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New Era: Endoscopic treatment options in obesity–a paradigm shift

World Journal of Gastroenterology 2019年第32期25卷 4567-4579页

作者： Jason Glass Ahson Chaudhry Muhammad S Zeeshan Zeeshan Ramzan Department of Digestive and Liver Diseases University of Texas Southwestern Medical CenterDallasTX 75390United States Division of Gastroenterology and Hepatology Department of MedicineDallas VA Medical CenterVA North Texas Health Care SystemDallasTX 75216United States School of Medicine Temple University HospitalPhiladelphiaPA 19140United States

The prevalence of obesity continues to rise,and along with it comes a multitude of health-related *** healthcare community has consistently struggled with providing treatment options to obese patients,in part due to the reluctance of patients in pursuing the more effective(yet invasive)surgical approaches such as sleeve gastrectomy and Rou-en-Y gastric *** the other hand,the less invasive approach such as lifestyle/behavioral interventions and pharmacotherapy(Orlistat,Phenteramine,Phentermine/Topiramate,Locaserin,Naltrexon/Buproprion,and Liraglutide)have very limited efficacy,especially in the morbidly obese *** our best efforts,the epidemic of obesity continues to rise and pose enormous costs on our healthcare system and *** endoscopy is an evolving field generated to combat this epidemic through minimally invasive *** procedures can be performed in an ambulatory setting,are potentially reversible,repeatable,and pose less complications than their invasive surgical *** modalities are designed to alter gut metabolism by means of space occupation,malabsorption,or *** this review we will discuss different bariatric endoscopic options(such as intragastric balloons,endoscopic sleeve gastroplasty,endoscopic aspiration therapies and gastrointestinal bypass sleeves),their advantages and disadvantages,and suggest a new paradigm where providers may start incorporating this modality in their treatment approach for obese patients.

关键词： Bariatric endoscopy Bariatrics Obesity Intragastric balloon Bariatric medicine AspireAssist Endoscopic sleeve gastroplasty

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自锁板(钉)系统在下颌骨手术中的应用

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中华口腔医学杂志 2007年第6期42卷 381-384页

作者： Edward Ellis Ⅲ 何冬梅（译）张益（校） Division of Oral and Maxiuofacial Surgery University of Texas Southwestern Medical Center Parkland Memorial Hospital. 不详

不同类型的接骨板为下颌骨骨折和截骨提供了稳定的固定。传统接骨板（钉）系统的缺点是接骨板必须与骨面完全贴合才能防止在螺钉拧紧时，骨段凶适应接骨板形态而发生位置改变和咬合关系变化。自锁板（钉）系统在下颌骨骨折和骨缺损的治... 详细信息

不同类型的接骨板为下颌骨骨折和截骨提供了稳定的固定。传统接骨板（钉）系统的缺点是接骨板必须与骨面完全贴合才能防止在螺钉拧紧时，骨段凶适应接骨板形态而发生位置改变和咬合关系变化。自锁板（钉）系统在下颌骨骨折和骨缺损的治疗中所显现的优势远远超过其他板（钉）系统。通过将螺钉锁结徉板上而获得稳定性，自锁板（钉）系统的独特优势就足接骨板不必与骨而紧衔接触.

关键词：下颌骨骨折系统自锁手术中接骨板咬合关系位置改变同类型

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Coordinated control of oligodendrocyte development by extrinsic and intrinsic signaling cues

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Neuroscience Bulletin 2013年第2期29卷 129-143页

作者： Li He Q.Richard Lu Department of Pediatrics and Obstetrics/Gynaecology Institute of Stem Cell and Developmental BiologyWest ChinaSecond HospitalSichuan University Department of Developmental Biology and Kent Waldrep Foundation center for Basic Neuroscience Research on NerveGrowth and Regeneration University of Texas Southwestern Medical Center

Oligodendrocytes, the myelin-forming cells for axon ensheathment in the central nervous system, are critical for maximizing and maintaining the conduction velocity of nerve impulses and proper brain function. Demyeli- nation caused by injury or disease together with failure of myelin regeneration disrupts the rapid propagation of action potentials along nerve fibers, and is associated with acquired and inherited disorders, including dev- astating multiple sclerosis and leukodystrophies. The molecular mechanisms of oligodendrocyte myelination and remyelination remain poorly understood. Recently, a series of signaling pathways including Shh, Notch, BMP and Wnt signaling and their intracellular effectors such as Olig1/2, Hesl/5, Smads and TCFs, have been shown to play important roles in regulating oligodendrocyte development and myelination. In this review, we summarize our recent understanding of how these signaling pathways modulate the progression of oligoden- drocyte specification and differentiation in a spatiotemporally-specific manner. A better understanding of the complex but coordinated function of extracellular signals and intracellular determinants during oligodendrocyte development will help to devise effective strategies to promote myelin repair for patients with demyelinating diseases.

