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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina center for Cognitive and brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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Distinct neuron populations for simple and compound calls in the primary auditory cortex of awake marmosets

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National Science Review 2021年第11期8卷 92-101页

作者： Huan-huan Zeng Jun-feng Huang Jun-ru Li Zhiming Shen Neng Gong Yun-qing Wen Liping Wang Mu-ming Poo center for Excellence in brain Science and Intelligence Technology Institute of NeuroscienceState Key Laboratory of Neuroscience CAS Key Laboratory of Primate NeurobiologyChinese Academy of Sciences Shanghai center for brain Science and brain-Inspired Intelligence Technology University of Chinese Academy of Sciences

Marmosets are highly social non-human primates that live in families. They exhibit rich vocalization, but the neural basis underlying this complex vocal communication is largely unknown. Here we report the existence of specific neuron populations in marmoset A1 that respond selectively to distinct simple or compound calls made by conspecific marmosets. These neurons were spatially dispersed within A1 but distinct from those responsive to pure tones. Call-selective responses were markedly diminished when individual domains of the call were deleted or the domain sequence was altered, indicating the importance of the global rather than local spectral-temporal properties of the sound. Compound call-selective responses also disappeared when the sequence of the two simple-call components was reversed or their interval was extended beyond 1 s. Light anesthesia largely abolished call-selective responses. Our findings demonstrate extensive inhibitory and facilitatory interactions among call-evoked responses, and provide the basis for further study of circuit mechanisms underlying vocal communication in awake non-human primates.

关键词： marmoset calls calcium imaging awake marmosets primary auditory cortex vocal communication

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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Intracerebroventricularly-administered 1-methyl-4-phenylpyridinium ion and brain-derived neurotrophic factor affect catecholaminergic nerve terminals and neurogenesis in the hippocampus,striatum and substantia nigra

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Neural Regeneration Research 2018年第4期13卷 717-726页

作者： Jun-Fang Chen Man Wang Ying-Han Zhuang Thomas Behnisch The Institutes of brain Science the State Key Laboratory of Medical Neurobiologyand the Collaborative Innovation Center for Brain ScienceFudan University

Parkinson＇s disease is a progressive neurological disease characterized by the degeneration of dopaminergic neurons in the substantia nigra.A highly similar pattern of neurodegeneration can be induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine（MPTP） or 1-methyl-4-phenylpyridinium ion（MPP＋）,which cause the death of dopaminergic *** of MPTP or MPP＋ results in Parkinson＇s disease-like symptoms in ***,it remains unclear whether intracerebroventricular MPP＋ administration affects neurogenesis in the substantia nigra and subgranular zone or whether brain-derived neurotrophic factor alters the effects of MPP＋.In this study,MPP＋（100 nmol） was intracerebroventricularly injected into mice to model Parkinson＇s *** 7 days after administration,the number of bromodeoxyuridine（Brd U）-positive cells in the subgranular zone of the hippocampal dentate gyrus increased,indicating enhanced *** contrast,a reduction in Brd U-positive cells was detected in the substantia *** of brain-derived neurotrophic factor（100 ng） 1 day after MPP＋ administration attenuated the effect of MPP＋ in the subgranular zone and the substantia *** findings reveal the complex interaction between neurotrophic factors and neurotoxins in the Parkinsonian model that result in distinct effects on the catecholaminergic system and on neurogenesis in different brain regions.

关键词： nerve regeneration Parkinson's disease MPTP brain-derived neurotrophic factor intracerebroventricular infusion dopaminergic fibers norepinephrine tyrosine hydroxylase hippocampus substantia nigra striatum neurogenesis neural regeneration

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Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham Christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

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Drug-and cell-based therapies for targeting neuroinflammation in traumatic brain injury

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Neural Regeneration Research 2016年第10期11卷 1575-1576页

作者： Sussannah Kaelber Paolina Pantcheva Cesar V.Borlongan center of Excellence for Aging and brain Repair Department of Neurosurgery and Brain Repair University of South Florida College of Medicine

TBI pathology： Traumatic brain injury （TBI） is caused by an external force to the head, resulting in trauma to the brain. Approximately 1.7 million Americans suffer from TBI every year. Out of the 1.7 million suffering from TBI, an estimated 52,000 injuries result in death, leaving a mass amount of peo- ple with symptoms that could last a few days, a few years, or their entire life （Faul et al., 2010）. TBI can be classified as mild, moderate and severe. Depending on the classification and the extent of the injury, TBI can cause both physical symptoms and cognitive disorders （Lozano et al., 2015）.

