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Journal of Clinical and Translational Hepatology 2016年第3期4卷 228-233页

作者： Sayeh Ezzikouri Fatima Zahra Jadid Salsabil Hamdi Lahcen Wakrim Kyoko Tsukiyama-Kohara Soumaya Benjelloun Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc Casablanca Morocco Virology Unit Immunovirology Laboratory Institut Pasteur du Maroc Casablanca Morocco Laboratory of Animal hygiene Joint Faculty of Veterinary MedicineKagoshima University Kagoshima Japan Transboundary Animal Diseases Centre Joint Faculty of Veterinary MedicineKagoshima University Kagoshima Japan

Hepatitis C virus (HCV) infection and type 2 diabetes mellitus (T2DM) present a significant health burden,with increasing complications and mortality rates ***(R) (PYC),a natural product,possesses antidiabetic and antiviral properties that may improve HCV-associated *** this review,we present previously published data on the effectiveness of PYC against HCV replication and *** believe that supplementing conventional treatment with PYC may improve the current HCV therapy,attenuate HCV-associated T2DM,and reduce the risk of complications such as cirrhosis or hepatocellular carcinoma and cardiovascular disease.

关键词： T2DM Hepatitis C Pycnogenol(R) Complementary medicine

Health care-associated hepatitis C virus infection

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World Journal of Gastroenterology 2014年第46期20卷 17265-17278页

作者： Bruno Pozzetto Meriam Memmi Olivier Garraud Xavier Roblin Philippe Berthelot Groupe Immunité des Muqueuses et Agents Pathogènes (GIMAP EA3064) Faculty of Medecine of Saint-EtienneUniversity of Lyon42023 Saint-EtienneFrance Department of Infectious Agents and hygiene University-Hospital of Saint-Etienne42055 Saint-EtienneFrance institut National de la Transfusion Sanguine 75015 ParisFrance Department of Gastroenterology and Hepatology University-Hospital of Saint-Etienne42055 Saint-EtienneFrance Department of Infectious Diseases and hygiene University-Hospital of Saint-Etienne42055 Saint-EtienneFrance

Hepatitis C virus(HCV)is a blood-borne pathogen that has a worldwide distribution and infects millions of ***-associated HCV infections represented a huge part of hepatitis C burden in the past via contaminated blood and unsafe injections and continue to be a serious problem of public *** present review proposes a panorama of health care-associated HCV infections via the three mode of contamination that have been identified:(1)infected patient to non-infected patient;(2)infected patient to non-infected health careworker(HCW);and(3)infected HCW to non infected *** each condition,the circumstances of contamination are described together with the means to prevent *** a whole,the more important risk is represented by unsafe practices regarding injections,notably with the improper use of multidose vials used for multiple *** questions of occupational exposures and infected HCWs are also *** terms of prevention and surveillance,the main arm for combating care-associated HCV infections is the implementation of standard precautions in all the fields of cares,with training programs and audits to verify their good *** must be sensitized to the risk of blood-borne pathogens,notably by the use of safety devices for injections and good hygiene practices in the operating theatre and in all the invasive *** providers performing exposed-prone procedures must monitor their HCV serology regularly in order to detect early any primary infection and to treat it without *** the need to stay vigilant because HCV infection is often a hidden risk,it can be hoped that the number of people infected by HCV via health care will decrease very significantly in the next years.

关键词： Hepatitis C virus Health care-associated infection Health care worker Standard precautions Hemodialysis Unsafe injections Occupational exposure Antiviral drugs

Activation of mitogen activated protein kinases via complement receptor type 2

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Activation of mitogen activated protein kinases via compleme...

Study of Bacteriological and Parasitological Management Quality of Water in the Villages of Senegal

全国新出现传染病学术研讨会

作者：罗敏华 Heribert.Stoiber Manfried.P.Dierich institut fur hygiene Innsbruck UniversitatFritz-Pregl-Str.3A-6010 InnsbruckAustria

Background Complement receptor type 2 (CR2) is the receptor of C3d and C3dg, andEpstein-Barr virus. The aim of our study is to explore if CR2 can mediate the activation of mitogen-activated protein kinases (MAPKs, include ERK, JNK and p38MAPK) independently, and to highlight the molecular mechanism of CD4+ cell deletion in AIDS. Methods CR2 stably expressing HOS cell (HOSCR2) and HOS-CD4 cell (HOS-CD4CR2) were established as previously and identified by FACS and Western Blotting. The activating and blocking test of MAPKs were determined by Western Blotting. Cell proliferation was detected by using Cell Titer 96 Aqueous One Solution Reagent.

