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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Signal Transduction and Targeted Therapy 2024年第3期9卷 945-997页

作者： Jian Sheng Loh Wen Qi Mak Li Kar Stella Tan Chu Xin Ng Hong Hao Chan Shiau Hueh Yeow Jhi Biau Foo Yong Sze Ong Chee Wun How Kooi Yeong Khaw School of Pharmacy Monash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia School of Pharmacy Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia Digital Health&Medical Advancements Taylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia School of Biosciences Faculty of Health&Medical SciencesTaylor’s University1Jalan TaylorsSubang Jaya 47500 SelangorMalaysia UCL School of Pharmacy University College London29-39 Brunswick SquareLondon WC1N 1AXUK

The human gastrointestinal tract is populated with a diverse microbial *** vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology,including health maintenance,development,aging,and *** advent of new sequencing technologies and culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations to shed light on microbiome–host *** has unveiled the bidirectional communication between the gut microbiome and the central nervous system,referred to as the“microbiota–gut–brain axis”.The microbiota–gut–brain axis represents an important regulator of glial functions,making it an actionable target to ameliorate the development and progression of neurodegenerative *** this review,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative *** the gut microbiome provides essential cues to microglia,astrocytes,and oligodendrocytes,we examine the communications between gut microbiota and these glial cells during healthy states and neurodegenerative ***,we discuss the mechanisms of the microbiota–gut–brain axis in neurodegenerative diseases using a metabolite-centric approach,while also examining the role of gut microbiota-related neurotransmitters and gut ***,we examine the potential of targeting the intestinal barrier,blood–brain barrier,meninges,and peripheral immune system to counteract glial dysfunction in ***,we conclude by assessing the pre-clinical and clinical evidence of probiotics,prebiotics,and fecal microbiota transplantation in neurodegenerative diseases.A thorough comprehension of the microbiota–gut–brain axis will foster the development of effective therapeutic interventions for the management of neurodegenerative diseases.

关键词： degenerative therapeutic diseases

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MXenes and heterostructures-based electrocatalysts for hydrogen evolution reaction:Recent developments and future outlook

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Journal of Energy Chemistry 2024年第5期92卷 176-206页

作者： Abdul Hanan Hafiz Taimoor Ahmed Awan Faiza Bibi Raja Rafidah Raja Sulaiman Wai Yin Wong Rashmi Walvekar Seema Singh Mohammad Khalid Sunway Centre for Electrochemical Energy and Sustainable Technology(SCEEST) School of Engineering and TechnologySunway UniversityNo.5 Jalan UniversitiBandar Sunway47500 Petaling JayaSelangorMalaysia Fuel Cell Institute Universiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia Faculty of Innovation and Technology School of EngineeringChemical Engineering ProgrammeNo.1 Jalan Taylor’sTaylor’s University Malaysia47500 Subang JayaSelangorMalaysia Chitkara Centre for Research and Development Chitkara UniversityHimachal Pradesh 174103India School of Applied and Life Sciences Uttaranchal UniversityDehradunUttarakhand 248007India Manipal Institute of Technology Manipal Academy of Higher EducationManipal 576104KarnatakaIndia Centre of Research Impact and Outcome Chitkara UniversityPunjab 140401India

The increasing focus on electrocatalysis for sustainable hydrogen(H_(2))production has prompted significant interest in MXenes,a class of two-dimensional(2D)materials comprising metal carbides,carbonitrides,and *** materials exhibit intriguing chemical and physical properties,including excellent electrical conductivity and a large surface area,making them attractive candidates for the hydrogen evolution reaction(HER).This scientific review explores recent advancements in MXene-based electrocatalysts for HER *** discusses various compositions,functionalities,and explicit design principles while providing a comprehensive overview of synthesis methods,exceptional properties,and electro-catalytic approaches for H_(2) production via electrochemical ***,challenges and future prospects in designing MXenes-based electrocatalysts with enhanced kinetics are highlighted,emphasizing the potential of incorporating different metals to expand the scope of electrochemical *** review suggests possible efforts for developing advanced MXenes-based electrocatalysts,particularly for efficient H_(2) generation through electrochemical water-splitting reactions..

