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Mechanomedicine:From Mechanogenomics to Mechano-Immunoengineering

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医用生物力学 2024年第S1期 5-6页

作者： Song Li department of bioengineering and Medicine University of California

Mechanobiology is a rapidly growing field that has expanded significantly over the past 40 years. There have been great examples of mechanobiology research on the cardiovascular, musculoskeletal, and respiratory systems. The field has evolved from the system level to the organ and tissue levels, and down to the cellular and molecular levels, benefiting from scientific progress and technological developments in molecular and cell biology, biomaterials, imaging techniques, and computational tools. Additionally, the interdisciplinary integration of mechanobiology with cell engineering, tissue engineering, and drug delivery has led to promising mechanomedicine applications in both therapeutics and ***, I will discuss two examples at the molecular and cellular levels:(1) mechanical regulation of epigenomics for cell reprogramming, and (2) engineering the mechanical properties of artificial antigen-presenting cells (APCs) for immune cell modulation and cancer *** memory of its identity is determined by the epigenetic state of the cells. However, how cells control the epigenetic state and thus cell fate is not well understood, and how mechanical factors such as surface topography, cell morphology,mechanical properties of the extracellular matrix (ECM), and the mechanical deformation of cells regulate the epigenetic state is not clear. In an early study, we showed that biophysical cues, in the form of parallel microgrooves on the surface of cell-adhesive substrates, can replace the effects of small-molecule epigenetic modifiers and significantly improve reprogramming efficiency from fibroblasts to induced pluripotent stem cells. The mechanism relies on the mechanomodulation of the cells’ epigenetic state through the activity of histone deacetylase and H3 methyltransferase. We also showed that microtopography promotes a mesenchymal-to-epithelial transition in adult fibroblasts. Nanofibrous scaffolds with aligned fiber orientation produce effects similar

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Crosstalk between Wnt and bone morphogenetic protein signaling during osteogenic differentiati

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World Journal of Stem Cells 2024年第2期16卷 102-113页

作者： Pakkath Narayanan Arya Iyyappan Saranya Nagarajan Selvamurugan department of Biotechnology School of BioengineeringSRM Institute of Science and TechnologyKattankulathur 603203India

Mesenchymal stem cells(MSCs)originate from many sources,including the bone marrow and adipose tissue,and differentiate into various cell types,such as osteoblasts and *** studies on MSCs have revealed that many transcription factors and signaling pathways control osteogenic *** is the process by which new bones are formed;it also aids in bone ***/β-catenin and bone morphogenetic protein(BMP)signaling pathways are involved in many cellular processes and considered to be essential for ***/β-catenin and BMPs are important for bone formation in mammalian development and various regulatory activities in the *** studies have indicated that these two signaling pathways contribute to osteogenic *** Wnt signaling pathway promotes osteogenesis by activating the downstream targets of the BMP signaling ***,we briefly review the molecular processes underlying the crosstalk between these two pathways and explain their participation in osteogenic differentiation,emphasizing the canonical *** review also discusses the crosstalk mechanisms of Wnt/BMP signaling with Notch-and extracellular-regulated kinases in osteogenic differentiation and bone development.

关键词： Bone Mesenchymal stem cells Osteogenic differentiation Wnt/β-catenin Bone morphogenetic proteins

Magnesium-incorporated biocomposite scaffolds:A novel frontier in bone tissue engineering

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Journal of Magnesium and Alloys 2024年第6期12卷 2231-2248页

作者： Abinaya Shanmugavadivu Sundaravadhanan Lekhavadhani Sushma Babu Nivetha Suresh Nagarajan Selvamurugan department of Biotechnology School of BioengineeringCollege of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia

