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Major Clinical Features and Epidemic Characteristics of Erosive Vulvar Lichen Planus:A Retrospective Analysis

International Journal of Dermatology and Venereology 2024年第2期7卷 94-98页

作者： Ya-Kun Shao Kai-Lyu Sun Min Yang Wan Liu Yu Fu Jian-Min Chang department of Dermatology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective:Vulvar lichen planus(VLP),especially erosive VLP(EVLP),seriously affects women’s physiological function and quality of life.A retrospective analysis of erosive vulvar lichen planus(EVLP)was performed to raise awareness on this chronic,deforming,and painful vulvar ***:This observational retrospective study involved 40 patients with EVLP among 1,368 patients with vulvar disease from 2017 to *** patients’vulvar clinical features and extravulvar mucosal involvement were *** patients’pain and quality of life were evaluated with the numeric rating scale and the Dermatology Life Quality Index(DLQI),*** characteristics were reported using frequencies and proportions for categorical *** variables are expressed as mean±standard *** association between NRS score for pain and DLQI score was analyzed by Pearson’s correlation ***:EVLP accounted for 2.9%(40/1,368)of all cases of vulvar disease,and the median age at onset was 42 *** mostly occurred on the labia minora and ***(20/40)of the patients had extravulvar mucosal ***(42.5%)patients had oral lichen planus,and seven(17.5%)patients were diagnosed with vulvovaginal-gingival *** numeric rating scale score showed that 47.5%(19/40)of patients experienced mild pain,whereas 12.5%(5/40)described the pain as ***-one patients(77.5%,31/40)had dyspareunia,and nine patients had aggravated pain after sexual *** mean DLQI score was 9.1±6.0,with 37.5%(15/40)of patients indicating that EVLP had severely affected their *** numeric rating scale score for pain was significantly correlated with the DLQI score(P=0.007).Conclusion:EVLP can affect the quality of women’s lives and cause severe deformations and painful architectural *** description of the characteristics of EVLP in this report will benefit the diagnosis and early treatment of this disease.

关键词： erosive vulvar lichen planus multiple mucosal involvement pain assessment quality of life Dermatology Life Quality Index numeric rating scale

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Challenging anticoagulation therapy for multiple primary malignant tumors combined with thrombosis:A case report and review of literature

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World Journal of Clinical Cases 2024年第9期12卷 1704-1711页

作者： Jia-Xin Chen Ling-Ling Xu Jing-Ping Cheng Xun-Hua Xu department of gerontology China Resources and Wisco General HospitalWuhan University of Science and TechnologyWuhan 430080Hubei ProvinceChina Medical College Wuhan University of Science and TechnologyWuhan 430065Hubei ProvinceChina department of gerontology China Resources and Wisco General HospitalWuhan 430080Hubei ProvinceChina department of Radiology China Resources and Wisco General HospitalWuhan 430080Hubei ProvinceChina

BACKGROUND Venous thromboembolism significantly contributes to patient deterioration and *** of its etiology and anticoagulation treatment is intricate,necessitating a comprehensive consideration of various factors,including the bleeding risk,dosage,specific anticoagulant medications,and duration of ***,a case of lower extremity thrombosis with multiple primary malignant tumors and high risk of bleeding was reviewed to summarize the shortcomings of treatment and prudent anticoagulation *** SUMMARY An 83-year-old female patient was admitted to the hospital due to a 2-wk history of left lower extremity edema that had worsened over 2 *** her medical history and relevant post-admission investigations,it was determined that the development of left lower extremity venous thrombosis and pulmonary embolism in this case could be attributed to a combination of factors,including multiple primary malignant tumors,iliac venous compression syndrome,previous novel coronavirus infection,and inadequate treatment for prior thrombotic ***,the selection of appropriate anticoagulant medications,determination of optimal drug dosages,and establishment of an appropriate duration of anticoagulation therapy were important because of concurrent thrombocytopenia,decreased quantitative fibrinogen levels,and renal *** Anticoagulant prophylaxis should be promptly initiated in cases of high-risk *** anticoagulation therapy is required for complex thrombosis.

