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Fecal microbiota transplantation in allergic diseases

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World Journal of Methodology 2025年第2期15卷 83-91页

作者： Ece TüsüzÖnata ÖnerÖzdemir division of pediatric Allergy and Immunology Medical FacultySakarya UniversityAdapazarı54100SakaryaTürkiye

Microorganisms such as bacteria,fungi,viruses,parasites living in the human intestine constitute the human intestinal *** refers to composi-tional and quantitative changes that negatively affect healthy gut *** recent years,with the demonstration that many diseases are associated with dysbiosis,treatment strategies targeting the correction of dysbiosis in the treat-ment of these diseases have begun to be *** microbiota trans-plantation(FMT)is the process of transferring faeces from a healthy donor to another recipient in order to restore the gut microbiota and provide a therapeutic *** studies have gained popularity after probiotic,prebiotic,symbiotic studies in the treatment of dysbiosis and related *** has emerged as a potential new therapy in the treatment of allergic diseases as it is associated with the maintenance of intestinal microbiota and immunological balance(T helper 1/T helper 2 cells)and thus suppression of allergic *** this article,the definition,application,safety and use of FMT in allergic diseases will be discussed with current data.

关键词： Microbiota Dysbiosis Faecal microbiota transplantation Allergic diseases

Frequency and safety of COVID-19 vaccination in children with multisystem inflammatory syndrome:a telephonic interview-based analysis

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World Journal of pediatrics 2022年第10期18卷 700-705页

作者： Kubra Aykac Kubra Ozturk Osman Oguz Demir Dilan Demir Gumus Sevgi Aslan Ela Cem Miray Yilmaz Celebi Mustafa Dogan Karabacak Gulsum Alkan Fatma Dilsad Aksoy Burcu Ceylan Cura Yayla Eda Kepenekli Solmaz Celebi Melike Emiroglu Ilker Devrim Ali Bulent Cengiz Mehmet Ceyhan Yasemin Ozsurekci Faculty of Medicine Department of Pediatric Infectious DiseasesHacettepe UniversityAnkaraTurkey Goztepe Prof.Dr.Suleyman Department of Pediatric RheumatologyYalcın City HospitalIstanbulTurkey Faculty of Medicine Department of Pediatric DiseasesHacettepe UniversityAnkaraTurkey Department of pediatric infectious diseases Marmara University School of MedicineIstanbulTurkey Department of pediatric infectious diseases Dr.Behçet Uz Children’s HospitalízmirTurkey Faculty of Medicine Department of Pediatric Infectious DiseasesSelcuk UniversityKonyaTurkey Faculty of Medicine Department of Pediatric Infectious DiseasesUludag UniversityBursaTurkey Department of pediatric infectious diseases University of Health Science Ankara Training and Research HospitalAnkaraTurkey

Coronavirus disease 2019(COVID-19)vaccines are currently approved or authorized to prevent serious outcomes,such as severe disease,hospitalization,and *** Pfizer-BioNTech vaccine is recommended for everyone aged five and older in the United States(US)to prevent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection[1,2].However,it is unclear whether children with a history of multisystem,inflammatory syndrome in children(MIS-C)may be at risk for a MIS-like response following COVID-19 vaccination or SARS-CoV-2 reinfection[2].Therefore,physicians remain uncertain about vaccinating children with a history of *** study investigates the occurrence of severe,systemic side effects of COVID-19 vaccines and the recurrence of the MIS-C symptoms in children with a history of MIS-C to overcome vaccine hesitancy.

