Themis releases the brakes on TCR signaling during thymocyte selection by disabling SHP-1

作     者：Laura Patrussi Cosima T Baldari 

作者机构：Department of Life SciencesUniversity of SienaSiena 53100Italy 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2017年第14卷第9期

页      面：724-726页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 070802[理学-空间物理学] 07[理学] 0708[理学-地球物理学] 

主　　题：development. release susceptibility 

摘      要：In this issue of Nature Immunology,Choi and colleagues1 identify a key function of the T cell-specific protein thymocyte-expressed molecule involved in selection(THEMIS)in T cell *** demonstrate that the two structural CABIT(cysteine-containing all beta in THEMIS)modules contained in this protein are able to directly bind to the phosphotyrosine-phosphatase(PTP)domain of SHP-1(Src homology region 2 domain-containing phosphatase-1)and inhibit its phosphatase activity by increasing the susceptibility of its catalytic site to oxidation.