关键词： Venous thromboembolism Cancer-associated thrombosis Anticoagulation therapy iliac vein compression syndrome COVID-19 Thrombocytopenia Case report

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Microdeletion on Xq27.1 in a Chinese VACTERL-Like Family with Kidney and Anal Anomalies

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Biomedical and Environmental Sciences 2024年第5期37卷 503-510页

作者： LI Min ZHANG Yu Lan ZHANG Kai Li LI Ping Ping LYU Yu Han LIANG Ya Xin YU Yue department of Gynecology and Obstetrics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing HospitalBeijing 100730China The Key Laboratory of Geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective VATER/VACTERL-like association is associated with adverse pregnancy *** evidence of this disorder is *** this study,we aimed to provide genetic insights to improve the diagnosis of *** We have described a Chinese family in which four members were affected by renal defects or agenesis,anal atresia,and anovaginal fistula,which is consistent with the diagnosis of a VACTERL-like *** and genetic analyses were conducted using genome and exome *** Segregation analysis revealed the presence of a recessive X-linked microdeletion in two living affected individuals,harboring a 196–380 kb microdeletion on Xq27.1,which was identified by familial exome *** sequencing was performed on the affected male,confirming a-196 kb microdeletion in Xq27.1,which included a 28%loss of the CDR-1 *** family members were included in the co-segregation analysis,and only VACTERL-like cases with microdeletions were reported in *** These results suggest that the 196–380 kb microdeletion in Xq27.1 could be a possible cause of the VATER/VACTERL-like ***,further genetic and functional analyses are required to confirm or rule out genetic background as the definitive cause of the VACTERL association.

关键词： Prenatal diagnosis VACTERL whole-genome sequencing whole-exome sequencing X-linked

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Clinical and molecular significance of homologous recombination deficiency positive non-small cell lung cancer in Chinese population:An integrated genomic and transcriptional analysis

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Chinese Journal of Cancer Research 2024年第3期36卷 282-297页

作者： Yifei Wang Yidan Ma Lei He Jun Du Xiaoguang Li Peng Jiao Xiaonan Wu Xiaomao Xu Wei Zhou Li Yang Jing Di Changbin Zhu Liming Xu Tianlin Sun Lin Li Dongge Liu Zheng Wang department of Pathology department of Minimally Invasive Tumor Therapies Center department of Thoracic Surgery department of Oncology department of Respiratory and Critical Care Medicine Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Amoy Diagnostics Co. Ltd.Xiamen 361027China

Objective:The clinical significance of homologous recombination deficiency(HRD)in breast cancer,ovarian cancer,and prostate cancer has been established,but the value of HRD in non-small cell lung cancer(NSCLC)has not been fully *** study aimed to systematically analyze the HRD status of untreated NSCLC and its relationship with patient prognosis to further guide clinical ***:A total of 355 treatment-naïve NSCLC patients were retrospectively *** status was assessed using the AmoyDx Genomic Scar Score(GSS),with a score of≥50 considered ***,transcriptomic,tumor microenvironmental characteristics and prognosis between HRD-positive and HRDnegative patients were ***:Of the patients,25.1%(89/355)were *** to HRD-negative patients,HRDpositive patients had more somatic pathogenic homologous recombination repair(HRR)mutations,higher tumor mutation burden(TMB)(P<0.001),and fewer driver gene mutations(P<0.001).Furthermore,HRD-positive NSCLC had more amplifications in PI3K pathway and cell cycle genes,MET and MYC in epidermal growth factor receptor(EGFR)/anaplastic lymphoma kinase(ALK)mutant NSCLC,and more PIK3CA and AURKA in EGFR/ALK wild-type ***-positive NSCLC displayed higher tumor proliferation and immunosuppression ***-negative NSCLC showed activated signatures of major histocompatibility complex(MHC)-II,interferon(IFN)-γand effector memory CD8+T ***-positive patients had a worse prognosis and shorter progressionfree survival(PFS)to targeted therapy(first-and third-generation EGFR-TKIs)(P=0.042).Additionally,HRDpositive,EGFR/ALK wild-type patients showed a numerically lower response to platinum-free immunotherapy ***:Unique genomic and transcriptional characteristics were found in HRD-positive *** prognosis and poor response to EGFR-TKIs and immunotherapy were observed in HRD-positive *** study highlights potential actionable alterations in HRD

关键词： Non-small cell lung cancer homologous recombination deficiency genetic alterations transcriptional analysis tumor microenvironment prognosis

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Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu Hori Daisuke Mizutani Tomoyuki Hioki Kumi Kojima Takashi Onuma Yukiko Enomoto Tomoaki Doi Rie Matsushima-Nishiwaki Shinji Ogura Hiroki Iida Toru Iwama Takashi Sakurai Osamu Kozawa department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGROUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

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Malnutrition and Its Association with the Mortality of Patients with Femoral Intertrochanteric Fractures: A Retrospective Analysis of Japanese Patients

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Open Journal of Orthopedics 2024年第1期14卷 22-31页

作者： Taizo Kaneko Kyoko Matsudaira Kentaro Hayakawa Fumiaki Tokimura Tsuyoshi Miyazaki department of Orthopaedic Surgery Tokyo Metropolitan Institute for Geriatrics and Gerontology Tokyo Japan