关键词： MXenes Electrocatalyst Water Splitting Hydrogen Generation Clean Energy

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Cadaverine and putrescine exposure influence carbon and nitrogen cycling genes in water and sediment of the Yellow River

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Journal of Environmental Sciences 2024年第8期142卷 236-247页

作者： Wanghong Su Qiaoling Yu Jiawei Yang Qian Han Sijie Wang Petr Hedenec Xiaochen Wang Ruijun Wan-Yan Huan Li School of Public Health Lanzhou UniversityLanzhou 730000China 2 Institute for Tropical Biodiversity and Sustainable DevelopmentUniversity Malaysia Terengganu21030Kuala NerusTerengganuMalaysia State Key Laboratory of Grassland Agro-ecosystems Center for Grassland MicrobiomeCollege of pastoral agriculture science and technology Lanzhou UniversityLanzhou 730000China

The response patterns of microbial functional genes involved in biogeochemical cycles to cadaver decay is a central topic of recent environmental ***,the response mechanisms and pathways of the functional genes associated with the carbon(C)and nitrogen(N)cycling to cadaveric substances such as cadaverine and putrescine remain *** study explored the variation of functional genes associated with C fixation,C degradation and N cycling and their influencing factors under cadaverine,putrescine and mixed *** results showed only putrescine significantly increased the alpha diversity of C fixation genes,while reducing the alpha diversity of N cycling genes in *** the C cycling,the mixed treatment significantly decreased the total abundance of reductive acetyl-CoA pathway genes(i.e.,acsB and acsE)and lig gene linked to lignin degradation in water,while only significantly increasing the hydroxypropionate-hydroxybutylate cycle(i.e.,accA)gene abundance in *** the N cycling,mixed treatment significantly decreased the abundance of the nitrification(i.e.,amoB),denitrification(i.e.,nirS3)genes in water and the assimilation pathway gene(i.e.,gdhA)in *** factors(i.e.,total carbon and total nitrogen)were all negatively associated with the genes of C and N ***,cadaverine and putrescine exposure may inhibit the pathway in C fixation and N cycling,while promoting C *** findings can offer some new insight for the management of amine pollution caused by animal cadavers.

关键词： Carbon cycling Nitrogen cycling Cadaverine Putrescine Pollution management

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Multiscale observation in wide-spatial radar surveillance based on coherent FDA design

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Science China(Information Sciences) 2024年第2期67卷 232-252页

作者： Lei YU Feng HE Yi SU College of Electronics Science National University of Defense Technology

Wide-spatial radar surveillance missions are challenging tasks, requiring an increased power budget and agility in transmission aimed at extracting information from multiple targets in different environments. These requirements necessitate high transmitting degrees of freedom(DOF) to achieve the objective of multiscale observation for specific tasks in specialized regions of interest. Herein, we exploit the multiscale observation ability in wide-spatial radar surveillance based on frequency diverse array(FDA)radar. The proposed method facilitates spatial anisotropic control of multiple radar resources, including the transmitting waveforms, beampattern, and bandwidth. By utilizing a coherent FDA radar, we offer principles for the selection of baseband waveforms, in addition to the quantitative design of the beampattern gain and optimal bandwidth from the perspective of detection. The feasibility of the proposed method is validated through numerical experiments, thus indicating the potential in wide-spatial radar surveillance. Moreover,this work can be regarded as a preliminary attempt to gauge the efficacy of the computational array, a novel academic concept.