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Journal of Biosciences and Medicines 2019年第12期7卷 205-217页

作者： Louis Régis Dossou-Yovo Colette Gomis-Mansaly Isabelle Mady-Goma Dirat Fatoumata Sarr Diene Alioune Badara Ly Ronan Jambou Immunology Clinic and Parasitic Laboratory Institut Pasteur Dakar Senegal Food Security and Environmental hygiene laboratory Institut Pasteur Dakar Senegal Laboratory of Research of Animal Biology and Ecology ENS Marien N’Gouabi University Brazzaville Congo Epidemiology Service Institut Pasteur Dakar Senegal

A survey on the parasitological and bacteriological management was conducted in two villages in southeastern Senegal. The objective of this study was to evaluate the water management modalities in the two villages with ethnic differences and possibly detect factors that could cause waterborne diseases. A questionnaire on water management methods was submitted to one hundred one women drawn in the villages of Dielmo and Ndiop. Samples of well water and water stored in canaries were subjected to both parasitological and bacteriological analysis. In both villages, there was a difference in water management with respect to household configuration (monogamous, polygamous). The containers used for the drawing and storage of water were the same in their two villages. No helminth eggs were found in the drinking water, but bacterial germs, especially faecal coliforms (an indicator of human contamination) and Enterocoques (an indicator of animal contamination). These waters do not comply with WHO standards. So it is important to disinfect them before consumption although no cases of gastroenteritis have been reported.

关键词： Water Management Contamination Helminth Bacteria Dielmo Ndiop Senegal

Human DNA contains sequences homologous to the 5'-non-coding region of hepatitis C virus: characterization with restriction endonucleases reveals individual varieties

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Chinese Medical Journal 2003年第7期116卷 1092-1098页

作者： Reinhard H Dennin Jianer Wo institut für Medizinische Mikrobiologie und hygiene Universitt zu Lübeck Lübeck GermanyInstitute of Infectious Diseases The First Affiliate Hospital College of Medicine Zhejiang University Hangzhou China

Objective To investigate a 272 base pair section of the 5' non coding region of genomic DNA from the peripheral blood monounuclear cells of healthy hepatitis virus C (HCV) negative human subjects (not patients) Mothods This sequence section bears interest because ① it harbors several potential methylation (Cp rich) sites, and ② it represents the largest part of its internal ribosomal entry site A pre PCR digestion protocol was established making consistent use of four restriction endonucleases selected for certain features: SmaI, XmaCI, MspI, and HpaII are inhibited if methylation(s) are present at certain cytosines within their cutting sequences Results The suspected HCV specific sequence was found in the DNA of each subject tested The pre PCR digestion assay reveals individual differences in their pattern of methylation, which may be due to possible epigenetic phenomena Conclusions The results provide formal proof that these HCV specific sequences are contained in the genomic or extra chromosomal target DNA, and probably belong to a new class of endogenous sequences

关键词： HCV sequences · 5' NCR · IRES · human DNA · restriction endonucleases · methylation · epigenetic phenomena

Temporo-spatial dynamics and behavioural patterns of 2012 cholera epidemic in the African mega-city of Conakry,Guinea

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Infectious Diseases of Poverty 2018年第1期7卷 145-154页

作者： Alexandre Blake Veronique Sarr Keita Delphine Sauvageot Mamadou Saliou Berthe Marie Njanpop Fode Sory Bertrand Sudre Koivogui Lamine Martin Mengel Bradford DGessner Keita Sakoba Agence de Medecine Préventive ParisFrance Division Prevention et Lutte contre la Maladie(DPLM) Ministere de la santéPublique et de l’Hygiene Publique ConakryConakryGuinea institut National de Sante Publique(INSP) ConakryGuinea Franche-Comtéuniversity(UMR 6249 chrono-environnement) BesançonFrance.