关键词： vaccination vaccine Pfizer

Concentrations of gastric mucosal cytokines in children with food allergy and Helicobacterpylori infection

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World Journal of Gastroenterology 2005年第43期11卷 6751-6756页

作者： El(z|.)bieta Maciorkowska Anatol Panasiuk Maciej Kaczmarski Department of pediatric Nursing Department of infectious diseases 3rd Department of Children's diseases

AIM： To measure the concentrations of chosen cytokines in the antrum mucosa depending on the kind of harmful pathogenic factors and to compare the concentrations with the values of controls without allergy and coexisting Helicobacter pylori （H pylori） infection. METHODS： The patients （97 children） were divided into three groups according to the data obtained from the case history, to the main cause of the disease and to the dominant clinical symptoms. Group Ⅰ： children with food allergy （Fa）; group Ⅱ： children infected with H pylori; group Ⅲ （control group）： children with functional disorders of the alimentary tract （without Fa and Hp infection）. H pylori infection was determined by the presence of anti-Hp antibodies in serum （ELISA method） and urease test performed during endoscopic examination. Cytokine concentration in homogenates of gastric mucosa was detected by ELISA method. RESULTS： The IL-2 concentration in gastric mucosa bioptates was the highest in children with Hp infection （116.5±179.5 pg/mg of the protein） and Fa and Hp infection （98.1±101.0 pg/mg）, while decreased in children with Fa （44.8±50.3 pg/mg） and controls （45.7±23.5 pg/mg）. The lowest mean concentration of IFN-y was observed in children with Hp infection （18.9±16.4 pg/mg）, with Fa and Hp infection （25.5±27.7 pg/mg）, with Fa （40.6±39.7 pg/mg） and controls （49.9±33.4 pg/mg）. The highest IL-4 concentrations were observed in children with Hp infection （35.3±52.8 pg/mg） and in children with Fa and Hp infection （37.2±51.7 pg/mg）, while lower IL-4 concentration （23.64-35.8 pg/mg） was found in children with Fa compared to the controls （22.7±13.8 pg/mg）. The analysis of IL-4 concentrations in children with Hp infection regarding the intensity of gastritis showed the highest value （62.2±61.2 pg/mg） in mild and moderate gastritis. The concentrations of IL-5 in the gastric mucosa of children with or without Fa did not differ significantly and were comparable to the control group. The highest mean IL-8 val

关键词： Mucosal cytokines Food allergy Helicobacterpylori dehydrogenase complex

Phagocytic and oxidative burst activity of neutrophils in the end stage of liver cirrhosis

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World Journal of Gastroenterology 2005年第48期11卷 7661-7665页

作者： Anatol Panasiuk Jolanta Wysocka Elzbieta Maciorkowska Bozena Panasiuk Danuta Prokopowicz Janusz Zak Karol Radomski Department of infectious diseases Department of pediatrics Diagnostics Department of pediatric Nursing

AIM：To evaluate the phagocytic activity and neutrophil oxidative burst in liver ***： In 45 patients with advanced postalcoholic liver cirrhosis （aged 45±14 years） and in 25 healthy volunteers （aged 38±5 years）, the percentage of phagocytizing cells after in vitro incubation with E. coli （Phagotest Kit）, phagocytic activity （mean intensity of fluorescence, MIF） and the percentage of neutrophil oxidative burst （Bursttest Kit）, and the level of free oxygen radical production （MIF of Rodamine 123） were analyzed by flow cytometry. The levels of soluble sICAM-1, sVCAM-1, sP-selectin, sE-selectin, sL-selectin, and TNF-α were determined in blood ***： The percentage of E. coli phagocytizing neutrophils in liver cirrhosis patients was comparable to that in healthy subjects. MIF of neutrophil - ingested E. coli was higher in patients with liver cirrhosis. The oxidative burst in E. coli phagocytizing neutrophils generated less amount of active oxygen compounds in liver cirrhosis pa- tients （MIF of R123：24.7±7.1 and 29.7±6.6 in healthy, P〈0.01）. Phorbol myristate acetate （PMA） - stimulated neutrophilsproduced less reactive oxidants in liver cirrhosis patients than in healthy subjects （MIF of R123： 42.7±14.6 vs 50.2±13.3, P〈0.01）. A negative correlation was observed between oxidative burst MIF of PMA-stimulated neutrophils and ALT and AST levels （r -0.35, P〈0.05; r-0.4, P〈0.03）. sVCAM-1, sICAM-1, sE-selectin concentrations correlated negatively with the oxygen free radical production （MIF of R123） in neutrophils after PMA stimulation in liver cirrhosis patients （r-0.45, P〈0.05, r-0.41, P〈0.05; r-0.39, P〈0.05, respectively）.CONCLUSION： Neutrophil metabolic activity diminishes together with the intensification of liver failure. The metabolic potential of phagocytizing neutrophils is significantly lower in liver cirrhosis patients, which can be one of the causes of immune mechanism damage. The evaluation of oxygen metabolism of E. coli-stimulated neutrophils