Background: The incidence of femoral intertrochanteric fractures in older adults is higher than that of femoral neck fractures;however, both conditions are often analyzed together as proximal femoral fractures. Considering the difference in treatment, postoperative complication, and mortality risk, these two fractures should be analyzed separately. This study aimed to analyze 1-year mortality and its risk factors in patients with surgically treated femoral intertrochanteric fractures. Methods: Consecutive patients with intertrochanteric fractures who underwent surgical interventions at our institution between January 2017 and December 2021 were retrospectively reviewed. A total of 238 patients were eligible for inclusion in this study. Patients’ demographic and clinical information were retrospectively collected. Patients were divided into the 1-year mortality (n = 16) and survival (n = 222) groups. The incidence of 1-year mortality and its independent risk factors were investigated using univariate and multivariate logistic regression analyses. Results: The mean age of patients was 85.6 ± 8.5 years. The 1-year mortality rate was 6.7% (16/238). Preoperative albumin level, the Geriatric Nutritional Risk Index (GNRI), and malnutrition status (GNRI p = 0.02, p = 0.02, and p = 0.0011, respectively). Multivariate analysis showed that malnutrition status (GNRI p = 0.035) was an independent risk factor for 1-year mortality. Conclusion: Malnutrition status assessed using GNRI (GNRI < 92) was an independent risk factor for 1-year mortality. Our findings suggest that GNRI may be an effective screening tool for predicting postoperative 1-year mortality of patients with surgically treated femoral intertrochanteric fractures.

关键词： Intertrochanteric Fracture Mortality Geriatric Nutritional Risk Index Malnutrition Risk Factor

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Cardiovascular risk burden and disability:findings from the International Mobility in Aging Study(IMIAS)

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Journal of Geriatric Cardiology 2024年第3期21卷 331-339页

作者： Juan-David Martinez-Aristizábal Carmen-Lucia Curcio Juliana Fernandes Afshin Vafael Cristiano dos Santos Gomes Fernando Gomez Internal Medicine Critical Care DepartmentPablo Tobón Uribe HospitalMedellínColombia Research Group in Geriatrics and gerontology Faculty of Health SciencesUniversidad de CaldasManizalesColombia Laboratory of Physical Therapy and Collective Health Physical Therapy DepartmentFederal University of PernambucoJornalista Aníbal Fernandes Avenue RecifeBrazil department of Public Health Sciences Queen’s UniversityKingstonONCanada department of Physiotherapy University of PernambucoBR 203KmBrazil

BACKGROUND The association of cardiovascular risk burden with disability is *** examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCRS)with the trajectories of limitations of physical function in older *** A total of 1219 participants with no disabilities from the International Mobility in Aging Study(IMIAS)study who had up to three repeated measures of FGCRS between 2012–2016 and without a history of stroke or coronary heart disease at baseline and follow-up were *** at baseline was assessed and categorized into *** function was evaluated with the Short Physical Performance Battery(SPPB).The data were analyzed using linear mixed-effects *** At baseline,FGCRS ranged between 3–94(mean score:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lowest,middle,and highest tertiles,*** the trajectories of limitations of physical function,the lowest FGCRS had no differences,while the middle and highest had a decrease in physical performance between 2012–2014(P=0.0001).Age,being female,living in Andes Mountains,having middle and highest FGCRS,higher alcohol consumption,being obese,lack of exercise and cognitive impairment increase the probability of disability(P<0.05).Alternatively,living in more developed regions and having a higher educational level reduced the probability of disability during the follow-up time(P<0.05).CONCLUSIONS Higher cardiovascular risk burden is associated with decreased physical performance,especially in *** suggest SPPB may provide a measure of cardiovascular health in older adults.

关键词： finding Battery burden

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Exogenous insulin autoimmune syndrome:A case report and review of literature

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World Journal of Clinical Cases 2024年第9期12卷 1691-1697页

作者： Ling-Ling Xu Jia-Xin Chen Jing-Ping Cheng Ni Luo Medical College School of MedicineWuhan University of Science and TechnologyWuhan 430065Hubei ProvinceChina department of gerontology CR&WISCO General Hospital Affiliated to Wuhan University of Science and TechnologyWuhan 430080Hubei ProvinceChina

