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Dysregulation of neurogenesis by neuroinflammation:key differences in neurodevelopmental and neurological disorders

Neural Regeneration Research 2017年第3期12卷 366-371页

作者： Lir-Wan Fan Yi Pang ackson MSUSA

Embryonic neurogenesis is the process of generating neurons,the functional units of the *** of its sensitivity to adverse intrauterine environment such as infection,dysregulation of this process has emerged as a key mechanism underlying many neurodevelopmental disorders such as autism spectrum disorders（ASD）.Adult neurogenesis,although is restricted to a few neurogenic niches,plays pivotal roles in brain plasticity and *** evidence suggests that impairments in adult neurogenesis are involved in major neurodegenerative disorders such as Alzheimer＇s disease.A hallmark feature of these brain disorders is neuroinflammation,which can either promote or inhibit neurogenesis depending upon the context of brain *** this review paper,we present evidence from both experimental and human studies to show a complex picture of relationship between these two events,and discussed potential factors contributing to different or even opposing actions of neuroinflammation on neurogenesis in neurodevelopmental and neurological disorders.

关键词： microglia neurodegeneration autism embryonic neurogenesis adult neurogenesis cytokine aging

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Strategies for myelin regeneration: lessons learned from development

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Neural Regeneration Research 2014年第14期9卷 1347-1350页

作者： Abhay Bhatt Lir-Wan Fan Yi Pang Department of Pediatrics Division of Newborn MedicineUniversity of Mississippi Medical CenteracksonMSUSA

Myelin regeneration is indispensably important for patients suffering from several central nervous system （CNS） disorders such as multiple sclerosis （MS） and spinal cord injury （SCI）, because it is not only essential for restoring neurophysiology, but also protects denuded axons for secondary degeneration. Understanding the cellular and molecular mechanisms underlying remyelination is critical for the development of remyelination-specific therapeutic approaches. As remyelination shares certain common mechanisms with developmental myelination, knowledge from study of developmental myelination contributes greatly to emerging myelin regeneration therapies, best evidenced as the recently developed human anti-Nogo receptor interacting protein-1 （LINGO-1） monoclonal antibodies to treat MS patients in clinical trials.

关键词： oligodendrocyte myelination microglia multiple sclerosis white matter damage spinalcord injury

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