Background:Cholera is endemic in Guinea,having suffered consecutive outbreaks from 2004 to 2008 followed by a lull until the 2012 *** we describe the temporal-spatial and behavioural characteristics of cholera cases in Conakry during a three-year period,including the large-scale 2012 ***:We used the national and African Cholera Surveillance Network(Africhol)surveillance data collected from every cholera treatment centre in Conakry city from August 2011 to December *** prevalence of suspect and confirmed cholera cases,the case fatality ratio(CFR),and the factors associated with suspected cholera were described according to three periods:pre-epidemic(A),epidemic 2012(B)and post epidemic(C).Weekly attack rates and temporal-spatial clustering were calculated at municipality level for period *** was confirmed by culture at the cholera national reference ***:A total of 4559 suspect cases were reported:66,4437,and 66 suspect cases in periods A,B and C,*** the 204 suspect cases with culture results available,6%,60%,and 70%were confirmed in periods A,B,and C,*** 0.3%,the CFR was significantly lower in period B than in periods A(7.6%)and C(7.1%).The overall attack rate was 0.28%in period B,ranging from 0.17%to 0.31%across ***,a cluster of cases was identified in two districts in the northern part of *** 14%,rice water stools were less frequent in period A than in period B and C(78%and 84%).Dehydration(31%vs 94%and 89%)and coma(0.4%vs 3.1%and 2.9%)were lower during period B than in periods A and *** treatment of drinking water was less frequent in period A,while there were more reports of recent travel in period ***:The epidemic dynamic and the sociological description of suspect cases before,during,and after the large-scale epidemic revealed that the Vibrio cholerae was already present before the ***,it appeared that infected individuals react

关键词： Cholera Space-time clustering Guinea

Coverage of community-wide mass drug administration platforms for soil-transmitted helminths in Benin, India, and Malawi: findings from the DeWorm3 project

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贫困所致传染病(英文) 2024年第5期13卷 16-29页

作者： Means Arianna Rubin ásbj?rnsdóttir Kristjana Hr?nn Sharrock Katherine C. Galagan Sean R. Aruldas Kumudha Avokpaho Euripide Chabi Félicien Halliday Katherine E. Houngbegnon Parfait Israel Gideon John Kaliappan Saravanakumar Puthupalayam Kennedy David Legge Hugo Oswald William E. Palanisamy Gokila Rogers Elliott Timothy Joseph Pearman Emily Ramesh Rohan Michael Simwanza James Sheik-Abdullah Jasmine Farzana Sheikh Mariyam Togbevi Comlanvi Innocent Witek-McManus Stefan Pullan Rachel L. Bailey Robin Kalua Khumbo Ibikounlé Moudachirou Luty Adrian J. F. Ajjampur Sitara S. R. Walson Judd L. Department of Global Health University of Washington Seattle Washington USA The DeWormProject University of Washington Seattle Washington USA Centre of Public Health Sciences University of Iceland Reykjavík Iceland The Wellcome Trust Research Laboratory Division of Gastrointestinal Sciences Christian Medical College Vellore India institut de Recherche Clinique du Bénin Abomey-Calavi Bénin Department of Disease Control Faculty of Infectious and Tropical Diseases London School of Hygiene &amp Tropical Medicine London UK Global Health Division International Development Group Research Triangle Institute (RTI) International Research Triangle Park NC USA Division of Medicine University College London London UK Blantyre institute for Community Outreach Lions Sight First Eye Hospital Blantyre Malawi Department of Population Health Faculty of Epidemiology and Population Health London School of Hygiene &amp Clinical Research Department Faculty of Infectious and Tropical Diseases London School of Hygiene &amp School of Population and Public Health University of British Columbia Vancouver British Columbia Canada Tropical Infectious Diseases Research Center (TIDRC)Université d’Abomey-Calavi Abomey-Calavi Bénin Université Paris Cité Institut de Recherche pour le Développement MERIT Paris F-75006 France Department of International Health Bloomberg School of Public Health Johns Hopkins University Baltimore MD USA

Background Soil-transmitted helminths (STH) affect approximately 1.5 billion people globally. The current STH control strategy is annual or twice-annual preventive chemotherapy, typically school-based deworming targeting children and women of reproductive age. Mathematical modeling suggests that it may be possible to interrupt STH transmission through high-coverage community-wide mass drug administration (cMDA). DeWorm3 is a cluster randomized trial testing cMDA for prevalence reduction and transmission interruption. The purpose of this study is to describe coverage of cMDA in study clusters over time and correlates of coverage at individual and cluster *** From 2018-2020, DeWorm3 delivered six rounds of cMDA with 400 mg albendazole at sites in Benin, India, and Malawi. We report coverage, treatment uptake, and directly observed therapy across all rounds. Factors associated with coverage at the cluster level were identified using binomial generalized estimating equations, while factors associated with non-treatment at the individual level were identified using binomial mixed-effects *** Coverage was high across all clusters and rounds, exceeding the WHO target of 75% in all sites and across all rounds (78% to 95%); cluster-level coverage tended to increase over time. Younger, unmarried, and migratory adults were more likely to be untreated at all sites; adult males were more likely to be untreated in Benin and Malawi. Among children, girls were more likely to be untreated, as were non-school-attending and migratory children. Higher adult education was associated with greater odds of non-treatment among adults, but lower odds among children in the household. Belonging to a less wealthy or minority language-speaking household was associated with non-treatment among both adults and *** It is possible to deliver community-wide MDA with high coverage. Unique individual and community-level factors influence treatment across settings,

