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A Protocol for Developing Chinese Clinical Practice Guidelines of Hypertension

Cardiology Discovery 2024年第3期4卷 187-191页

作者： Ying Lou Wenjun Ma Zijun Wang Nan Yang Yajia Sun Yunlan Liu Ruobing Lei Junxian Zhao Xufei Luo Lu Wang Yaolong Chen Yaling Han Yingxian Sun Yuming Li Jun Cai Hypertension Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical SciencesBeijing 100037China Evidence-Based Medicine Centre School of Basic Medical SciencesLanzhou UniversityLanzhouGansu 730000China School of Public health Lanzhou UniversityLanzhouGansu 730000China department of Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqing 400014China department of Cardiology General Hospital of Northern Theater CommandShenyangLiaoning 110000China department of Cardiology First Hospital of China Medical UniversityShenyangLiaoning 110000China department of Cardiology TEDA International Cardiovascular HospitalTianjin 300450China.

To improve the standard screening, diagnosis, and treatment of hypertension in patients in China;realize the standardization of clinical practice of hypertension;and improve the prevention and control level of hypertension in China, it is both important and necessary to develop a clinical practice guideline for hypertension according to a recognized methodology. Jointly sponsored by the National Center for Cardiovascular Diseases, Chinese Medical Doctor Association, Hypertension Committee of the Chinese Medical Doctor Association, Chinese Society of Cardiology, and Hypertension Committee of Cross-Straits Medicine Exchange Association, the “Chinese Clinical Practice Guidelines of Hypertension” was proposed. Research Unit of Evidence-Based Evaluation and Guidelines, Chinese Academy of Medical sciences, Guideline and Standards Research Centre of Chinese Medical Association Publishing House, Lanzhou University Institute of health Data Science, and Lanzhou University GRADE Center will provide methodological support for the guidelines.

关键词： Hypertension Clinical practice guidelines Protocol

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Optimized Phishing Detection with Recurrent Neural Network and Whale Optimizer Algorithm

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Computers, Materials & Continua 2024年第9期80卷 4895-4916页

作者： Brij Bhooshan Gupta Akshat Gaurav Razaz Waheeb Attar Varsha Arya Ahmed Alhomoud Kwok Tai Chui department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPuneMaharashtra411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India Ronin Institute MontclairNJ 07043USA Management department College of Business AdministrationPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia department of Business Administration Asia UniversityTaichung413Taiwan department of Electrical and Computer Engineering Lebanese American UniversityBeirut1102Lebanon department of Computer sciences Faculty of Computing and Information TechnologyNorthern Border UniversityRafha91911Saudi Arabia department of Electronic Engineering and Computer Science Hong Kong Metropolitan University(HKMU)HomantinHong KongChina

Phishing attacks present a persistent and evolving threat in the cybersecurity land-scape,necessitating the development of more sophisticated detection *** machine learning approaches to phishing detection have relied heavily on feature engineering and have often fallen short in adapting to the dynamically changing patterns of phishingUniformResource Locator(URLs).Addressing these challenge,we introduce a framework that integrates the sequential data processing strengths of a Recurrent Neural Network(RNN)with the hyperparameter optimization prowess of theWhale Optimization Algorithm(WOA).Ourmodel capitalizes on an extensive Kaggle dataset,featuring over 11,000 URLs,each delineated by 30 *** WOA’s hyperparameter optimization enhances the RNN’s performance,evidenced by a meticulous validation *** results,encapsulated in precision,recall,and F1-score metrics,surpass baseline models,achieving an overall accuracy of 92%.This study not only demonstrates the RNN’s proficiency in learning complex patterns but also underscores the WOA’s effectiveness in refining machine learning models for the critical task of phishing detection.

关键词： Phishing detection Recurrent Neural Network(RNN) Whale Optimization Algorithm(WOA) cybersecurity machine learning optimization

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Performance validation of High Mountain Asia 8-meter Digital Elevation Model using ICESat-2 geolocated photons

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Journal of Mountain Science 2024年第8期21卷 2562-2578页