Nonunion represents a crucial challenge in orthopedic medicine,demanding innovative solutions beyond the scope of traditional bone grafting *** the various strategies available,magnesium(Mg)implants have been recognized for their biocompatibility and ***,their susceptibility to rapid corrosion and degradation has garnered notable research interest in bone tissue engineering(BTE),particularly in the development of Mg-incorporated biocomposite *** scaffolds gradually release Mg2+,which enhances immunomodulation,osteogenesis,and angiogenesis,thus facilitating effective bone *** review presents myriad fabrication techniques used to create Mg-incorporated biocomposite scaffolds,including electrospinning,three-dimensional printing,and sol-gel *** these advancements,the application of Mg-incorporated biocomposite scaffolds faces challenges such as controlling the degradation rate of Mg and ensuring mechanical *** limitations highlight the necessity for ongoing research aimed at refining fabrication techniques to better regulate the physicochemical and osteogenic properties of *** review provides insights into the potential of Mg-incorporated biocomposite scaffolds for BTE and the challenges that need to be addressed for their successful translation into clinical applications.

关键词： Magnesium Bone tissue engineering Immunomodulation Osteogenesis Angiogenesis

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Stretchable fiber strain sensors for wearable biomonitoring

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National Science Review 2024年第07期 70-71页

作者： Shumao Xu Xiao Xiao Jun Chen department of bioengineering University of California

Wearable bioelectronics have gained significant attention since they may play a role in transforming current healthcare from a reactive and disease-centric model to a personalized one with a focus on disease preventio...

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In vitro engineered models of neurodegenerative diseases

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BIOCELL 2024年第1期48卷 79-96页

作者： ZEHRA GÜL MORÇIMEN ŞEYMA TAŞDEMIR AYLIN ŞENDEMIR bioengineering department Graduate School of Natural and Applied SciencesEge UniversityIzmir35040Türkiye bioengineering department Faculty of Engineering and Natural ScienceCelal Bayar UniversityManisa45110Türkiye bioengineering department Ege UniversityIzmir35040Türkiye department of Biomedical Technologies Graduate School of Natural and Applied SciencesEge UniversityIzmir35040Türkiye

Neurodegeneration is a catastrophic process that develops progressive damage leading to functional andstructural loss of the cells of the nervous system and is among the biggest unavoidable problems of our *** do not reflect the pathophysiology observed in humans due to distinct differences between the neuralpathways,gene expression patterns,neuronal plasticity,and other disease-related mechanisms in animals *** in vitro cell culture models are also not sufficient for pre-clinical drug testing in reflecting thecomplex pathophysiology of neurodegenerative ***,modern,engineered techniques are applied to developmulticellular,intricate in vitro models and to create the closest microenvironment simulating biological,biochemical,and mechanical characteristics of the in vivo degenerating *** THIS review,the capabilities and shortcomings ofscaffold-based and scaffold-free techniques,organoids,and microfluidic models that best reflect neurodegeneration invitro in the biomimetic framework are discussed.

关键词： Neurodegenerative diseases In vitro models Scaffolds Organoids Microfluidic devices

Small activating RNA delivery in vivo:Challenges,prospects,and lessons learned from siRNA delivery

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Nano Research 2024年第10期17卷 8990-9002页

作者： Shalini Pandey Patrick T.Bednarz Matthias A.Oberli Omid Veiseh department of bioengineering William Marsh Rice UniversityHouston 77030USA Xibus Systems 199 Dexter AveWatertown 02472USA

Over the last two decades,small activating RNAs(saRNAs)have quickly moved from discovery to clinical *** as 20 nucleotide long,double stranded RNA,saRNAs have the unique ability to increase gene transcription at the chromatin *** therapeutic modality has great potential as a safe and redosable alternative to gene therapy by increasing target protein expression without changing the genetic *** describe the successful in vivo saRNA delivery vectors and found that similar to small interfering RNA(siRNA)and mRNA targeting tissues outside the liver works best at the end of a *** highlight nanoparticle vectors and RNA-conjugates,where some success has been reported for non-hepatic delivery of saRNAaptamers.