关键词： oligodendrocyte specification differentiation myelination Shh, BMP, Notch and Wnt signaling transcription factors chromatin remodeling factors HDAC miRNAs

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Cardiac-specific knockout of ET_(A)receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction

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分子细胞生物学报:英文版 2012年第2期4卷 97-107页

作者： Yingmei Zhang Linlin Li Yinan Hua Jennifer M.Nunn Feng Dong Masashi Yanagisawa Jun Ren Department of Cardiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China center for Cardiovascular Research and Alternative Medicine University of WyomingLaramieWY 82071USA Department of Pharmacology Xinjiang Medical UniversityUrumqiXinjiang 830011P.R.China Howard Hughes medical Institute University of Texas Southwestern Medical CenterDallasTX 75390USA

Cold exposure is associated with oxidative stress and cardiac *** endothelin(ET)system,which plays a key role in myocardial homeostasis,may participate in cold exposure-induced cardiovascular *** study was designed to examine the role of ET-1 in cold stress-induced cardiac geometric and contractile ***-type(WT)and ETA receptor knockout(ETAKO)mice were assigned to normal or cold exposure(48C)environment for 2 and 5 weeks prior to evaluation of cardiac geometry,contractile,and intracellular Ca21 *** of the temperature sensor transient receptor potential vanilloid(TRPV1),mitochondrial proteins for biogenesis and oxidative phosphorylation,including UCP2,HSP90,and PGC1a were *** stress triggered cardiac hypertrophy,depressed myocardial contractile capacity,including fractional shortening,peak shortening,and maximal velocity of shortening/relengthening,reduced intracellular Ca21 release,prolonged intracellular Ca21 decay and relengthening duration,generation of ROS and superoxide,as well as apoptosis,the effects of which were blunted by *** blotting revealed downregulated TRPV1 and PGC1a as well as upregulated UCP2 and activation of GSK3b,GATA4,and CREB in cold-stressed WT mouse hearts,which were obliterated by *** of HSP90,an essential regulator for thermotolerance,were *** TRPV1 agonist SA13353 attenuated whereas TRPV1 antagonist capsazepine mimicked cold stress-or ET-1-induced cardiac *** GSK3b inhibitor SB216763 ablated cold stress-induced cardiac contractile(but not remodeling)changes and ET-1-induced TRPV1 *** data suggest that ETAKO protects against cold exposure-induced cardiac remodeling and dysfunction mediated through TRPV1 and mitochondrial function.

关键词： low ambient temperature myocardial function ET_(A)receptor TRPV1 mitochondria

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Additional risk factors associated with thrombosis and pregnancy morbidity in a unique cohort of antiphospholipid antibody-positive patients

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Chinese medical Journal 2022年第6期135卷 658-664页

作者： Chun Li Yu Zuo Song Zhang Una E.Makris David R.Karp Zhanguo Li Department of Rheumatology and Immunology Peking University People's HospitalBeijing 100044China Division of Rheumatology Department of Internal MedicineUniversity of MichiganAnn ArborMichiganUSA Division of Biostatistics Department of Clinical SciencesUT Southwestern Medical CenterDallasTXUSA medical Service VA North Texas Health Care SystemDallasTXUSA Division of Rheumatic Disease Department of Internal MedicineThe University of Texas Southwestern Medical CenterDallasTXUSA