作者： Giribabu DANDABATHULA Subham ROY Omkar Shashikant GHATAGE Vaibhav Balaso KOLASE Shwetambari SATPUTE Koushik GHOSH Sahibnoor KAUR Satyanarayana PONDARI Apurba Kumar BERA Sushil Kumar SRIVASTAV Regional Remote Sensing Centre-West National Remote Sensing CentreIndian Space Research OrganisationJodhpur 342005India department of Geography School of Earth SciencesBharathidasan UniversityTiruchirappalli 620024India Centre for Climate Change and Water Research Suresh Gyan Vihar UniversityJaipur 302017India department of Geography Panjab UniversityChandigarh 160014India National Remote Sensing Centre Indian Space Research OrganisationHyderabad 500037India Regional Centres National Remote Sensing CentreIndian Space Research OrganisationNew Delhi 110049India

High Mountain Asia(HMA),recognized as a third pole,needs regular and intense studies as it is susceptible to climate *** accurate and high-resolution Digital Elevation Model(DEM)for this region enables us to analyze it in a 3D environment and understand its intricate role as the Water Tower of *** science teams of NASA realized an 8-m DEM using satellite stereo imagery for HMA,termed HMA 8-m *** this research,we assessed the vertical accuracy of HMA 8-m DEM using reference elevations from ICESat-2 geolocated photons at three test sites of varied topography and land *** were made from statistical quantifiers and elevation *** the world’s highest mountain,Mount Everest,and its surroundings,Root Mean Squared Error(RMSE)and Mean Absolute Error(MAE)resulted in 1.94 m and 1.66 m,respectively;however,a uniform positive bias observed in the elevation profiles indicates the seasonal snow cover change will dent the accurate estimation of the elevation in this sort of test *** second test site containing gentle slopes with forest patches has exhibited the Digital Surface Model(DSM)features with RMSE and MAE of 0.58 m and 0.52 m,*** third test site,situated in the Zanda County of the Qinghai-Tibet,is a relatively flat terrain bed,mostly bare earth with sudden river cuts,and has minimal errors with RMSE and MAE of 0.32 m and 0.29 m,respectively,and with a negligible ***,in one more test site,the feasibility of detecting the glacial lakes was tested,which resulted in exhibiting a flat surface over the surface of the lakes,indicating the potential of HMA 8-m DEM for deriving the hydrological *** results accrued in this investigation confirm that the HMA 8-m DEM has the best vertical accuracy and should be of high use for analyzing natural hazards and monitoring glacier surfaces.

关键词： High Mountain Asia Digital Elevation Model ICESat-2 geolocated photons Accuracy assessment

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Female and male visually based mate preferences are consistent with reproductive isolation between populations of the Lake Malawi endemic Labeotropheus fuelleborni

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Current Zoology 2010年第1期56卷 65-72页

作者： Michael J.PAUERS Timothy J.EHLINGER Jeffrey S.McKINNON department of Biological sciences The University of Wisconsin-Milwaukee Division of Natural and health sciences Carroll University department of Biology East Carolina University

Sexual selection via female mate choice is thought to have played a key role in the speciation ofhaplochromine cichlids, but a dominant role for visual signals in such processes has lately been called into question. In addition, the possible role of male mating preferences in haplochromine speciation has been little studied. We studied patterns of both female and male mate choice, based exclusively on visual signals, in order to evaluate potential reproductive isolation between two populations of the Lake Malawi haplochromine Labeotropheus fuelleborni. In the first experiment, females were allowed to choose between two males, one from the same population and the other allopatric with respect to the female. Females in this experiment responded more frequently to males from their own population. Similarly, the males in these trials displayed more frequently when presented with females of their own population. In the second experiment, a female was allowed to choose between two males, either both from her own population or both allopatric. In these trials, both males and females from the Katale population interacted significantly more frequently in settings in which all three individuals were from the same population （＂same-population trios＂）, and those from the Chipoka population showed a similar trend. Thus, patterns in both male and female courtship behavior suggest that visual signals contribute to at least incipient reproductive isolation between populations of L. fuelleborni [Current Zoology 56 （ 1 ）： 65-72 2010].

关键词： Cichlid Mate choice Reproductive isolation Sexual selection Speciation

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Multi-omics analyses of G6PD deficiency variants in Chinese population

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Journal of Genetics and Genomics 2024年第1期51卷 100-104页

作者： He Ji Jiahuan Chen Peide Huang Zhimin Feng Weining Hu Mengyao Dai Xiaohui Sun Xiao Jin Guangquan Chen Guang Ning Lin Li Weiqing Wang Yanan Cao department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesNational Clinical Research Centre for Metabolic DiseasesState Key Laboratory of Medical GenomicsResearch Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical SciencesRuijin Yangtze River Delta Health InstituteWuxi Branch of Ruijin HospitalRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China National Research Center for Translational Medicine National Key Scientific Infrastructure for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China SJTU-BGI Innovation Research Center Shanghai 200240China BGI-ShenZhen ShenzhenGuangdong 518083China

