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SPECIAL ISSUE： GLOBALIZATION AND CONTEMPORARY CHINESE CULTURAL CONSTRUCTION：Chinese culture： self-awareness and self-confidence

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Social Sciences in China 2008年第4期29卷 195-204页

作者： Cheng Guangyun center for Globalization and Cultural studies Department of Philosophy Capital Normal University

What we call cultural strength is actually the locus of cultural vitality; that is, culture existing not as object （target） but rather as subject. We need a new kind of cultural self-awareness and cultural self- confidence. Globalization has two aspects： internationalization and ＂worldization.＂ These attributes determine our two-fold task of developing and making use of international cultural resources to reconstruct Chinese culture, and of Chinese cultural resources to reconstruct world culture. At the same time, the dual nature of globalization also determines the duality of the cross-cultural. Here we find the very grounds for China＇s strategy for cultural development to deal with globalization.

关键词： cultural vitality internationalization "worldization " intercultural cross-cultural

Transmission potential of the novel coronavirus (COVID-19) onboard the diamond Princess Cruises Ship, 2020

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Infectious Disease Modelling 2020年第1期5卷 264-270页

作者： Kenji Mizumoto Gerardo Chowell Graduate School of Advanced Integrated studies in Human Survivability Kyoto University Yoshida-Nakaadachi-choSakyo-kuKyotoJapan Hakubi center for Advanced Research Kyoto UniversityYoshidahonmachiSakyo-kuKyotoJapan Department of Population Health Sciences School of Public HealthGeorgia State UniversityAtlantaGeorgiaUSA Division of International Epidemiology and Population studies Fogarty International CenterNational Institutes of HealthBethesdaUSA

An outbreak of COVID-19 developed aboard the Princess Cruises Ship during January eFebruary *** mathematical modeling and time-series incidence data describing the trajectory of the outbreak among passengers and crew members,we characterize how the transmission potential varied over the course of the *** estimate of the mean reproduction number in the confined setting reached values as high as^11,which is higher than mean estimates reported from community-level transmission dynamics in China and Singapore(approximate range:1.1e7).Our findings suggest that Rt decreased substantially compared to values during the early phase after the Japanese government implemented an enhanced quarantine *** recent estimates of Rt reached values largely below the epidemic threshold,indicating that a secondary outbreak of the novel coronavirus was unlikely to occur aboard the Diamond Princess Ship.

关键词： Corona Epidemic Confined settings Cruise Next generation matrix

Polycarcin V induces DNA-damage response and enables the profiling of DNA-binding proteins

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National Science Review 2022年第11期9卷 19-28页

作者： Zongwei Yue Fan Wu Fusheng Guo Jiyeong Park Jin Wang Liyun Zhang Daohong Liao Wenyang Li Orlando D.Sch?rer Xiaoguang Lei Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationDepartment of Chemical BiologyCollege of Chemistry and Molecular Engineering Synthetic and Functional Biomolecules CenterPeking University Peking-Tsinghua center for Life Science Academy for Advanced Interdisciplinary Studies Peking University center for Genomic Integrity Institute for Basic Science Jiangsu JITRI Molecular Engineering Inst.Co. Ltd. Department of Biological Sciences School of Life Sciences Ulsan National Institute of Science and Technology Institute for Cancer Research Shenzhen Bay Laboratory

To maintain genomic integrity and avoid diseases, the DNA-damage response(DDR) not only detects and repairs DNA lesions, but also contributes to the resistance to DNA-damaging *** the DDR plays a significant role in drug discovery using the principle of synthetic lethality. The incomplete current knowledge of the DDR encouraged us to develop new strategies to identify and study its components and pathways. Polycarcin V, belonging to the C-aryl glycoside natural products, is a light-activatable DNA-intercalating agent that causes DNA damage by forming a covalent [2+2]cycloadduct with thymine residue under 365–450 nm of light irradiation in a DNA-sequence-independent manner. Taking advantage of the light-activatable feature and temporal control of DDR, we designed and synthesized polycarcin V-based bifunctional chemical probes, including one that cross-links DNA to DNA-binding protein to explore the DDR induced by polycarcin V and uncover novel DNA–protein interactions. Utilizing this chemical probe and activity-based protein profiling-stable isotope labeling with amino acids in cell culture, we identified 311 DNA-binding protein candidates, including known DDR factors and additional proteins that may be of interest in discovering new biology. We validated our approach by showing that our probe could specifically cross-link proteins involved in nucleotide excision repair(NER) that repair bulky DNA adducts. Our studies showed that the [2+2] cycloadduct formed by polycarcin V could indeed be repaired by NER in vivo. As a DNA-damaging agent, polycarcin V or its drug-like derivative plus blue light showed promising properties for psoriasis treatment, suggesting that it may itself hold promise for clinic applications.