关键词： Neutrophil Phagocytosis Oxidative burst Liver cirrhosis Flow cytometry

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina division of infectious diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

Chryseobacterium/Elizabethkingia species infections in children

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Asian Pacific Journal of Tropical Medicine 2023年第6期16卷 268-275页

作者： Aysun Yahşi Gülsümİclal Bayhan Tuğba Erat Ahmet Yasin Güney Seval Özen Kübra Konca Belgin Gülhan Saliha Kanık Yüksek Aslınur Özkaya Parlakay Department of pediatric infectious diseases Ankara City HospitalAnkaraTurkey

Objective:To investigate the clinical and epidemiological features and outcome of Chryseobacterium and Elizabethkingia *** in children,together with antimicrobial ***:This retrospective study was conducted at a tertiary pediatric hospital in *** patients infected with Chryseobacterium/Elizabethkingia *** those presenting to Ankara City Hospital between March 2014 and March 2022 were ***:A total of 49 cases were included and 29 cases were identified as *** median age was 14(0.2-185.0)*** majority(89.8%)of these patients had an underlying disease,including malignancy(42.9%).Bacteremia(46.9%)and central line-associated bloodstream infection(28.6%)were the most common *** thirty-day all-cause mortality rate was 12.2%.The most commonly used antibiotics were ciprofloxacin and trimethoprim-sulfamethoxazole(TMP-SMX).Forty-five(91.8%)isolates were susceptible to ciprofloxacin,44(91.6%)to TMP-SMX,and 21(87.5%)to ***:Chryseobacterium and Elizabethkingia *** emergent,nosocomial pathogens and the majority of cases were older than the neonatal *** were mainly seen in patients with long hospital stays,indwelling devices,and those who have received antibiotics within the last month,especially *** addition,they were associated with bloodstream infection and *** most commonly useful antibiotics according to the resistance patterns were ciprofloxacin and TMP-SMX.

关键词： Chryseobacterium Elizabethkingia Flavobacteriaceae Weeksellaceae

Soluble adhesion molecules ICAM-1,VCAM-1,P-selectin in children with Helicobacter pylori infection

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World Journal of Gastroenterology 2005年第43期11卷 6745-6750页

作者： Elzbieta Maciorkowska Maciej Kaczmarski Anatol Panasiuk Katarzyna Kondej-Muszynska Andrzej Kemonai Department of pediatric Nursing 3rd Department of Children's diseases Department of infectious diseases Department of Pathomorphology

AIM: To assess the sICAM-1, sVCAM-1, and sP-selectin levels in children withHelicobacter pylori(H pylori)infection and to evaluate their significance for the morphological changes found in gastric ***: The study included 106 children: 59children (55.7%) with chronic gastritis and positive IgG against H pylori, 29 children (27.3%) after previous H pylori infection without the bacterium colonization but with positive IgG against H pylori, and 18 children (17%) with functional disorders of the gastrointestinal system but with normal IgG against H pylori. Endoscopic and histopathological evaluation of gastric mucosa was performed based on the Sydney System *** evaluation of sP-selectin, sIC AM-1, sVCAM-1 levels in the sera of children was carried out using ELISA ***: The assessment of gastritis activity degrees indicated statistically significant values in the antrum and corpus (P＜0.001) of children examined. Serum sVCAM-1 levels were higher in group with gastritis due to H pylori infection than in group without infection and differed statistically (P＜0.05). Serum sVCAM-1 levels proved to be the highest among other adhesive molecules in infected children and decreased after eradication of H pylori. Serum sICAM-1 levels were similar in all examined groups. Serum sP-selectin levels were similar in children with and without H pylori ***: Assessment of adhesive molecules (sPselectin, sICAM-1, sVCAM-1) in the sera of children with active H pylori infection can show the participation of sVCAM-1 in the pathogenesis of gastric mucosal inflammation, sP-selectin and sICAM-1 concentrations in the sera of children with H pylori infection after eradication cannot reveal any significant differences as compared to healthy children.