Glucose-6-phosphate dehydrogenase(G6PD)deficiency is one of the most prevalent hereditary and X-linked enzyme disorders caused by the pathogenetic G6PD(NM_001042351.2)variants(Yang et al.,2016).The clinical manifestations of G6PD deficiency offer a wide spectrum of diverse disease phenotypes(Hecker et al.,2013).Investigations of prevalence and molecular epidemiology demonstrate that G6PD deficiency affects over 400 milion individuals worldwide and leads to thousands of deaths annually(Mortality and Causes of Death,2015).

关键词： al. G6PD epidemiology

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Day surgery model: a new path for hospital high-quality development

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Clinical Research Communications 2024年第2期7卷 1-3页

作者： Chao-Liang Tang department of Anesthesiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China.

In the current healthcare system,the day surgery model is increasingly valued and has become an important driving force for the high-quality development of *** day surgery model refers to a medical model where patient... 详细信息

关键词： surgery driving hospital

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Simulating the in vivo tumor microenvironment-advances in building a vascularized model of hepatocellular carcinoma through 3D bioprinting

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 882-884页

作者： Liwei Du Huayu Yang department of Liver Surgery Peking Union Medical College(PUMC)HospitalPUMC&Chinese Academy of Medical Sciences(CAMS)BeijingChina

Over the past decade,there has been notable progress in the systemic treatment of liver ***,despite the emergence of new therapeutic strategies,they have not universally achieved success,with patients afflicted by liver diseases frequently displaying resistance to these treatments(1).Consequently,liver cancer remains a global health challenge,and hepatocellular carcinoma(HCC)stands as the fourth most common cause of cancer-related deaths globally,constituting 80-90%of primary liver cancer cases(2,3).This poses a substantial threat to both the survival and overall well-being of individuals.

关键词： Three-dimensional bioprinting(3D bioprinting) hepatocellular carcinoma(HCC) vascularized model individualized treatment Submitted Mar

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Genetic variation in a heat shock transcription factor modulates cold tolerance in maize

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Molecular Plant 2024年第9期17卷 1423-1438页

作者： Lei Gao Lingling Pan Yiting Shi Rong Zeng Minze Li Zhuoyang Li Xuan Zhang Xiaoming Zhao Xinru Gong Wei Huang Xiaohong Yang Jinsheng Lai Jianru Zuo Zhizhong Gong Xiqing Wang Weiwei Jin Zhaobin Dong Shuhua Yang State Key Laboratory of Plant Environmental Resilience Frontiers Science Center for Molecular Design BreedingCollege of Biological SciencesCenter for Crop Functional Genomics and Molecular BreedingChina Agricultural UniversityBeijing 100193China State Key Laboratory of Maize Bio-breeding National Maize Improvement CenterFrontiers Science Center for Molecular Design BreedingDepartment of Plant Geneticsand BreedingChinaAgricultural UniversityBeijingChina State Key Laboratory of Plant Genomics and National Plant Gene Research Center Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing100101China

Understanding how maize(Zea mays)responds to cold stress is crucial for facilitating breeding programs of cold-tolerant *** extensive utilization of the genome-wide association study(GWAs)approach for exploring favorable natural alleles associated with maize cold tolerance,few studies have successfully identified candidate genes that contribute to maize cold *** this study,we used a diverse panel of inbred maize lines collected from different germplasm sources to perform a GWAS on var-iations in the relative injured area of maize true leaves during cold stress-a trait very closely correlated with maize cold *** identified HsF21,which encodes a B-class heat shock transcription factor(HSF)that positively regulates cold tolerance at both the seedling and germination *** varia-tions in the promoter of the cold-tolerant HSF21Hap1 allele led to increased HSF21 expression under cold stress by inhibiting binding of the basic leucine zipper bziP68 transcription factor,a negative regulator of cold *** integrating transcriptome deep sequencing,DNA affinity purification sequencing,and targeted lipidomic analysis,we revealed the function of HsF21 in regulating lipid metabolism homeo-stasis to modulate cold tolerance in *** addition,we found that HsF21 confers maize cold tolerance without incurring yield ***,this study establishes HsF21 as a key regulator that en-hances cold tolerance in maize,providing valuable genetic resources for breeding of cold-tolerant maize varieties.