关键词： TBI cell Drug-and cell-based therapies for targeting neuroinflammation in traumatic brain injury

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Enhancing endogenous stem cells in the newborn via delayed umbilical cord clamping

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Neural Regeneration Research 2015年第9期10卷 1359-1362页

作者： Christopher Lawton Sandra Acosta Nate Watson Chiara Gonzales-Portillo Theo Diamandis Naoki Tajiri Yuji Kaneko Paul R.Sanberg Cesar V.Borlongan center of Excellence for Aging and brain Repair Department of Neurosurgery and Brain Repair University of South Florida College of Medicine

There is currently no consensus among clinicians and scientists over the appropriate or optimal timing for umbilical cord clamping. However, many clinical studies have suggested that delayed cord clamping is associated with various neonatal benefits including increased blood volume, reduced need for blood transfusion, increased cerebral oxygenation in pre-term infants, and decreased frequency of iron deficiency anemia in term infants. Human umbilical cord blood con- tains significant amounts of stem and progenitor cells and is currently used in the treatment of several life-threatening diseases. We propose that delayed cord clamping be encouraged as it en- hances blood flow from the placenta to the neonate, which is accompanied by an increase supply of valuable stem and progenitor cells, as well as may improve blood oxygenation and increase blood volume, altogether reducing the infant＇s susceptibility to both neonatal and age-related diseases.

关键词： stem cells umbilical cord blood neonates regenerative medicine

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Geometry Flow-Based Deep Riemannian Metric Learning

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IEEE/CAA Journal of Automatica Sinica 2023年第9期10卷 1882-1892页

作者： Yangyang Li Chaoqun Fei Chuanqing Wang Hongming Shan Ruqian Lu Key Lab of MADIS Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China IEEE Institute of Science and Technology for brain-Inspired Intelligence and Key Laboratory of Computational Neuroscience and brain-Inspired Intelligence(Ministry of Education)and MOE Frontiers center for brain Science Fudan UniversityShanghai 200433 Shanghai center for brain Science and brain-Inspired Technology Shanghai 200031China

Deep metric learning(DML)has achieved great results on visual understanding tasks by seamlessly integrating conventional metric learning with deep neural *** deep metric learning methods focus on designing pair-based distance loss to decrease intra-class distance while increasing interclass ***,these methods fail to preserve the geometric structure of data in the embedding space,which leads to the spatial structure shift across mini-batches and may slow down the convergence of embedding *** alleviate these issues,by assuming that the input data is embedded in a lower-dimensional sub-manifold,we propose a novel deep Riemannian metric learning(DRML)framework that exploits the non-Euclidean geometric structural *** that the curvature information of data measures how much the Riemannian(nonEuclidean)metric deviates from the Euclidean metric,we leverage geometry flow,which is called a geometric evolution equation,to characterize the relation between the Riemannian metric and its *** DRML not only regularizes the local neighborhoods connection of the embeddings at the hidden layer but also adapts the embeddings to preserve the geometric structure of the *** several benchmark datasets,the proposed DRML outperforms all existing methods and these results demonstrate its effectiveness.

关键词： Curvature regularization deep metric learning(DML) embedding learning geometry flow riemannian metric

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Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults

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Neuroscience Bulletin 2014年第2期30卷 172-184页

作者： Jing Yu Tao Su Ting Zhou Yingge He Jing Lu Juan Li Rongqiao He center on ageing Psychology Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Faculty of Psychology Southwest University State Key Laboratory of brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences The University of Chinese Academy of Sciences

Recent studies have shown that the abnormal accumulation of endogenous formaldehyde could be a critical factor in age-related cognitive decline. The aim of this study was to estimate the correlation between uric formaldehyde and general cognitive abilities in a community-based elderly population, and to measure the extent and direction in which the correlation varied with demographic characteristics. Using a double-blind design, formaldehyde in human urine was analyzed by high-performance liquid chromatography （n = 604）, and general cognitive abilities were measured using the Montreal Cognitive Assessment （MoCA）. Demographic characteristics, in terms of age, gender, residential region, and education were taken into consideration. We found that uric formaldehyde levels were inversely correlated with the MoCA score, and the concentration varied with demographic features： higher odds of a high formaldehyde level occurred among the less educated and those living in old urban or rural areas. In cytological experiments, the level of cellular formaldehyde released into the medium increased as SH-SY5Y and BV2 cells were incubated for three days. Formaldehyde in excess impairedthe processes of N2a cells and neurites of primary cultured rat hippocampal cells. However, removal of formaldehyde markedly rescued and regenerated the processes of N2a cells. These results demonstrated a negative correlation between the endogenous formaldehyde and general cognitive abilities. High formaldehyde levels could be a risk factor for cognitive impairment in older adults, and could be developed as a non-invasive marker for detection and monitoring of age-related cognitive impairment.

关键词： uric formaldehyde the MontrealCognitive Assessment education learning livingregion

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Guan-hua Xu:China's move toward being a country of innovation

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National Science Review 2015年第2期2卷 237-240页

作者： Mu-ming Poo Ling Wang CAS center for Excellence in brain Science NSR

As the former Minister of China’s Ministry of Science&Technology(MoST),Guan-hua Xu has witnessed,and personally contributed to,China’s science and technology(S&T)development during the critical period of the country’s transition into a great economic *** his tenure at MoST and its predecessor(1995–2007),he promoted the reform of research institutions,initiated some of the Nation’s most

关键词： Guan-hua Xu

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