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Breeding phase and outcome determine space use in European rollers Coracias garrulus prior to migration

Current Zoology 2024年第2期70卷 137-149页

作者： Flavio Monti Sanja Barisic Sebastian Cannarella Davor Cikovic Vesna Tutis JelenaKralj Carlo Catoni auniversity of siena Department of Physical SciencesEarth and EnvironmentVia Mattioli 453100 SienaItaly Institute of Ornithology Croatian Academy of Sciences and ArtsGunduliceva 24HR-1000 ZagrebCroatia Ornis italica Piazza Crati 1500199 RomeItaly

The breeding period is a demanding and time-constrained phase for migratory bird *** outcome and duration can interact with the extent and duration of post-breeding movements,resulting in individual differences in space use ultimately influencing later stages of the annual *** present space-use and home range estimates during the breeding season for 21 European rollers Coracias garrulus tracked between 2018 and 2022,in Italy and *** high-resolution spatial GPS data coupled with regular nest-box monitoring,we analyzed dif-ferences in space use during the incubation/nestling period versus post-breeding period prior to migration,accounting for the breeding outcome(successful ***).We found that adult movements were strongly reduced during the first phase,whereas increased in the post-breeding phase,especially for failed *** breeders remained in the surroundings of the nest site,whereas unsuccessful ones tended to abandon the nest and visit distant areas(up to 500 km)for long periods(60.5±6.2 days).Breeding outcome did not influence the departure date of autumn migration,suggesting that failed breeders used this period for exploratory movements but not for advancing the onset of *** exploratory movements may be functional to prospect and inform settlement decisions in failed breeders in search of new breeding opportunities and may be particularly important in migratory species,which generally have a limited period to gather information prior to autumn *** study demonstrates the need to investigate seasonal movements in different populations and the potential importance of pros-pectingpost-breeding movements for long-distance migratory species.

关键词： animal movement biologging conservation Coracidae Mediterranean nest-box population monitoring prospecting movements reproduction.

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Themis releases the brakes on TCR signaling during thymocyte selection by disabling SHP-1

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Cellular & Molecular Immunology 2017年第9期14卷 724-726页

作者： Laura Patrussi Cosima T Baldari Department of Life Sciences University of SienaSiena 53100Italy

In this issue of Nature Immunology,Choi and colleagues1 identify a key function of the T cell-specific protein thymocyte-expressed molecule involved in selection(THEMIS)in T cell *** demonstrate that the two structural CABIT(cysteine-containing all beta in THEMIS)modules contained in this protein are able to directly bind to the phosphotyrosine-phosphatase(PTP)domain of SHP-1(Src homology region 2 domain-containing phosphatase-1)and inhibit its phosphatase activity by increasing the susceptibility of its catalytic site to oxidation.

关键词： development. release susceptibility

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Competitor densities,habitat,and weather:effects on interspecific interactions between wild deer species

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Integrative Zoology 2021年第5期16卷 670-684页

作者： Francesco FERRETTI NiccolòFATTORINI Research Unit of Behavioural Ecology Ethology and Wildlife ManagementDepartment of Life SciencesUniversity of SienaSienaItaly

There is a growing interest on the potential interplay between weather,habitat,and interspecific competition on population dynamics of wild *** environmental conditions may buffer the negative effects of competition;conversely,competition may be expected to be stronger under harsh environmental *** investigated relationships between competitor abundance,weather,and habitat cover on density and local distribution of a medium-sized herbivore,the roe deer Capreolus capreolus,as well as its spatial overlap with fallow deer Dama dama in a Mediterranean protected *** 11 years(2007–2017),roe deer density was not affected by spring–summer rainfall in the previous year and decreased with increasing density of fallow deer in the previous ***,over the considered temporal scale,results supported a major role of competition over weather in influencing population trends of roe *** a finer spatial scale,roe deer occupancy was negatively affected by local abundance of fallow deer,especially in“poorer”*** found a slight support for a positive effect of fallow deer density on interspecific spatial ***,fine-scale spatial overlap between deer species increased with decreasing rainfall in spring–*** deer were introduced to our study area in historical times and their role as superior competitors over roe deer has been found also in other study *** suggest a potential role of harsh weather conditions during the growing season of vegetation(*** rainfall)in triggering the potential for ecological overlap,emphasizing the negative effects of interspecific competition.

关键词： interspecific competition deer niche partitioning rainfall ungulates Dama dama Capreolus capreolus

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Magnetic resonance imaging:Is there a role in clinical management for acute ischemic colitis?

