change and water forms,a project in which the profound relations between water networks,the geological nature of the terrain,forms of urbanization,and energy saving are tested out. The study of the territories of the Venetian metropolitan area provides a series of initial working hypotheses as to how the ongoing environmental emergency can become an opportunity for a development project of the city and the territory,capable of structuring its various parts differently.

关键词： extreme consequences underground

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Before the War,War,After the War: Urban Imageries for Urban Resilience

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International Journal of disaster Risk Science 2012年第1期3卷 23-37页

作者： Armina Pilav School of Doctorate Studies University IUAV of Venice(Istituto Universitario di Architettura di Venezia)30125 VeniceItaly

This article discusses urban conditions in cities that in their recent history experienced war. It puts the social component of the city into relationship with the destroyed and dangerous urban environment. In the period between 1992 and 1996 in Sarajevo and in other Bosnian cities,survival became the most important activity for citizens. In the period directly preceding the war,urban conditions—mobility,infrastructure,and services—started to malfunction. As a result,ordinary city life became an object of new urban imageries influenced by new urban conditions and rules of behavior. The first bombing of the city on 6 April 1992 was a sign that the war had started. It brought with it war urban conditions: lack of public transport,electricity,water,and food. The inability of the city and the people living in it to function normally demanded new patterns of urban resilience,which were partly a product of the city’s prewar conditions. Using Sarajevo as a case study,this article examines whether the city had predisaster coping strategies and,if so,the extent to which these plans were used during the war. Finally,the article observes how citizens,with their own imageries about cities,can participate in the creation of patterns of urban resilience and future predisaster strategies.

关键词： disaster destroyed urban

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Behaviour of a Moment Resisting Composite Steel and Concrete Joint Under Alternate Loading

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施工技术 2011年第6期40卷 93-101,110页

作者： Alberto Zanchettin Bruno Briseghella Tobia Zordan università iuav di venezia College of Civil Engineering Fuzhou University College of Civil Engineering Tongji University

The authors show the results of a study conducted on a joint connecting a concrete column to a composite steel concrete floor,subjected to tension on the beams as a result of the decomposition of sagging bending *** beam to column connection is achieved by means of headed studs welded to the beam and embedded in the concrete *** different configurations have been tested at failure and the results are compared to formulae proposed in *** degrees of ductility,reliability and strength have been obtained varying geometry and reinforcement ratio on the joints tested.

关键词： composite steel concrete joint laboratory test analysis alternate loading

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GIS tools for preliminary debris-flow assessment at regional scale

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Journal of Mountain Science 2017年第12期14卷 2498-2510页

作者： cavalli marco crema stefano trevisani sebastiano marchi lorenzo consiglio nazionale delle ricerche istituto di ricerca per la protezione idrogeologicaCorso Stati Uniti 435127 PadovaItaly universitàdi padova dipartimento territorio e sistemi agro-forestaliVia dell’Universita 1635020 Legnaro(PD)Italy universitàiuav di venezia dipartimento di architettura costruzione conservazioneDorsoduro 220630123 VeneziaItaly

The assessment of the areas endangered by debris flows is a major issue in the context of mountain watershed management. Depending on the scale of analysis, different methods are required for the assessment of the areas exposed to debris *** 2-D numerical models are advised for detailed mapping of inundation areas on individual alluvial fans, preliminary recognition of hazard areas at the regional scale can be adequately performed by less data-demanding methods, which enable priority ranking of channels and alluvial fans at risk by debris flows. This contribution focuses on a simple and fast procedure that has been implemented for regionalscale identification of debris-flow prone channels and prioritization of the related alluvial fans. The methodology is based on the analysis of morphometric parameters derived from digital Elevation Models(DEMs). Potential initiation sites of debris flows are identified as the DEM cells that exceed a threshold of slope-dependent contributing area. Channel reaches corresponding to debris flows propagation, deceleration and stopping conditions are derived from thresholds of local slope. An analysis of longitudinal profiles is used for the computation of the runout distance of debris flows. Information on erosion-resistant bedrock channels and sediment availability surveyed in the field are taken into account in the applications. A set of software tools was developed and made available(https://***/Hydrogeomorphology Tools) to facilitate the application of the procedure. This approach, which has been extensively validated by means of field checks, has been extensively applied in the eastern Italian Alps. This contribution discusses potential and limitations of the method in the frame of the management of small mountain watersheds.

关键词： Debris flow Geographic information system digital elevation models Runout Alluvial fan Watershed management Geomorphometry

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Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state

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Neural Regeneration Research 2025年第7期20卷 2008-2010页

作者： Elena Ambrosini Angela Lanciotti Maria Stefania Brignone Department of Neuroscience Istituto Superiore di SanitàRomeItaly

Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult *** maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.

关键词： alterations modulator maintain

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