关键词： Soil-transmitted helminths Mass drug administration Albendazole Community Coverage

CD2 deficiency partially prevents small bowel inflammation and improves parasite control in murine Toxoplasma gondii infection

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World Journal of Gastroenterology 2007年第31期13卷 4207-4213页

作者： Nina N Pawlowski Daniela Struck Katja Grollich Anja A Kühl Martin Zeitz Oliver Liesenfeld Jrg C Hoffmann Medizinische Klinik I Charité-Universittsmedizin Berlin Campus Benjamin Franklin D12200 Berlin Germany institut für Mikrobiologie und hygiene Charité-Universittsmedizin Berlin Campus Benjamin Franklin D12203 Berlin Germany

To investigate whether bowel inflammation and/or parasite control is altered in the absence of the T cell adhesion molecule CD2.

关键词： CD2 IL-6 Ileitis Inflammatory bowel dis-ease Interferon-T Toxoplasma gondii

Chaotic features of the atmosphere motion near the mesopause revealed by VHF radar observation

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Chinese Science Bulletin 1996年第15期41卷 1276-1280页

作者：熊建刚易帆 J.Klostermeyer R.Rüster Wuhan institute of Physics Chinese Academy of Sciences Wuhan 430071 China Max-Planck-institut

Many observations have revealed the complex motions of the atmosphere because of the rapid developement of experiment technique. However, as compared with numerical stimulations of atmospheric dynamic system, little is known about the complexity occurring in the real atmosphere. The chaotic motion can usually be described by 3 characteristic quantities for the dissipative motion of the atmosphere: dimension, Lyapunov exponent

关键词： VHF radar mesopause atmosphere chaotic features.

Assessment of Anxiety among Caregivers at the Covid-19 Treatment Centers in Grand-Bassam and Cocody-Abidjan from July to September 2020

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Open Journal of Psychiatry 2023年第S1期13卷 410-420页

作者： Etobo Innocent Ahounou Kouadio Raymond N’Guessan Rita Ahou Aka Dion Aristide Gonce Gnonsian Estelle Gahy Yessonguilana Jean-Marie Yeo-Tenena UFR of Medical Sciences Université Félix Houphou&#235t-Boigny Abidjan Ivory Coast Service of Addictology and Mental hygiene Institut National de Santé Publique Abidjan Ivory Coast UFR of Social and Human Sciences University Jean Lorougnon Guédé Daloa Ivory Coast Service of Addictology and Mental hygiene National Institute of Public Health Abidjan Ivory Coast

The rapid spread of coronavirus disease (COVID-19) has led to general psychosis among the population in Ivory Coast. The medical profession, on the front line of the treatment, was in distress, given the risk of exposure to the patient. It is in this context that this study has set itself the objective of studying anxiety among caregivers involved in the management of people with COVID-19. This is a cross-sectional, descriptive and analytical study that included a sample of 50 stakeholders. It took place from July to September 2020 at the Treatment Center of the Village of Information Technologies and Biotechnology in Grand-Bassam (VITIB) and the Infectious Diseases Treatment Center (CTMI) of the University Hospital (CHU) of Cocody. The results indicate that caregivers were male in 52% of cases with an average age of 36 years. These are: doctors, nurses and caregivers respectively in the proportions of 18%, 42% and 40% with more than half (58%) who had more than 5 years of seniority. A proportion of 34% of caregivers felt they were insufficiently protected. The Hamilton Scale assessment of anxiety showed that 14% had mild anxiety, 6% moderate anxiety and 2% severe anxiety. There was no link between the degree of anxiety and professional seniority but also between the degree of anxiety and the marital situation. This work has therefore made it possible to see that anxiety is a real problem for caregivers dedicated to the management of COVID-19 patients.

关键词： COVID-19 Anxiety Assessment Nursing Staff Abidjan