BACKGROUND Insulin autoimmune syndrome(IAS)is a severe manifestation of spontaneous *** is characterized by elevated levels of immune-reactive insulin and highly potent insulin autoantibodies(IAAs),which are induced by endogenous insulin circulating in the *** is distinguished by recurring instances of spontaneous hypoglycemia,the presence of IAA within the body,a substantial elevation in serum insulin levels,and an absence of prior exogenous insulin ***,recent studies show that both conventional insulin and its analogs can induce IAS episodes,giving rise to the notion of nonclassical ***,more attention should be paid to these *** SUMMARY In this case report,we present a rare case of non-classical IAS in an 83-year-old male patient who present with symptoms of a psychiatric *** symptom onset,the patient exhibited Whipple's triad(including hypoglycemia,blood glucose level less than 2.8 mmol/L during onset,and rapid relief of hypoglycemic symptoms after glucose administration).Concurrently,his serum insulin level was significantly elevated,which contradicted his C-peptide *** a comprehensive examination,the patient was diagnosed with exogenous insulin autoimmune *** that the patient had type 2 diabetes mellitus and a history of exogenous insulin use before disease onset,it was presumed that non classical IAS was induced by this *** PubMed database was used to search for previous cases of IAS and non-classical IAS to analyze their characteristics and treatment *** The occurrence of non-classical IAS is associated with exogenous insulin or its analogs,as well as with sulfhydryl *** can be effectively alleviated through the discontinuation of relevant medications,administration of hormones or immunosuppressants,plasma exchange,and lifestyle adjustments.

关键词： Insulin autoimmune syndrome Type 2 diabetes Exogenous insulin Insulin autoantibodies Hypoglycemia Case report

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Microglia in brain aging:An overview of recent basic science and clinical research developments

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Journal of Biomedical Research 2024年第2期38卷 122-136页

作者： Haixia Fan Minheng Zhang Jie Wen Shengyuan Wang Minghao Yuan Houchao Sun Liu Shu Xu Yang Yinshuang Pu Zhiyou Cai Chongqing Medical University Chongqing 400042China department of Neurology Chongqing General HospitalChongqing 400013China Chongqing Key Laboratory of Neurodegenerative Diseases Chongqing 400013China department of Neurology the First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China department of gerontology the First People's Hospital of JinzhongJinzhongShanxi 030009China

Aging is characterized by progressive degeneration of tissues and organs,and it is positively associated with an increased mortality *** brain,as one of the most significantly affected organs,experiences age-related changes,including abnormal neuronal activity,dysfunctional calcium homeostasis,dysregulated mitochondrial function,and increased levels of reactive oxygen *** changes collectively contribute to cognitive *** is also a key risk factor for neurodegenerative diseases,such as Alzheimer's disease and Parkinson's *** many years,neurodegenerative disease investigations have primarily focused on neurons,with less attention given to microglial ***,recently,microglial homeostasis has emerged as an important mediator in neurological disease ***,we provide an overview of brain aging from the perspective of the *** doing so,we present the current knowledge on the correlation between brain aging and the microglia,summarize recent progress of investigations about the microglia in normal aging,Alzheimer's disease,Parkinson's disease,Huntington's disease,and amyotrophic lateral sclerosis,and then discuss the correlation between the senescent microglia and the brain,which will culminate with a presentation of the molecular complexity involved in the microglia in brain aging with suggestions for healthy aging.

关键词： microglia brain aging Alzheimer's disease Parkinson's disease Huntington's disease

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Updated prevalence of latent prostate cancer in Chinese population and comparison of biopsy results: An autopsy-based study

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The Innovation 2024年第1期5卷 80-87页

作者： Yuliang Chen Zhien Zhou Yi Zhou Zhipeng Mai Shijie Jin Zhen Liang Zhiyuan Shang Yuzhi Zuo Yu Xiao Wenze Wang Haibo Wang Weigang Yan department of Urology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China department of Gynaecology and Obstetrics Beijing HospitalNational Centre of GerontologyBeijing 100730China department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Peking University Clinical Research Institute Peking University First HospitalBeijing 100034China

Prostate cancer detected by autopsy is named latent prostate *** the repertoire of clinical prostate cancer,latent cancer may better reflect the disease *** clinical prostate specimens,which are obtained exclusively from biopsy-positive cases,prostate specimens obtained through autopsy provide information on biopsy-negative cases,helping calculate the true sensitivity of prostate *** 2014 to 2021,we collected autopsy specimens of the prostate from body donors in China and performed transperineal and transrectal biopsies on specimens before step-sectioning and pathological *** found that the crude prevalence of latent prostate cancer in middle-aged and elderly men was 35.1%(81/231),which was higher than previous estimates for Chinese *** overall per-patient sensitivities of transperineal and transrectal biopsies were not significantly different(33.3%vs.32.1%,p=0.82),but the two approaches differed in preferential sampling area along the proximal-distal axis of the *** biopsy had a higher sensitivity for detecting clinically significant lesions in the distal third(34.7%vs.16.3%,p=0.02)and distal half(30.6%vs.18.1%,p=0.04),while transrectal biopsy had a higher sensitivity for lesions in the proximal half(25.0%vs.13.9%,p=0.046).Both transperineal and transrectal methods of biopsy missed most small lesions(0.5 mL).In conclusion,the prevalence of latent prostate cancer in China has increased over the past 2 *** transperineal and transrectal methods of biopsy had comparable sensitivities but had different preferential sampling *** approaches miss one-third of large lesions.

关键词： biopsy prevalence latent

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