Background:Antiphospholipid syndrome(APS)is an autoimmune prothrombotic condition with significant *** objective of this study was to identify additional clinical and epidemiological risks of arterial thrombosis,venous thrombosis,and pregnancy morbidities in a large cohort of persistent antiphospholipid antibodies(aPLs)-positive ***:This was a cross-sectional cohort study of 453 consecutive patients with a documented positive aPL who attended Peking university People's *** 453 patients screened,297 patients had persistent positive *** compared asymptomatic aPL carriers with thrombotic and obstetric APS *** the univariate analysis and multivariable logistic regression were used to evaluate the association between different risk factors and APS clinical *** levels of circulating markers of neutrophil extracellular traps(NETs)(cell-free DNA and citrullinated histone H3[Cit-H3])were assessed and compared among aPL-positive carriers with or without autoimmune disease and APS ***:Additional risk factors associated with arterial thrombosis among aPL-positive carriers included:smoking(odds ratio[OR]=6.137,95%confidence interval[CI]=2.408-15.637,P=0.0001),hypertension(OR=2.368,95%CI=1.249-4.491,P=0.008),and the presence of underlying autoimmune disease(OR=4.401,95%CI=2.387-8.113,P<0.001).Additional risks associated with venous thrombosis among aPL carriers included:smoking(OR=4.594,95%CI=1.681-12.553,P=0.029)and the presence of underlying autoimmune disease(OR=6.330,95%CI=3.355-11.940,P<0.001).The presence of underlying autoimmune disease(OR=3.301,95%CI=1.407-7.744,P=0.006)is the additional risk,which demonstrated a significant association with APS pregnancy *** circulating levels of cell-free DNA and Cit-H3 were observed among APS patients and aPL patients with autoimmune diseases compared with those aPL carriers without underlying autoimmune ***,control neutrophils that

关键词： Antiphospholipid antibodies Antiphospholipid syndrome Arterial thrombosis Pregnancy risk Venous thrombosis

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Inhibitory leukocyte immunoglobulin-like receptors in cancer development

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Science China(Life Sciences) 2015年第12期58卷 1216-1225页

作者： ZHANG FeiFei ZHENG JunKe KANG XunLei DENG Mi LU ZhiGang KIM Jaehyup ZHANG ChengCheng Hongqiao International Institute of Medicine Shanghai Tongren Hospital Faculty of Basic Medicine Shanghai Jiao Tong University School of Medicine Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education Shanghai Jiao Tong University School of Medicine Departments of Physiology and Developmental Biology University of Texas Southwestern Medical Center

Inhibitory leukocyte immunoglobulin-like receptors(LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs(ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6(PTPN6, SHP-1), protein tyrosine phosphatase, non-receptor type 6(PTPN6, SHP-2), or Src homology 2 domain containing inositol phosphatase(SHIP) to negatively regulate immune cell activation. These receptors are known to play important regulatory roles in immune and neuronal functions. Recent studies demonstrated that several of these receptors are expressed by cancer cells. Importantly, they may directly regulate development, drug resistance, and relapse of cancer, and the activity of cancer stem cells. Although counterintuitive, these findings are consistent with the generally immune-suppressive and thus tumor-promoting roles of the inhibitory receptors in the immune system. This review focuses on the ligands, expression pattern, signaling, and function of LILRB family in the context of cancer development. Because inhibition of the signaling of certain LILRBs directly blocks cancer growth and stimulates immunity that may suppress tumorigenesis, but does not disturb normal development, LILRB signaling pathways may represent ideal targets for treating hematological malignancies and perhaps other tumors.

关键词： immunoreceptor tyrosine-based inhibitory motifs immunoreceptor tyrosine-based activation motif leukocyte immunoglobulin-like receptor subfamily B immunoglobulin-like transcript leukocyte immunoglobulin-like receptor phosphatase ITIM ITAM LILRB CD85 ILT LIR SHP-1 SHP-2 SHIP MHC HLA signal transduction leukemia cancer

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The cartilage matrisome in adolescent idiopathic scoliosis

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Bone Research 2020年第1期8卷 1-13页

作者： Carol AWise Diane Sepich Aki Ushiki Anas MKhanshour Yared HKidane Nadja Makki Christina AGurnett Ryan SGray Jonathan JRios Nadav Ahituv Lila Solnica-Krezel center for Pediatric Bone Biology and Translational Research Texas Scottish Rite Hospital for Children2222 Welborn St.DallasTX 75219USA McDermott center for Human Growth and Development University of Texas Southwestern Medical CenterDallasTX 75235USA Departments of Pediatrics University of Texas Southwestern Medical CenterDallasTX 75235USA Orthopaedic Surgery University of Texas Southwestern Medical CenterDallasTX 75235USA Department of Developmental Biology Washington University School of MedicineSt.LouisMO 63110USA Department of Bioengineering and Therapeutic Sciences University of California San FranciscoSan FranciscoCA 94158USA Institute for Human Genetics University of California San FranciscoSan FranciscoCA 94158USA Department of Anatomy and Cell Biology University of FloridaCollege of MedicineGainesvilleFL 32610USA Departments of Neurology Washington University School of MedicineSt LouisMO 63110USA Pediatrics Washington University School of MedicineSt LouisMO 63110USA Orthopaedic Surgery Washington University School of MedicineSt LouisMO 63110USA Department of Pediatrics Dell Pediatric Research InstituteUniversity of Texas at Austin Dell Medical SchoolAustinTX 78723USA

