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Exploring the genetic basis of pre-harvest sprouting in rice through a genome-wide association study-based haplotype analysis

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Journal of Integrative Agriculture 2024年第8期23卷 2525-2540页

作者： Myeong-Hyeon Min Aye Aye Khaing Sang-Ho Chu Bhagwat Nawade Yong-Jin Park department of Plant Resources College of Industrial SciencesKongju National UniversityYesan 32439Republic of Korea department of Agronomy Yezin Agricultural UniversityNay Pyi Taw 15013Myanmar

Pre-harvest sprouting(PHS)poses a significant global challenge to cereal production,impacting both yield and *** this study,we employed genome-wide association studies(GWAS)on diverse rice accessions to identify novel PHS-associated *** assessment of 127 cultivated accessions for panicle germination(PHS)and detached grain germination(germination rate of detached grains at the 14th day(D14))revealed considerable phenotypic variation among rice *** analysis identified 91 significant signals at–log10(P-value)>5,including 15SNPs for PHS and 76 SNPs for D14.A subsequent linkage disequilibrium(LD)block-based GWAS analysis detected 227 significant SNPs for both traits,consisting of 18 nonsynonymous substitutions located on the coding regions of nine *** haplotype analysis identified 32 haplotypes,with 10 specific to cultivated accessions,19 specific to the wild type,and three shared between them.A phenotypic assessment of major haplotypes revealed significant differences between resistant(Hap1 and Hap2)and susceptible haplotypes(Hap5,Hap27,and Hap28),distinguished by a G/A SNP within a novel gene,*** identified haplotypes offer promising prospects for haplotypebased breeding aimed at enhancing PHS resistance in rice.

关键词： rice PHS dormancy germination GWAS haplotype abiotic stress

General anesthetic agents induce neurotoxicity through astrocytes

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Neural Regeneration Research 2024年第6期19卷 1299-1307页

作者： Yanchang Yang Tiantian Liu Jun Li Dandan Yan Yuhan Hu Pin Wu Fuquan Fang Patrick M.McQuillan Wenxin Hang Jianhang Leng Zhiyong Hu department of Anesthesiology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina department of Anesthesiology Ningbo Women and Children’s HospitalNingboZhejiang ProvinceChina department of Anesthesiology Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhouZhejiang ProvinceChina Cell Biology department Yale UniversityNew HavenCTUSA department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPAUSA department of Central Laboratory Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial *** studies,however,have focused on the effects of general anesthetic agents on neuroglia or *** can also be an important target of general anesthetic agents as they exert not only sedative,analgesic,and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive ***,we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes,and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes,in addition to acting on the receptors on their surface,which not only affect Ca^(2+)signaling,inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes,but are even involved in the regulation of the pro-and anti-inflammatory processes of *** would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons,other neuroglia,and vascular *** this review,we summarize how general anesthetic agents act on neurons via astrocytes,and explore potential mechanisms of action of general anesthetic agents on the nervous *** hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关键词： astrocytes brain-derived neurotrophic factor general anesthetic agents neuron neurotoxicity N-methyl-D-aspartate receptor perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor

Recent Developments in Authentication Schemes Used in Machine-Type communication Devices in Machine-to-Machine communication: Issues and Challenges

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Computers, Materials & Continua 2024年第4期79卷 93-115页

作者： Shafi Ullah Sibghat Ullah Bazai Mohammad Imran Qazi Mudassar Ilyas Abid Mehmood Muhammad Asim Saleem Muhmmad Aasim Rafique Arsalan Haider Ilyas Khan Sajid Iqbal Yonis Gulzar Kauser Hameed department of Computer Engineering Balochistan University of Information TechnologyEngineering and Management SciencesQuetta87300Pakistan department of Information Technology Balochistan University of Information TechnologyEngineeringand Management SciencesQuetta87300Pakistan department of Information Systems College of Computer Sciences and Information TechnologyKing Faisal UniversityHofuf in Al-Ahsa31982Saudi Arabia department of Management Information Systems College of Business AdministrationKing Faisal UniversityHofuf in Al-Ahsa31982Saudi Arabia department of Software Engineering College of ComputingRiphah International UniversityFaisalabad44000Pakistan department of Electrical Engineering Balochistan University of Information Technology Engineeringand Management SciencesQuetta87300Pakistan department of Mathematics College of Science Al-ZulfiMajmaah UniversityAl-Majmaah11952Saudi Arabia

