Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis:A randomized,activecontrol,multicenter clinical trial
作者机构：Institute of Orthopaedics and Traumatology of Zhejiang ProvinceThe First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina epartment of Orthopedic SurgeryThe First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Orthopaedic SurgeryTongde Hospital of Zhejiang ProvinceHangzhou 310012China Department of Orthopaedic SurgeryThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325015Zhejiang ProvinceChina Department of Orthopaedic SurgeryRuian Hospital of Traditional Chinese MedicineWenzhou 325299Zhejiang ProvinceChina Department of OrthopaedicsNingbo First HospitalNingbo 315010Zhejiang ProvinceChina The First College of Clinical MedicineZhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2023年第15卷第12期
页 面：1063-1076页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：the National Natural Science Foundation of China,No.82274547 the Major Program of the National Natural Science Foundation of Zhejiang Province,No.LD22C060002 the State Administration of Traditional Chinese Medicine of Zhejiang Province,No.GZY-ZJ-KJ-23064 the Zhejiang Provincial Research Foundation for Basic Public Welfare Research,No.LGF20H270005
主 题：Osteoarthritis Microfragmented adipose tissue Lipogems Arthroscopic surgery Knee
摘 要：BACKGROUND Osteoarthritis(OA)is the most prevalent form of degenerative whole-joint *** the final option of knee replacement,arthroscopic surgery was the most widely used joint-preserving surgical *** regenerative therapies,such as those involving platelet-rich plasma,mesenchymal stem cells,and microfragmented adipose tissue(MFAT),have been pushed to the forefront of treatment to prevent the progression of ***,MFAT has been successfully applied to treat different types of orthopedic *** To assess the efficacy and safety of MFAT with arthroscopic surgery in patients with knee OA(KOA).METHODS A randomized,multicenter study was conducted between June 2017 and November 2022 in 10 hospitals in Zhejiang,***,302 patients diagnosed with KOA(Kellgren-Lawrence grades 2-3)were randomized to the MFAT group(n=151,were administered MFAT following arthroscopic surgery),or the control group(n=151,were administered hyaluronic acid following arthroscopic surgery).The study outcomes were changes in the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,the visual analog scale(VAS)score,the Lequesne index score,the Whole-Organ Magnetic Resonance Imaging Score(WORMS),and safety over a 24-mo period from *** The changes in the WOMAC score(including the three subscale scores),VAS pain score,and Lequesne index score at the 24-mo mark were significantly different in the MFAT and control groups,as well as when comparing values at the posttreatment visit and those at baseline(P0.001).The MFAT group consistently demonstrated significant decreases in the WOMAC pain scores and VAS scores at all follow-ups compared to the control group(P0.05).Furthermore,the WOMAC stiffness score,WOMAC function score,and Lequesne index score differed significantly between the groups at 12 and 24 mo(P0.05).However,no signicant between-group differences were observed in the WORMS at 24 mo(P=0.367).No serious adverse events
维普期刊数据库