关键词： polycarcin V [2+2] DNA photoadduct light-activatable chemical probe ABPP for DNA-binding protein proteomics psoriasis treatment

The Belt and Road and the Rediscovery of Reciprocity-Based Anthropology

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Social Sciences in China 2019年第1期40卷 171-185页

作者： Zhao Xudong Li Changjiang International Police studies, People’s Public Security University of China. center for Anthropological studies Renmin University of China School of International Police studies People’s Public Security University of China

Reciprocity has core significance for understanding basic human living conditions:our social nature is founded on reciprocal relations,and reciprocity strengthens the ties between ***-based anthropology is a kind of cultural logic,one that stresses the interaction between different ***,it involves studying forms of the mutually beneficial relations involved in complementary *** perspective reconciles differences,creating a communicative space for diverse cultures’coexistence,symbiosis and *** various channels formed through human activity include ways in and ways out,constant incomings and outgoings,the coexistence of different cultures,ways of life and ideas,and *** launching of the Belt and Road Initiative includes channels with multiple characteristics and functions,so research on this topic involves the analysis of society and culture based on roadways rather than locations.

关键词： reciprocity-based anthropology Belt and Road channel cultural corridor roadology

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Editorial

Frontiers of Literary studies in China-Selected Publications from Chinese Universities 2023年第3期17卷 1-2页

作者： WANG Yichuan center for Literary Theory studies Beijing Normal University Beijing 100091 China

The theme of this special issue is"How Is Traditional culture Integrated into Novels:A Study of Chen Yan's Works,"introducing the writer Chen Yan and his *** Yan can be regarded as a prodigy in the contemporary Chines... 详细信息

关键词： introducing literary contemporary

The Outsider Perspective: Classical Chinese Philosophy in the Narrative Framework of the European Enlightenment

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Contemporary Social Sciences 2021年第2期6卷 62-71页

作者： Fu Chun Wang Shuguang Sichuan Academy of Social Sciences University of Newcastle center for Cross-Cultural studies University of Newcastle

The purpose of this article is to enhance the understanding of how Classical Chinese Philosophy has been interpreted and transferred by Enlightenment thinkers into the narrative framework of European philosophy as a far-reaching source of ideas and inspiration with a driving force for promoting modern European social change. We examine outsider perspectives within the context of Enlightenment thinking that contributed to advances in the cross-cultural understanding of how Chinese stories could be disseminated in the framework of East-West dialogue.

关键词： Classical Chinese Philosophy the narrative framework of the European Enlightenment humanism rationalism liberalism secularism Eurocentrism cross-culture

Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells promote alveolar bone regeneration by regulating macrophage polarization

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Science China(Life Sciences) 2024年第5期67卷 1010-1026页

作者： Ziyue Qin Yanxing Han Yifei Du Yixuan Zhang Yifeng Bian Ruyu Wang Haoran Wang Fanyi Guo Hua Yuan Yongchu Pan Jianliang Jin Qigang Zhou Yuli Wang Feng Han Yan Xu Jiandong Jiang Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Jiangsu Province Engineering Research center of Stomatological Translational Medicine Nanjing 210029China State Key Laboratoryof BioactiveSubstances andFunction of Natural Medicine Instituteof Materia MedicaChinese Academyof MedicalSciencesandPeking Union MedicalCollegeBeijing100050China Gusu school Nanjing medical universitySuzhou 215002China Key Laboratory of Cardiovascular&Cerebrovascular Medicine Drug Target and Drug Discovery CenterSchool of PharmacyNanjing Medical UniversityNanjing 211166 China Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Department of Human Anatomy Research Centre for Bone and Stem CellsKey Laboratory for Aging&DiseaseThe State Key Laboratory of Reproductive MedicineNanjing Medical UniversityNanjing 211166China Department of Clinical Pharmacology School of PharmacyNanjing Medical UniversityNanjing Jiangsu211166China Department of Periodontology The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Department of Virology Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Alveolar bone regeneration has been strongly linked to macrophage polarization.M1 macrophages aggravate alveolar bone loss,whereas M2 macrophages reverse this ***(BBR),a natural alkaloid isolated and refined from Chinese medicinal plants,has shown therapeutic effects in treating metabolic *** this study,we first discovered that culture supernatant(CS)collected from BBR-treated human bone marrow mesenchymal stem cells(HBMSCs)ameliorated periodontal alveolar bone *** from the BBR-treated HBMSCs contained bioactive materials that suppressed the M1 polarization and induced the M2 polarization of macrophages in vivo and in *** clarify the underlying mechanism,the bioactive materials were applied to different animal *** discovered macrophage colony-stimulating factor(M-CSF),which regulates macrophage polarization and promotes bone formation,a key macromolecule in the *** of pure M-CSF attenuated experimental periodontal alveolar bone loss in ***-stimulating factor 1 receptor(CSF1R)inhibitor or anti-human M-CSF(M-CSF neutralizing antibody,Nab)abolished the therapeutic effects of the CS of BBR-treated ***,AKT phosphorylation in macrophages was activated by the CS,and the AKT activator reversed the negative effect of the CSF1R inhibitor or *** results suggest that the CS of BBR-treated HBMSCs modulates macrophage polarization via the M-CSF/AKT *** studies also showed that CS of BBR-treated HBMSCs accelerated bone formation and M2 polarization in rat teeth extraction ***,our findings established an essential role of BBR-treated HBMSCs CS and this might be the first report to show that the products of BBR-treated HBMSCs have active effects on alveolar bone regeneration.