Machine-to-machine (M2M) communication plays a fundamental role in autonomous IoT (Internet of Things)-based infrastructure, a vital part of the fourth industrial revolution. Machine-type communication devices(MTCDs) regularly share extensive data without human intervention while making all types of decisions. Thesedecisions may involve controlling sensitive ventilation systems maintaining uniform temperature, live heartbeatmonitoring, and several different alert systems. Many of these devices simultaneously share data to form anautomated system. The data shared between machine-type communication devices (MTCDs) is prone to risk dueto limited computational power, internal memory, and energy capacity. Therefore, securing the data and devicesbecomes challenging due to factors such as dynamic operational environments, remoteness, harsh conditions,and areas where human physical access is difficult. One of the crucial parts of securing MTCDs and data isauthentication, where each devicemust be verified before data transmission. SeveralM2Mauthentication schemeshave been proposed in the literature, however, the literature lacks a comprehensive overview of current M2Mauthentication techniques and the challenges associated with them. To utilize a suitable authentication schemefor specific scenarios, it is important to understand the challenges associated with it. Therefore, this article fillsthis gap by reviewing the state-of-the-art research on authentication schemes in MTCDs specifically concerningapplication categories, security provisions, and performance efficiency.

关键词： Authentication cyber security internet of things machine-type communication devices machine-to-machine communication

Sex differences in human pre-gastrulation embryos

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Science China Life Sciences 2024年

作者： Yongjie Lu Meng Qin Xintong Qi Ming Yang Fan Zhai Jiaqi Zhang Zhiqiang Yan Liying Yan Jie Qiao Peng Yuan State Key Laboratory of Female Fertility Promotion Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Academy for Advanced Interdisciplinary studies Peking University

Human fetuses exhibit notable sex differences in growth rate and response to the intrauterine environment, yet their origins and underlying mechanisms remain uncertain. Here, we conduct a detailed investigation of sex differences in human pre-gastrulation embryos. The lower methylation and incomplete inactivation of the X chromosome in females, as well as the sex-specific cell-cell communication patterns,contribute to sex-differential transcription. Male trophectoderm is more inclined toward syncytiotrophoblast differentiation and exhibits a stronger hormone secretion capacity, while female trophectoderm tends to retain cytotrophoblast program with stronger mitochondrial function as well as higher vasculogenesis and immunotolerance signals. Male primitive endoderm initiates the anterior visceral endoderm transcriptional program earlier than females. The cell cycle activities of the epiblast and primitive endoderm are higher in males compared to females, while the situation is opposite in the trophectoderm. In conclusion, our study provides in-depth insights into the sex differences in human pre-gastrulation embryos and contributes to unraveling the origins of the sex differences in human fetal development.

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Discourse analysis of knowledge-based live streaming:a case study of East Buy streamer Dong Yuhui

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Language and Semiotic studies 2024年第2期10卷 222-244页

作者： Yehui Song Junhua Mo Korean department Soochow UniversitySuzhou215006China English department Soochow UniversitySuzhouChina

Live streaming e-commerce is not only an important part of China’s digital economy but also the preferred way of purchase for many Chinese,especially the *** 2022,a new model initiated by East Buy has emerged,quickly becoming known as knowledge-based live *** most famous streamer from this novel type of live streaming is Dong Yuhui,a former English teacher of the New Oriental *** a top Internet influencer with millions of followers,Dong Yuhui has become a conspicuous social sign of the rising China that is undergoing fast technological,economic,and cultural *** study thus takes Dong Yuhui as an example to examine the typical discourses of the knowledge-based live *** a triangulation of case study,discourse analysis,and sentiment analysis,it finds that Dong Yuhui mainly employs the strategies of disseminating encyclopedic knowledge,telling intriguing stories,and using poetic language in his live streaming *** unique discourse has the main function of fulfilling customers’intellectual,emotional,and psychological *** such,it is warmly received by customers,whose comments are centered on the talents of the streamer rather than the attributes of the commodity.

关键词： knowledge-based live streaming Dong Yuhui typical discourses major strategies main functions customer comments

Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

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Chinese Journal of Integrative Medicine 2024年第1期30卷 75-84页

作者： Anchal Trivedi Adria Hasan Rumana Ahmad Sahabjada Siddiqui Aditi Srivastava Aparna Misra Snober S.Mir department of Biochemistry Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology Laboratory Integral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India department of Biotechnology Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India department of Biosciences Faculty of ScienceIntegral UniversityLucknow(226026)India

Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.