关键词： multi-scale observation wide-spatial surveillance frequency diverse array (FDA) beampattern synthesis frequency diversity gain computational array

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A review of MXene-derived quantum dots:Synthesis,characterization,properties,and applications

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Particuology 2024年第8期91卷 50-71页

作者： Chunhe Zhou Kar Ban Tan Wenjuan Han Li Wang Ming Lu The Joint Laboratory of MXene Materials Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of EducationJilin Normal UniversityChangchunJilin 130103China Department of Chemistry Faculty of ScienceUniversiti Putra MalaysiaSerdangSelangor 43400Malaysia

Cutting MXene to a minimum size and forming the derived two-dimensional MXene quantum dots(MQDs),which possess a unique intrinsic layered geometry structure,restricts exciton due to their novel spatial *** gives rise to a broad spectrum of fascinating properties,rendering them for various ***,the correlation between composition,structure,and processing control of MQDs is investigated systematically,giving further insight into the intrinsic and extrinsic *** review also provides an opportunity to explore new compositions,modify the properties,and tailor MQDs into the guided architectural design before any prospective applications.

关键词： MXene Quantum dots Characterization Properties Applications

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Randomization Strategies in Image Steganography Techniques:A Review

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Computers, Materials & Continua 2024年第8期80卷 3139-3171页

作者： AFM Zainul Abadin Rossilawati Sulaiman Mohammad Kamrul Hasan Center for Cyber Security Faculty of Information Science and TechnologyUniversiti Kebangsaan Malaysia(UKM)BangiSelangor43600Malaysia Department of Information and Communication Engineering Pabna University of Science and TechnologyPabna6600Bangladesh

Image steganography is one of the prominent technologies in data hiding *** system performance mostly depends on the embedding *** goal is to embed strictly confidential information into images without causing perceptible changes in the original *** randomization strategies in data embedding techniques may utilize random domains,pixels,or region-of-interest for concealing secrets into a cover image,preventing information from being discovered by an *** implementation of an appropriate embedding technique can achieve a fair balance between embedding capability and stego image imperceptibility,but it is challenging.A systematic approach is used with a standard methodology to carry out this *** review concentrates on the critical examination of several embedding strategies,incorporating experimental results with state-of-the-art methods emphasizing the robustness,security,payload capacity,and visual quality metrics of the stego *** fundamental ideas of steganography are presented in this work,along with a unique viewpoint that sets it apart from previous works by highlighting research gaps,important problems,and ***,it offers a discussion of suggested directions for future study to advance and investigate uncharted territory in image steganography.

关键词： Information hiding image steganography randomized embedding techniques payload capacity imperceptibility

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Brightness enhancement on random-distributed-feedback Raman fiber lasers pumped by multimode diodes

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High Power Laser Science and Engineering 2024年第3期12卷 69-76页

作者： Xiulu Hao Chenchen Fan Yang Li Zhiyong Pan Jinyong Leng Tianfu Yao Bing Lei Pu Zhou College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangshaChina Nanhu Laser Laboratory National University of Defense TechnologyChangshaChina

The power scaling on short wavelength(SW)fiber lasers operating around 1μm are in significant demand for applications in energy,environment and *** challenge for performance scalability of high-power SW lasers based on rare-earth-doped fiber primarily lies in the physical limitations,including reabsorption,amplified spontaneous emission and parasitic laser ***,we demonstrate an all-fiberized,purely passive SW(1018 nm)randomdistributed-feedback Raman fiber laser(RRFL)to validate the capability of achieving high-power output at SWs based on multimode laser diodes(LDs)direct *** pumped by multimode LDs,the high-brightness RRFL delivers over 656 W,with an electro-optical efficiency of 20%relative to the *** slope efficiency is 94%.The beam quality M2factor is 2.9(which is~20 times that of the pump)at the maximum output signal power,achieving the highest brightness enhancement of 14.9 in *** the best of our knowledge,this achievement also represents the highest power record of RRFLs utilizing multimode diodes for direct *** work may not only provide a new insight into the realization of high-power,high-brightness RRFLs but also is a promising contender in the power scaling of SWs below 1μm.