关键词： berberine human bone marrow mesenchymal stem cells alveolar bone regeneration macrophage colony-stimulating factor AKT phosphorylation

Jadwar(Delphinium denudatum Wall.):a medicinal plant

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Traditional Medicine Research 2020年第6期5卷 487-497页

作者： Roghayeh Baghervand Navid Mehrdad Karimi Morteza Ghojazadeh Seyed Mostafa Araj-Khodaei Alireza Bagherzadeh karimi Sanam Dolati Mehri Bansans Seyed Mohammad Bagher Fazljou Department of Persian Medicine School of Traditional MedicineTabriz University of Medical SciencesTabriz ***Iran Department of iranian Traditional Medicine School of Traditional MedicineTehran University of Medical SciencesTehran ***Iran Research center for Evidence Based Medicine Tabriz University of Medical SciencesTabriz ***Iran Physical Medicine&Rehabilitation Research center Aging Research InstituteTabriz University of Medical SciencesTabriz ***Iran Department of Divinities and Islamic Sciences Faculty of TheologyTabriz UniversityTabriz ***Iran

Delphinium denudatum *** one of the important medicinal herbs of traditional Persian medicine and is known as *** plants are the most widely used drugs in traditional Persian medicine and has been used for various diseases since earlier *** medicinal uses of Delphinium denudatum *** back to over 1,000 years ***(845–925 C.E.)was the first Persian physician and scientist who reported the use of Delphinium denudatum *** a herbal *** the following centuries,the usages of Delphinium denudatum *** the treatment of various diseases has been mentioned in the books and references of traditional Persian medicine for cures to various diseases such as neurologic and psychiatric disease,gastrointestinal disease,fever,pain,and *** to modern studies,the dried roots of Delphinium denudatum *** antipyretic,antimicrobial,anticonvulsant,hepatoprotective,antioxidant,and pain-relieving *** from roots of Delphinium denudatum *** also identified as potential cures for central nervous system diseases as well as for the amelioration of morphine *** denudatum Wall.,with its properties involving the prevention of mitochondrial dysfunction,reduction of oxidative stress,and inflammation and immune dysregulation,can be utilized in curing inflammatory *** effective therapeutic influence of root extract of Delphinium denudatum *** several diseases needs to be confirmed through controlled clinical *** article reviews the different features of Delphinium denudatum *** focuses on the well-known therapeutic effects of this herbal drug on various human disorders and animal disease models.

关键词： Delphinium denudatum Wall. Jadwar root Traditional Persian medicine Neurologic and psychiatric effects Anticonvulsant effects

Reconfiguration of the brain during aesthetic experience on Chinese calligraphy—Using brain complex networks

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Visual Informatics 2022年第1期6卷 35-46页

作者： Rui Li Xiaofei Jia Changle Zhou Junsong Zhang National Engineering Laboratory for Educational Big Data Central China Normal UniversityWuhanHubeiChina Mind Art&Computation GroupDepartment of Artificial IntelligenceSchool of InformaticsXiamen UniversityChina Key Laboratory of Digital Protection and Intelligent Processing of Intangible Cultural Heritage of Fujian and Taiwan Ministry of Culture and TourismChina center for the Study of Brain and Language Qufu Normal UniversityRizhaoChina Faculty of Education The Edmond J.Safra Brain Research Center for the Study of Learning DisabilitiesUniversity of HaifaHaifaIsrael

Chinese calligraphy,as a well-known performing art form,occupies an important role in the intangible cultural heritage of *** studies focused on the psychophysiological benefits of Chinese *** attention has been paid to its aesthetic attributes and effectiveness on the cognitive *** complement our understanding of Chinese calligraphy,this study investigated the aesthetic experience of Chinese cursive-style calligraphy using brain functional network *** stayed on the coach and rested for several ***,they were requested to appreciate artwork of cursive-style *** showed that(1)changes in functional connectivity between frontooccipital,fronto-parietal,bilateral parietal,and central–occipital areas are prominent for calligraphy condition,(2)brain functional network showed an increased normalized cluster coefficient for calligraphy condition in alpha2 and gamma *** results demonstrate that the brain functional network undergoes a dynamic reconfiguration during the aesthetic experience of Chinese *** evidence that the aesthetic experience of Chinese calligraphy has several similarities with western art while retaining its unique characters as an eastern traditional art form.

关键词： Chinese calligraphy Aesthetic experience Electroencephalogram Brain functional connectivity Complex network