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World Journal of Gastroenterology 2013年第8期19卷 1256-1263页

作者： Maria Antonietta Mazzei Susanna Guerrini Nevada Cioffi Squitieri Giusi Imbriaco Raffaele Chieca Serenella Civitelli Vinno Savelli Francesco Giuseppe Mazzei Luca Volterrani Department of Human Pathology and Oncology Section of Radiological SciencesUniversity of Siena53100 SienaItaly Oncologic Department UOC Gastroenterology and Digestive EndoscopyAzienda Ospedaliera Universitaria Senese53100 SienaItaly Division of Surgery Azienda Ospedaliera Universitaria SeneseUniversity of Siena53100 SienaItaly Department of Surgery and Bioengineering Section of SurgeryUniversity of Siena53100 SienaItaly Department of Diagnostic Imaging Azienda Ospedaliera Universitaria Senese53100 SienaItaly

AIM:To validate the utility of magnetic resonance imaging(MRI) for the clinical management of acute ischemic colitis(IC).METHODS:This is a magnetic resonance(MR) prospective evaluation of 7 patients who were proved to have acute IC on the basis of clinical,endoscopic and computed tomography(CT) findings and who were imaged in our institution between February 2011 and July *** mean age of the patients was 72.28 *** CTs were obtained using a 64-detector row configuration for all patients with un-enhanced and contrast-enhanced scans,in the late arterial phase(start delay 45-50 s) and in the portal venous phase(start delay 70-80 s).The MR examinations were performed using a 1.5T superconducting magnet,using Fast Imaging Employing Steady State Acquisition and T2-weighted fast-recovery fast-spin echo sequences in axial and coronal *** and MRI examinations were analysed for the presence of colonic abnormalities and associated ***:Segmental involvement was seen in 6 patients(85.71%),with a mean length of involvement of 412 mm(range 145.5-1000 mm).Wall thickness varied between 6 mm and 17.5 mm(mean 10.52 mm) upon CT examinations and from 5 to 15 mm(mean 8.8 mm) upon MR *** MRI appearance of the colonic wall varied over the time:TypeⅠappearance with a 3 layer sandwich sign was seen in 5 out of 12 examinations(41.66%),patients underwent MR within a mean of 36 h(ranging from 1 to 54 h) after the CT *** Ⅱ and Ⅲ appearance with a 2 layer sign,was seen in 4 examinations(33.33%),patients underwent MR within a mean of 420.5 h(ranging from 121 to 720 h) after the CT *** the remaining three MRI examinations,performed within a mean of 410 h(ranging from 99.5 to 720 h) the colonic wall appeared ***:MRI,only using precontrast images,may be used as a substitute for invasive procedures in diagnosis and follow-up of acute IC.

关键词： Ischemic colitis Magnetic resonance imaging Medical management Colon Computed tomography

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Variable selection-based SPC procedures for high-dimensional multistage processes

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Journal of Systems Engineering and Electronics 2019年第1期30卷 144-153页

作者： KIM Sangahn Department of Business Analytics and Acturial Science Siena College

Monitoring high-dimensional multistage processes becomes crucial to ensure the quality of the final product in modern industry environments. Few statistical process monitoring(SPC) approaches for monitoring and controlling quality in highdimensional multistage processes are studied. We propose a deviance residual-based multivariate exponentially weighted moving average(MEWMA) control chart with a variable selection procedure. We demonstrate that it outperforms the existing multivariate SPC charts in terms of out-of-control average run length(ARL) for the detection of process mean shift.

关键词： diagnosis procedure deviance residual fault identification model-based control chart multistage process monitoring variable selection.

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Organelle trafficking, the cytoskeleton, and pollen tube growth

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Journal of Integrative Plant Biology 2015年第1期57卷 63-78页

作者： Giampiero Cai Luigi Parrotta Mauro Cresti Department of Life Sciences University of Siena

The pollen tube is fundamental for the reproduction of seed plants. Characteristically, it grows relatively quickly and uni-directionally （＂polarized growth＂） to extend the male gametophyte to reach the female gametophyte. The pollen tube forms a channel through which the sperm cells move so that they can reach their targets in the ovule. To grow quickly and directionally, the pollen tube requires an intense movement of organelles and vesicles that allows the cell＇s contents to be distributed to sustain the growth rate. While the various organelles distribute more or less uniformly within the pollen tube, Golgi-released secretory vesicles accumulate massively at the pollen tube apex, that is, the growing region. This intense movement of organelles and vesicles is dependent on the dynamics of the cytoskeleton, which reorganizes differentially in response to external signals and coordinates membrane trafficking with the growth rate of pollen tubes.

