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Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis:A randomized,activecontrol,multicenter clinical trial

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World Journal of Stem Cells 2023年第12期15卷 1063-1076页

作者： Cong-Zi Wu Zhen-Yu Shi Zhen Wu Wen-Jun Lin Wei-Bo Chen Xue-Wen Jia Si-Cheng Xiang Hui-Hui Xu Qin-Wen Ge Kai-Ao Zou Xu Wang Jia-Li Chen Ping-Er Wang Wen-Hua Yuan Hong-Ting Jin Pei-Jian Tong Institute of Orthopaedics and Traumatology of Zhejiang Province The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina epartment of orthopedic surgery The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Orthopaedic surgery Tongde Hospital of Zhejiang ProvinceHangzhou 310012China Department of Orthopaedic surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325015Zhejiang ProvinceChina Department of Orthopaedic surgery Ruian Hospital of Traditional Chinese MedicineWenzhou 325299Zhejiang ProvinceChina Department of Orthopaedics Ningbo First HospitalNingbo 315010Zhejiang ProvinceChina The First College of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Osteoarthritis(OA)is the most prevalent form of degenerative whole-joint *** the final option of knee replacement,arthroscopic surgery was the most widely used joint-preserving surgical *** regenerative therapies,such as those involving platelet-rich plasma,mesenchymal stem cells,and microfragmented adipose tissue(MFAT),have been pushed to the forefront of treatment to prevent the progression of ***,MFAT has been successfully applied to treat different types of orthopedic *** To assess the efficacy and safety of MFAT with arthroscopic surgery in patients with knee OA(KOA).METHODS A randomized,multicenter study was conducted between June 2017 and November 2022 in 10 hospitals in Zhejiang,***,302 patients diagnosed with KOA(Kellgren-Lawrence grades 2-3)were randomized to the MFAT group(n=151,were administered MFAT following arthroscopic surgery),or the control group(n=151,were administered hyaluronic acid following arthroscopic surgery).The study outcomes were changes in the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,the visual analog scale(VAS)score,the Lequesne index score,the Whole-Organ Magnetic Resonance Imaging Score(WORMS),and safety over a 24-mo period from *** The changes in the WOMAC score(including the three subscale scores),VAS pain score,and Lequesne index score at the 24-mo mark were significantly different in the MFAT and control groups,as well as when comparing values at the posttreatment visit and those at baseline(P<0.001).The MFAT group consistently demonstrated significant decreases in the WOMAC pain scores and VAS scores at all follow-ups compared to the control group(P<0.05).Furthermore,the WOMAC stiffness score,WOMAC function score,and Lequesne index score differed significantly between the groups at 12 and 24 mo(P<0.05).However,no signicant between-group differences were observed in the WORMS at 24 mo(P=0.367).No serious adverse events

关键词： Osteoarthritis Microfragmented adipose tissue Lipogems Arthroscopic surgery Knee

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Efficacy and safety of hospital-based group medical quarantine for dialysis patients exposed to coronavirus disease 2019

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Chinese Medical Journal 2022年第19期135卷 2392-2394页

作者： Li Zuo Yu Xu Xinju Zhao Wudong Guo Xiaodan Li Fuyu Qiao Liangying Gan Xiaobo Huang Jie Gao Xiaodong Tang Bo Feng Jiqiu Kuang Yizhang Li Peng Liu Ying Liu Lei Wang Jing Liu Xiaojun Jia Luhua Yang He Zhang Haibo Wang Hongsong Cheng Jianliu Wang Zhancheng Gao Department of Nephrology Peking University People's HospitalBejing 100044China Department of Respiratory and Critical Care Medicine Peking University People's HospitalBeijing 100044China China National Health Development Research Center Bejing 100044China Department of Obstetrics and Gynecology Peking University People's HospitalBejing 100044China xicheng District Center for Disease Prevention and Control Bejing 100120China Urology and Lithotripsy Center Peking University People's HospitalBejing 100044China Department of Hepatobiliary surgery Peking University People's HospitalBeijing 100044China Department of orthopedic Oncology Peking University People's HospitalBeijing 100044China Peking University Hepatology Institute and Bejig Key Laboratory of Hepats C and Immunotherapy for Liver Diseases Peking University People's HospitalBejing 100044China Department of Infection Prevention&Control Peking University People's HospitalBejing 100044China Department of Development Peking Universty People's HospitalBejing 100044China D epartment of Clinical Nutrtin Peking University People's HospitalBejing 100044China Department of Medical Afair Administration Peking Universty People's HospitalBejing 100044China Department of Continuing Medical Education Peking University People's HospitalBejing 100044China Logistics Department Peking Universty People's HospitalBeijing 100044China Administration fice Peking University People's Hospitalejing 100044China Peking University Clnial Research Institute Bejing 100191China.

To the Editor:The coronavirus disease2019(COVID-19)outbreak developedinto a *** hemodialysis(HD)are more susceptible to COVID-19,and isolating patients undergoing HD after exposure are extremely challenging since they frequently travel between their homes and dialysis centers,during which they share a hall for dialysis sessions that may last for *** successfully quarantined one infected HD patient and other potentially exposed *** experience might serve as an important reference for dialysis centers or for people in similar situations across the country to reduce the spread of COVID-19.

关键词： dialysis patients centers

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