The human spinal column is a dynamic,segmented,bony,and cartilaginous structure that protects the neurologic system and simultaneously provides balance and *** with developmental disorders that affect the patterning or shape of the spine can be at risk of neurologic and other physiologic *** most common developmental disorder of the spine is scoliosis,a lateral deformity in the shape of the spinal *** may be part of the clinical spectrum that is observed in many developmental disorders,but typically presents as an isolated symptom in otherwise healthy adolescent *** idiopathic scoliosis(AIS)has defied understanding in part due to its genetic *** have come from recent genome-wide association studies(GWAS)and next generation sequencing(NGS)of human AIS cohorts,as well as investigations of animal *** studies have identified genetic associations with determinants of cartilage biogenesis and development of the intervertebral disc(IVD).Current evidence suggests that a fraction of AIS cases may arise from variation in factors involved in the structural integrity and homeostasis of the cartilaginous extracellular matrix(ECM).Here,we review the development of the spine and spinal cartilages,the composition of the cartilage ECM,the so-called"matrisome"and its functions,and the players involved in the genetic architecture of *** also propose a molecular model by which the cartilage matrisome of the IVD contributes to AIS susceptibility.

关键词： cartilage adolescent scoliosis

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,phospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,phospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

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The Underlying Mechanism of Reprogramming Process by SOX4/11 and NGN2: Reprogramming Glioblastoma Cells into Neuron Cells

The Underlying Mechanism of Reprogramming Process by SOX4/11...

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2018年浙江省神经外科学学术年会

作者： Jianjing Yang Chun-li Zhang Qichuan Zhuge Department of Neurosurgery The First Affiliated Hospital of Wenzhou Medical University Department of Molecular Biology University of Texas Southwestern Medical Center

Objective Glioblastoma is the most common malignant tumor in the central nervous system. We previously demonstrated that pro-neural transcription factors mouse sox11 (msox11) could catalyze human NGN2 (hNGN2) highly efficient reprogramming glioblastoma cell into neuron cell. However, the underlying mechanism is largely remains unknown and the clinical application is limited.

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Autoimmune gastritis:Pathologist's viewpoint

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World Journal of Gastroenterology 2015年第42期21卷 12179-12189页

作者： Irene Coati Matteo Fassan Fabio Farinati David Y Graham Robert M Genta Massimo Rugge Department of Medicine (DIMED) Surgical Pathology Unit University of Padua Department of Surgery Oncology and Gastroenterology Gastroenterology Unit University of Padua Department of Medicine Veterans Administration Hospital Baylor College of Medicine Houston Miraca Life Sciences Research Institute Departments of Pathology and Medicine VA North Texas Health Care System and University of Texas Southwestern Medical Center Dallas

Western countries are seeing a constant decline in the incidence of Helicobacter pylori-associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune gastritis. This latter gastropathy is due to autoimmune aggression targeting parietal cells through a complex interaction of auto-antibodies against the parietal cell proton pump and intrinsic factor, and sensitized T cells. Given the specific target of this aggression, autoimmune gastritis is typically restricted to the gastric corpus-fundus mucosa. In advanced cases, the oxyntic epithelia are replaced by atrophic(and metaplastic) mucosa, creating the phenotypic background in which both gastric neuroendocrine tumors and(intestinal-type) adenocarcinomas may develop. Despite improvements in our understanding of the phenotypic changes or cascades occurring in this autoimmune setting, no reliable biomarkers are available for identifying patients at higher risk of developing a gastric neoplasm. The standardization of autoimmune gastritis histology reports and classifications in diagnostic practice is a prerequisite for implementing definitive secondary prevention strategies based on multidisciplinary diagnostic approaches integratingendoscopy, serology, histology and molecular profiling.

关键词： Autoimmune gastritis Metaplasia Carcinoids Operati

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