关键词： myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine

Mobile Alert and Warning in the United States and Japan:Confronting the Challenges of International Harmonization

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International Journal of Disaster Risk Science 2021年第6期12卷 928-934页

作者： Hamilton Bean Ana Maria Cruz Mika Shimizu Keri K.Stephens Matthew McGlone Sharon Strover department of communication University of ColoradoDenver.CO 80204USA Disaster Prevention Research Institute(DPRI).Kyoto University Kyoto 611-0011Japan Graduate School of Advanced Integrated studies in Human Survivability Kyoto UniversityKyoto 606-8501Japan department of communication studies The University of Texas at AustinAustinTX 78712USA School of Journalism and Media The University of Texas at AustinAustinTX 78712USA

A U.S.-Japan expert workshop on mobile alert and warning was held online 8–10 September *** by the Japan Foundation’s Center for Global Partnership(CGP)and responding to the Sendai Framework for Disaster Risk Reduction 2015–2030,the workshop compared *** Japanese mobile alert and warning contexts,systems,policies,and messages to investigate possibilities for international harmonization of mobile device-based early *** workshop’s sessions revealed two interrelated issues that repeatedly surfaced among workshop participants:culture and *** workshop illuminated several possibilities and problems confronting U.S.,Japanese,and global stakeholders as they develop,deploy,and seek to improve the effectiveness of mobile alert and warning systems and messages.

关键词： Alerts Disasters Warning Japan Mobile technology United States

A multimodal analysis of Piggyvest's animated advertisement videos

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Language and Semiotic studies 2023年第2期9卷 263-289页

作者： Toluwani Deborah Odedeyi Temitope Michael Ajayi department of linguistics and African Languages University of IbadanIbadanNigeria

This study examines the persuasive strategies in selected animated advertisement videos by Piggyvest,the first and one of the fastest-growing online savings platforms in Nigeria,whose modus operandi is quite different from those of the conventional banking *** insights from Kress and van Leeuwen's(*** images:The grammar of visual design,2nd *** York:Routledge)Multimodal Discourse Analytic framework,12 samples of Piggyvest's animated videos(for advertisements)were randomly sampled out of the 30 videos initially purposively *** reveal metaphorisation of financial management and discipline,playing around gender-related ideas on finances,foregrounding of aspirations and financial decisions,depiction of cognitive strength and weakness on money matters,and striking a connection between money and relationships are persuasive strategies deployed in the animated advertisement videos by Piggyvest to appeal to their target audience.

关键词： animated videos multimodal discourse analysis online banking persuasion Piggyvest

Resource scheduling approach in cloud Testing as a Service using deep reinforcement learning algorithms

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CAAI Transactions on Intelligence Technology 2021年第2期6卷 147-154页

作者： Priyadarsini Karthik Karthik Sekhar department of Computer Science and Engineering Vels Institute of Science Technology and Advanced Studies(VISTAS)ChennaiIndia department of Electronics and communication Engineering College of Engineering and TechnologySRM Institute of Science and TechnologyVadapalani CampusChennaiIndia

Many organizations around the world use cloud computing Testing as Service(Taas)for their *** computing is principally based on the idea of on-demand delivery of computation,storage,applications,and additional *** depends on delivering user services through Internet *** addition,it uses a pay-as-you-go business design to deliver user *** offers some essential characteristics including on-demand service,resource pooling,rapid elasticity,virtualization,and measured *** are various types of virtualization,such as full virtualization,para-virtualization,emulation,〇S virtualization,and application *** scheduling in Taas is among the most challenging jobs in resource allocation to mandatory tasks/jobs based on the required quality of applications and *** of the cloud environment,uncertainty,and perhaps heterogeneity,resource allocation cannot be addressed with prevailing *** situation remains a significant concern for the majority of cloud providers,as they face challenges in selecting the correct resource scheduling algorithm for a particular *** authors use the emergent artificial intelligence algorithms deep RM2,deep reinforcement learning,and deep reinforcement learning for Taas cloud scheduling to resolve the issue of resource scheduling in cloud Taas.

关键词： Service cloud prevailing