关键词： sVCAM-1 sICAM-1 sP-selectin Helicobacter pylori

Direct anti-HCV agents

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Acta Pharmaceutica Sinica B 2016年第1期6卷 26-31页

作者： Xingquan Zhang division of infectious diseases University of CaliforniaSan Diego School of Medicine

Unlike human immunodeficiency virus(HIV)and hepatitis B virus(HBV),hepatitis C virus(HCV)infection is a curable *** direct antiviral agent(DAA)targets are focused on HCV NS3/4A protein(protease),NS5 B protein(polymerase)and NS5 A *** first generation of DAAs includes boceprevir and telaprevir,which are protease inhibitors and were approved for clinical use *** cure rate for genotype 1 patients increased from 45% to 70% when boceprevir or telaprevir was added to standard PEG-IFN/*** effective and less toxic second generation DAAs supplanted these drugs by *** second generation of DAAs includes sofosbuvir(Sovaldi),simeprevir(Olysio),and fixed combination medicines Harvoni and Viekira *** drugs increase cure rates to over 90%without the need for interferon and effectively treat all HCV *** these drugs the "cure HCV"goal has become a *** remain about drug resistance mutations and the high cost of these *** investigation of new HCV drugs is progressing rapidly;fixed dose combination medicines in phase III clinical trials include Viekirax,asunaprevirtdaclatasvirtbeclabuvir,grazoprevirtelbasvir and others.

关键词： Hepatitis C virus Cure HCV Sustained virologic response Direct antiviral agents NS3/4A protease inhibitor

New insight of vitamin D in chronic liver diseases

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Hepatobiliary & Pancreatic diseases International 2014年第6期13卷 580-585页

作者： En-Qiang Chen Ying Shi Hong Tang Center of infectious diseases West China Hospital and division of infectious diseases State Key Laboratory of BiotherapySichuan University

BACKGROUND： Vitamin D is a fat-soluble sterol derivative that is predominantly synthesized in the liver and has multiple functions. The accumulative data showed that the clinical manifestations and prognosis of chronic liver diseases are associated with serum vitamin D levels. DATA SOURCES： A PubMed and Google Scholar search using terms：＂vitamin D＂, ＂25 （OH）D＂, ＂liver disease＂, ＂viral hepatitis＂, ＂non-alcoholic fatty liver disease＂, ＂liver fibrosis＂, ＂cirrhosis＂, ＂hepatocellular carcinoma＂ and ＂autoimmune liver disease＂ was performed, and relevant articles published in English between January 2000 and March 2014 were reviewed. Fulb text publications relevant to the field were selected and relevant articles from reference lists were also included. RESULTS： The insufficiency or deficiency of vitamin D is common in various kinds of chronic liver diseases including viral hepatitis B and C. Serum 25-hydroxyvitamin D and vitamin D receptors are possibly interrelated with the incidence, treatment and prognosis of diseases. Though the evidence of vitamin D supplementation in viral hepatitis and associated liver diseases is still limited, there is great potential to apply this adjuvant therapy to improve the treatments. CONCLUSIONS： Although the exact role and mechanisms of vitamin D have not been fully elucidated in chronic liver diseases, it is potentially beneficial in the treatment of chronic liver diseases. Further mechanistic studies are needed to validate its clinical application.

关键词： vitamin D deficiency viral hepatitis chronic liver diseases