关键词： heat shock factor HSF21 cold tolerance natural variation bZiP68 lipid metabolism maize

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Omega-3 in traditional medicine and its role in the treatment of Sickle Cell Disease complications

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Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 76-82页

作者： Tarimoboere Agbalalah Adekunle Babajide Rowaiye department of Anatomy Faculty of Basic Medical SciencesBaze UniversityJabi900108AbujaNigeria department of Medical Biotechnology National Biotechnology Development AgencyLugbe900107AbujaNigeria department of Agricultural Biotechnology National Biotechnology Development AgencyLugbe900107AbujaNigeria

Background:Sickle Cell Disease(SCD)presents a significant global health burden,characterised by inflammation and oxidative stress,contributing to its complex pathophysiology and substantial socioeconomic ***-3 has been shown to alleviate SCD and has been found to be richly available in traditional medicinal plants such as perilla seed,sea buckthorn and ***:This research highlights the potential of omega-3 fatty acid supplementation as a therapeutic intervention for ***:We conducted an extensive search across databases such as PubMed,MEDLINE,and Google Scholar to gather pertinent articles that explore the effect of omega-3 fatty acid on inflammatory and oxidative stress markers in *** such as oxidative stress,and inflammation were also used in the ***-3 fatty acids,particularly EPA and DHA,exhibit anti-inflammatory and antioxidant properties that hold promise in mitigating these pathological ***:Clinical studies demonstrate reductions in pain episodes,hospitalisations,and oxidative stress markers with omega-3 supplementation,indicating its therapeutic ***:Further research is needed to determine optimal dosage,duration,and population-specific *** effectiveness studies and long-term safety assessments are essential for informing clinical *** omega-3 supplementation into comprehensive treatment regimens alongside other modalities may offer a holistic approach to managing ***,ongoing research efforts in omega-3 fatty acid supplementation offer hope for optimizing treatment strategies and improving outcomes for individuals affected by SCD.

关键词： Omega-3 fatty acid Sickle cell disease Oxidative stress Inflammation Supplementation

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Effects of fentanyl and sucrose on pain in retinopathy examinations with pain scale,near-infrared spectroscopy,and ultrasonography:a randomized trial

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World Journal of Pediatrics 2023年第9期19卷 873-882页

作者： Nursu Kara Didem Arman Zeynep Seymen Adem Gül Serdar Cömert department of Pediatrics Division of NeonatologyUniversity of Health Sciences Istanbul Research and Training HospitalIstanbulTurkey department of Opthalmology University of Health Sciences Istanbul Research and Training HospitalIstanbulTurkey

Background This study aimed to compare the efficacy of intravenous,intranasal fentanyl and oral sucrose in reducing the pain response during retinopathy of prematurity examinations using premature infant pain profile(PIPP)*** The study included 42 infants who underwent retinopathy screening *** infants were divided into three groups:oral sucrose,intranasal fentanyl,and intravenous *** signs(heart rate,arterial oxygen saturation,and mean arterial pressure)were *** PIPP was used to determine pain *** oxygenation and middle cerebral artery blood flow were evaluated using near-infrared spectroscopy and Doppler ultrasonography,*** data obtained were compared between *** There was no significant difference between the three groups regarding postconceptional and postnatal ages or birth weights and weight at the time of *** babies had moderate pain during the *** correlation was observed between analgesia method and pain scores(P=0.159).In all three groups,heart rate and mean arterial pressure increased,whereas oxygen saturation decreased during the exam compared with pre-examination ***,heart rate(HR),mean arterial pressure(MAP)and arterial oxygen saturation(sPO2)values did not differ between groups(HR,P=0.150;MAP,P=0.245;sPO2,P=0.140).The cerebral oxygenation(rSO2)values between the three groups were found to be similar[rSO2:P=0.545,P=0.247,P=0.803;fractional tissue oxygen extraction(FTOE):P=0.553,P=0.278].Regarding cerebral blood flow values,we also did not find any difference between the three groups[mean blood flow velocity(Vmean):P=0.569,P=0.975;maximum flow velocity(Vmax):P=0.820,P=0.997].Conclusions Intravenous and intranasal fentanyl and oral sucrose were not superior to each other in preventing pain during the examination for retinopathy of prematurity(ROP).Sucrose may be a good alternative for pain control during ROP *** findings suggest

关键词： Analgesia Cerebral blood flow Cerebral oxygenation Neonate Retinopathy of prematurity

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