Dysregulation of neurogenesis by neuroinflammation:key differences in neurodevelopmental and neurological disorders

作     者：Lir-Wan Fan Yi Pang 

作者机构：acksonMSUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2017年第12卷第3期

页      面：366-371页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by grants from NIH(R01NS080844)(LWF) Michael J.Fox foundation(YP) Intramural Research Support Program(YP) the Department of Pediatrics,University of Mississippi Medical Center 

主　　题：microglia neurodegeneration autism embryonic neurogenesis adult neurogenesis cytokine aging 

摘      要：Embryonic neurogenesis is the process of generating neurons,the functional units of the *** of its sensitivity to adverse intrauterine environment such as infection,dysregulation of this process has emerged as a key mechanism underlying many neurodevelopmental disorders such as autism spectrum disorders（ASD）.Adult neurogenesis,although is restricted to a few neurogenic niches,plays pivotal roles in brain plasticity and *** evidence suggests that impairments in adult neurogenesis are involved in major neurodegenerative disorders such as Alzheimer＇s disease.A hallmark feature of these brain disorders is neuroinflammation,which can either promote or inhibit neurogenesis depending upon the context of brain *** this review paper,we present evidence from both experimental and human studies to show a complex picture of relationship between these two events,and discussed potential factors contributing to different or even opposing actions of neuroinflammation on neurogenesis in neurodevelopmental and neurological disorders.