关键词： fiber laser purely passive gain random distributed feedback stimulated Raman scattering

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Two-Stage IoT Computational Task Offloading Decision-Making in MEC with Request Holding and Dynamic Eviction

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Computers, Materials & Continua 2024年第8期80卷 2065-2080页

作者： Dayong Wang Kamalrulnizam Bin Abu Bakar Babangida Isyaku Department of Computer Science Faculty of ComputingUniversiti Teknologi MalaysiaJohor BahruJohor81310Malaysia Department of Computer Science Faculty of Information Communication TechnologySule Lamido UniversityJigawa741103Nigeria

The rapid development of Internet of Things(IoT)technology has led to a significant increase in the computational task load of Terminal Devices(TDs).TDs reduce response latency and energy consumption with the support of task-offloading in Multi-access Edge Computing(MEC).However,existing task-offloading optimization methods typically assume that MEC’s computing resources are unlimited,and there is a lack of research on the optimization of task-offloading when MEC resources are *** addition,existing solutions only decide whether to accept the offloaded task request based on the single decision result of the current time slot,but lack support for multiple retry in subsequent time *** is resulting in TD missing potential offloading opportunities in the *** fill this gap,we propose a Two-Stage Offloading Decision-making Framework(TSODF)with request holding and dynamic *** Short-Term Memory(LSTM)-based task-offloading request prediction and MEC resource release estimation are integrated to infer the probability of a request being accepted in the subsequent time *** framework learns optimized decision-making experiences continuously to increase the success rate of task offloading based on deep learning *** results show that TSODF reduces total TD’s energy consumption and delay for task execution and improves task offloading rate and system resource utilization compared to the benchmark method.

关键词： Decision making internet of things load prediction task offloading multi-access edge computing

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A nerve-like self-healable conductive wire

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national Science Review 2024年第6期11卷 89-90页

作者： Xuemei Fu Benjamin C.K.Tee Department of Materials Science and Engineering National University of Singapore Institute for Health Innovation and Technology National University of Singapore

In wearables and robotics, it is often required to deploy electronic devices at different spatially distributed locations for multi-functionality [1–3]. Thus, conductive wires for efficient interconnection of various electronic devices are ***, in practical applications, the frequent motion of wearers and robots will result in high-strain deformations of these wires, which could cause irreparable damage.

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Beamforming design for covert broadcast communication with hidden adversary

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Science China(Information Sciences) 2024年第6期67卷 384-398页

作者： Weiyu CHEN Haiyang DING Shilian WANG Junshan LUO Fengkui GONG College of Electronic Science and Technology National University of Defense Technology College of Information and Communication National University of Defense Technology State Key Laboratory of Integrated Service Networks Xidian University

This paper explores covert broadcast communication in a challenging situation in which the transmitter, Alice, faces uncertainty regarding the position of the passive adversary, Willie. In this situation,controlling the signal exposure becomes difficult. Specifically, this paper focuses on the cases where Alice can delimit the suspicious areas where Willie may be located. The suspicious areas can have arbitrary number and shapes. Under the Rician fading model, the analytical expression of Willie's detection performance is derived. Then, the transmit power, the beamforming direction, and the number of channel uses are jointly designed to minimize the optimal Willie's detection performance among all the possible positions of Willie, on the premise of satisfying receivers' quality-of-service requirements. To tackle the formulated knotty problem with an infinite number of irregular and discontinuous Willie's possible positions, the continuous nature of the antenna pattern is exploited to convert the original problem into the one with a finite number of possible positions, by sampling the suspicious areas. Then, different algorithms are developed to address the resultant non-convex optimization problem for single-antenna Willie and multi-antenna Willie, respectively. Numerical results demonstrate significant performance gains of the proposed scheme over the widely-adopted maximum ratio transmission scheme, which indicates that simply adjusting the main lobe towards the receiver is indeed far away from optimum and shows the importance of leveraging Alice's limited knowledge of Willie's position.

关键词： low-probability-of-detection communication multiple antennas covertness performance uncertain position parameters optimization

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