Autoimmune gastritis:Pathologist's viewpoint
Autoimmune gastritis:Pathologist's viewpoint作者机构：Department of Medicine (DIMED) Surgical Pathology Unit University of Padua Department of Surgery Oncology and Gastroenterology Gastroenterology Unit University of Padua Department of MedicineVeterans Administration Hospital Baylor College of Medicine Houston Miraca Life Sciences Research Institute Departments of Pathology and Medicine VA North Texas Health Care System and University of Texas Southwestern Medical Center Dallas
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2015年第21卷第42期
页 面：12179-12189页
核心收录：
基 金：Supported by A grant from the Italian Association for Cancer Research(partly,AIRC Regional grant 2008 No.6421) published under the auspices of the Healthy Stomach Initiative(HIS)
主 题：Autoimmune gastritis Metaplasia Carcinoids Operati
摘 要：Western countries are seeing a constant decline in the incidence of Helicobacter pylori-associated gastritis, coupled with a rising epidemiological and clinical impact of autoimmune gastritis. This latter gastropathy is due to autoimmune aggression targeting parietal cells through a complex interaction of auto-antibodies against the parietal cell proton pump and intrinsic factor, and sensitized T cells. Given the specific target of this aggression, autoimmune gastritis is typically restricted to the gastric corpus-fundus mucosa. In advanced cases, the oxyntic epithelia are replaced by atrophic(and metaplastic) mucosa, creating the phenotypic background in which both gastric neuroendocrine tumors and(intestinal-type) adenocarcinomas may develop. Despite improvements in our understanding of the phenotypic changes or cascades occurring in this autoimmune setting, no reliable biomarkers are available for identifying patients at higher risk of developing a gastric neoplasm. The standardization of autoimmune gastritis histology reports and classifications in diagnostic practice is a prerequisite for implementing definitive secondary prevention strategies based on multidisciplinary diagnostic approaches integratingendoscopy, serology, histology and molecular profiling.
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