关键词： Actin filaments cytoplasmic streaming microtubules motor proteins tip growth

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Study of cytoskeleton from microscopic point of view:Our experience

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BIOCELL 2022年第4期46卷 881-884页

作者： CINZIA SIGNORINI GIULIA COLLODEL ELENA MORETTI Department of Molecular and Developmental Medicine of University of siena SienaI-53100Italy

The manuscript deals with our studies and experiences in the assessment of cytoskeleton in different cellular models and *** immunofluorescent study of several cytoskeletal proteins was relevant in the evaluation of a therapy for osteoarthritis,in case of alkaptonuria and in testing the efficacy of docetaxel in neuroblastoma cancer cells leading to apoptosis.A relevant part of our experience focus on the study of cytoskeleton in seminiferous epithelium and spermatozoa,identifying alterations affecting blood-testis barrier after a silver nanoparticle treatment,chromosomal segregation in case of varicocele,sperm motility and diagnosing systematic sperm defects as“Primary ciliary dyskinesia”and“Dysplasia of the fibrous sheath”.The evaluation of cytoskeleton represents a specific and sensitive analysis in establishing the health status of different cells.

关键词： cytoskeleton Environment Immunocytochemistry Pathological condition

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Liquid biopsy and blood-based minimal residual disease evaluation in multiple myeloma

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Oncology Research 2023年第3期31卷 271-274页

作者： ALESSANDRO GOZZETTI MONICA BOCCHIA Division of Hematology University of SienaAzienda Ospedaliera UniversitariaSiena53100Italy

Novel drug availability has increased the depth of response and revolutionised the outcomes of multiple myeloma *** residual disease evaluation is a surrogate for progression-free survival and overall survival and has become widely used not-only in clinical trials but also in daily patient *** marrow aspiration is the gold standard for response evaluation,but due to the patchy nature of myeloma,false negatives are *** biopsy and blood-based minimal residual disease evaluation consider circulating plasma cells,mass spectrometry or circulating tumour *** approach is less invasive,can provide a more comprehensive picture of the disease and could become the future of response evaluation in multiple myeloma patients.

关键词： Myeloma Liquid biopsy Minimal residual disease

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How to conjugate the stemness marker ALDH1A1 with tumor angiogenesis,progression,and drug resistance

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Cancer Drug Resistance 2020年第1期3卷 26-37页

作者： Valerio Ciccone Lucia Morbidelli Marina Ziche Sandra Donnini Department of Life Sciences University of SienaSiena 53100Italy Department of Medicine Surgery and NeuroscienceUniversity of SienaSiena 53100Italy

Cancer is the second leading cause of death *** survival of cancer patients depends on the efficacy of therapies and the development of *** are many mechanisms involved in the acquisition of drug resistance by cancer cells,including the acquisition of stem-like *** stem cells(CSCs)represent a major source of tumor progression and treatment *** are a subpopulation of cancer cells having the abilities to self-renew and form spheres in *** dehydrogenase 1A1(ALDH1A1)is a cytosolic enzyme involved in the detoxification of cells from toxic aldehydes and belongs to the ALDH *** ALDH1A1 activity is closely related to stemness phenotype of several tumors,possibly contributing to cancer progression and diffusion in the *** have documented the contribution of ALDH1A1 in tumor angiogenesis in breast cancer cells by the activation of hypoxia inducible factor-1αand vascular endothelial growth factor *** review discusses the involvement of ALDH1A1 in the development of different hallmarks of cancer to propose it as a novel putative target for cancer treatment to achieve better ***,we analyze the involvement of ALDH1A1 in the acquisition of stemness phenotype in tumor cells,the regulation of tumor angiogenesis and metastases,and the acquisition of anticancer drug resistance and immune evasion.

关键词： Aldehyde dehydrogenase 1A1 angiogenesis drug resistance immune editing metastases stemness

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Medieval Towns, Traffic and Urban Planning Half a Century since the First Pedestrian Zone in siena, Italy

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Journal of Traffic and Transportation Engineering 2016年第2期4卷 107-115页

作者： Stefano Maggi Department of Political and lnternational Science University of Siena Siena 1-53100 Italy

The Italian town is known as a collection of wails, gates, towers, palaces and cathedrals. The lanes and the squares were created in the Middle Ages, with an urban fabric suitable for horses and carriages, not for motor cars. At the beginning of the 1960s, it was no longer possible to delay a solution to the problem of traffic and the first ＂pedestrian isle＂ was realized in the centre of siena in 1965. Other towns in a few years followed this virtuous example. Acts against traffic avoided the building of urban motorways and the demolition of ancient buildings that would have given the ＂coup de grace＂ to several important historic centres.

关键词： Medieval town urban environment traffic and urban planning transport history.

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