关键词： small activating RNA hepatic bias lipid nanoparticles RNA-conjugates

Adaptive multi-channel Bayesian graph attention network for IoT transaction security

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Digital Communications and Networks 2024年第3期10卷 631-644页

作者： Zhaowei Liu Dong Yang Shenqiang Wang Hang Su School of Computer and Control Engineering Yantai UniversityYantai264005China department of Electronics Information and BioengineeringPolitecnico di MilanoMilan20133Italy

With the rapid advancement of 5G technology,the Internet of Things(IoT)has entered a new phase of appli-cations and is rapidly becoming a significant force in promoting economic *** to the vast amounts of data created by numerous 5G IoT devices,the Ethereum platform has become a tool for the storage and sharing of IoT device data,thanks to its open and tamper-resistant ***,Ethereum account security is necessary for the Internet of Things to grow quickly and improve people's *** modeling Ethereum trans-action records as a transaction network,the account types are well identified by the Ethereum account classifi-cation system established based on Graph Neural Networks(GNNs).This work first investigates the Ethereum transaction ***,experimental metrics reveal that the Ethereum transaction network is neither optimal nor even satisfactory in terms of accurately representing transactions per *** flaw may significantly impede the classification capability of GNNs,which is mostly governed by their *** work proposes an Adaptive Multi-channel Bayesian Graph Attention Network(AMBGAT)for Ethereum account clas-sification to address this *** uses attention to enhance node features,estimate graph topology that conforms to the ground truth,and efficiently extract node features pertinent to downstream *** extensive experiment with actual Ethereum transaction data demonstrates that AMBGAT obtains competitive performance in the classification of Ethereum accounts while accurately estimating the graph topology.

关键词： Internet of things Graph representation learning Node classification Security mechanism

Bioinspired nanomaterials for wearable sensing and human–machine interfacing

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Nano Research 2024年第2期17卷 445-461页

作者： Vishesh Kashyap Junyi Yin Xiao Xiao Jun Chen department of bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA

The inculcation of bioinspiration in sensing and human–machine interface(HMI)technologies can lead to distinctive characteristics such as conformability,low power consumption,high sensitivity,and unique properties like self-healing,self-cleaning,and *** sensing and HMI are fields rife with opportunities for the application of bioinspired nanomaterials,particularly when it comes to wearable sensory systems where biocompatibility is an additional *** review discusses recent development in bioinspired nanomaterials for wearable sensing and HMIs,with a specific focus on state-of-the-art bioinspired capacitive sensors,piezoresistive sensors,piezoelectric sensors,triboelectric sensors,magnetoelastic sensors,and electrochemical *** also present a comprehensive overview of the challenges that have hindered the scientific advancement in academia and commercialization in the industry.

关键词： bioinspired nanomaterials human–machine interface wearable sensors wearable bioelectronics

Ionic liquid-based transparent membrane-coupled human lung epithelium-on-a-chip demonstrating PM0.5 pollution effect under breathing mechanostress

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Bio-Design and Manufacturing 2024年第5期7卷 624-636页

作者： Bilgesu Kaya Ozlem Yesil-Celiktas department of bioengineering Faculty of EngineeringEge UniversityIzmir 35100Türkiye Translational Pulmonary Research Center(EgeSAM) Ege UniversityIzmir 35100Türkiye

The plausibility of human exposure to particulate matter(PM)has witnessed an increase within the last several *** of different sizes has been discovered in the atmosphere given the role of dust transport in weather and climate *** a regulator,the lung epithelium orchestrates the innate response to local ***,we developed a lung epithelium-ona-chip platform consisting of easily moldable polydimethylsiloxane layers along with a thin,flexible,and transparent ionic liquid-based poly(hydroxyethyl)methacrylate gel *** epithelium was formed through the culture of human lung epithelial cells(Calu-3)on this *** mechanical stress at the air–liquid interface during inhalation/exhalation was recapitulated using an Arduino-based servo motor system,which applied a uniaxial tensile strength from the two sides of the chip with 10%strain and a frequency of 0.2 ***,the administration of silica nanoparticles(PM0.5)with an average size of 463 nm to the on-chip platform under static,dynamic,and dynamic+mechanical stress(DMS)conditions demonstrated the effect of environmental pollutants on lung *** viability and release of lactate dehydrogenase were determined along with proinflammatory response through the quantification of tumor necrosis factor-α,which indicated alterations in the epithelium.

关键词： Ionic liquid-based membrane Lung Epithelial barrier Mechanostress Organ-on-chip Silica particles

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