Soluble adhesion molecules ICAM-1,VCAM-1,P-selectin in children with Helicobacter pylori infection
Soluble adhesion molecules ICAM-1,VCAM-1,P-selectin in children with Helicobacter pylori infection作者机构：Department of Pediatric Nursing 3rd Department of Children's Diseases Department of Infectious Diseases Department of Pathomorphology
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2005年第11卷第43期
页 面：6745-6750页
核心收录：
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
主 题：sVCAM-1 sICAM-1 sP-selectin Helicobacter pylori
摘 要：AIM: To assess the sICAM-1, sVCAM-1, and sP-selectin levels in children withHelicobacter pylori(H pylori)infection and to evaluate their significance for the morphological changes found in gastric ***: The study included 106 children: 59children (55.7%) with chronic gastritis and positive IgG against H pylori, 29 children (27.3%) after previous H pylori infection without the bacterium colonization but with positive IgG against H pylori, and 18 children (17%) with functional disorders of the gastrointestinal system but with normal IgG against H pylori. Endoscopic and histopathological evaluation of gastric mucosa was performed based on the Sydney System *** evaluation of sP-selectin, sIC AM-1, sVCAM-1 levels in the sera of children was carried out using ELISA ***: The assessment of gastritis activity degrees indicated statistically significant values in the antrum and corpus (P0.001) of children examined. Serum sVCAM-1 levels were higher in group with gastritis due to H pylori infection than in group without infection and differed statistically (P0.05). Serum sVCAM-1 levels proved to be the highest among other adhesive molecules in infected children and decreased after eradication of H pylori. Serum sICAM-1 levels were similar in all examined groups. Serum sP-selectin levels were similar in children with and without H pylori ***: Assessment of adhesive molecules (sPselectin, sICAM-1, sVCAM-1) in the sera of children with active H pylori infection can show the participation of sVCAM-1 in the pathogenesis of gastric mucosal inflammation, sP-selectin and sICAM-1 concentrations in the sera of children with H pylori infection after eradication cannot reveal any significant differences as compared to healthy children.
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