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International Journal of Oral Science 2021年第2期13卷 117-128页

作者： Sevda Pouraghaei Sevari Sahar Ansari Alireza Moshaverinia Weintraub Center for Reconstructive Biotechnology Division of Advanced ProsthodonticsSchool of DentistryUniversity of CaliforniaLos AngelesLos AngelesCAUSA california NanoSystems Institute University of CaliforniaLos AngelesLos AngelesCAUSA

Tissue engineering approaches have emerged recently to circumvent many limitations associated with current clinical *** elegant approach utilizes a natural/synthetic biomaterial with optimized physiomechanical properties to serve as a vehicle for delivery of exogenous stem cells and bioactive factors or induce local recruitment of endogenous cells for in situ tissue *** by the natural microenvironment,biomaterials could act as a biomimetic three-dimensional(3D)structure to help the cells establish their natural *** a strategy should not only employ a biocompatible biomaterial to induce new tissue formation but also benefit from an easily accessible and abundant source of stem cells with potent tissue regenerative *** human teeth and oral cavity harbor various populations of mesenchymal stem cells(MSCs)with self-renewing and multilineage differentiation *** the current review article,we seek to highlight recent progress and future opportunities in dental MSC-mediated therapeutic strategies for tissue regeneration using two possible approaches,cell transplantation and cell ***,this paper develops a general picture of current innovative strategies to employ dental-derived MSCs combined with biomaterials and bioactive factors for regenerating the lost or defective tissues and offers information regarding the available scientific data and possible applications.

关键词： biomaterials utilizing utilize

在绵羊模型中比较羟基磷灰石涂层与亲水表面对牙科种植体早期愈合的影响

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在绵羊模型中比较羟基磷灰石涂层与亲水表面对牙科种植体早期愈合...

Therapeutic effect of bone marrow mesenchymal stem cells on cold stress induced changes in the hippocampus of rats

第九次全国口腔材料学术交流会

作者： Jin Whan Lee 温海波 Jeffrey Bassett 曹俊贞 Zimmer dental Inc. 1900 Aston AvenueCarlsbadCA 92008USA

目的:水热处理后的等离子喷涂羟基磷灰石(HA)涂层已被用于牙科种植体,以提高其生物相容性和骨结合性能。与氧化铝喷砂和酸蚀处理的种植体相比,HA涂层种植体愈合更快,并且骨-种植体的接触百分比更高(%BIC)。文献证实,与表面无涂层的种植... 详细信息

目的:水热处理后的等离子喷涂羟基磷灰石(HA)涂层已被用于牙科种植体,以提高其生物相容性和骨结合性能。与氧化铝喷砂和酸蚀处理的种植体相比,HA涂层种植体愈合更快,并且骨-种植体的接触百分比更高(%BIC)。文献证实,与表面无涂层的种植体相比,HA涂层还具有显著较高的存活率。与机械加工表面相比,粗糙表面能更快实现骨结

关键词：牙科种植体羟基磷灰石涂层材料亲水表面早期愈合效果

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Neural Regeneration Research 2014年第19期9卷 1740-1744页

作者： Saravana Kumar Sampath Kumar Saraswathi Perumal Vijayaraghavan Rajagopalan Department of Anatomy Saveetha Dental College Saveetha University ChennaiTamil NaduIndia

The present study aims to evaluate the effect of bone marrow mesenchymal stem cells on cold stress induced neuronal changes in hippocampal ca1 region of Wistar rats. Bone marrow mes- enchymal stem cells were isolated from a 6-week-old Wistar rat. Bone marrow from adult femora and tibia was collected and mesenchymal stem cells were cultured in minimal essential medium containing 10% heat-inactivated fetal bovine serum and were sub-cultured. Passage 3 cells were analyzed by flow cytometry for positive expression of CD44 and CD90 and negative expression of CD45. Once CD44 and CD90 positive expression was achieved, the cells were cultured again to 90% confluence for later experiments. Twenty-four rats aged 8 weeks old were randomly and evenly divided into normal control, cold water swim stress （cold stress）, cold stress ＋ PBS （intra- venous infusion）, and cold stress ＋ bone marrow mesenchymal stem cells （1 x 106; intravenous infusion） groups. The total period of study was 60 days which included 1 month stress period followed by 1 month treatment. Behavioral functional test was performed during the entire study period. After treatment, rats were sacrificed for histological studies. Treatment with bone marrow mesenchymal stem cells significantly increased the number of neuronal cells in hippocampal ca 1 region. Adult bone marrow mesenchymal stem cells injected by intravenous administration show potential therapeutic effects in cognitive decline associated with stress-related lesions.

关键词： nerve regeneration bone marrow mesenchymal stem cells hippocampus cold stress intravenous cognition neuronal cells ca1 region neural regeneration

High-purity Mg and Mg-1ca alloys:Comparative assessment of the merits regarding degradation,osteogenesis,and biosafety for orthopedic applications

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Journal of Materials Science & Technology 2023年第9期140卷 58-66页

作者： Baiyan Sui Hua Lu Xin Liu Jiao Sun Department of dental Materials Shanghai Biomaterials Research and Testing CenterShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai 200011China

High-purity magnesium(HP Mg)and Mg-1ca,as representations of Mg-matrix implants produced by purifying and alloying,are employed in biomedical applications primarily because of their bioactivity and *** superiority of both degradation properties,the match between degradation and osteo-genesis in vivo,and biosafety are critical problems that will decide future purifying or alloying to construct Mg-based implants and promote clinical *** present study investigated the benefits and limitations of degradation behavior and biosafety of HP Mg and Mg-1ca according to the electro-chemical experiment,hydrogen evolution test,immersion test,and in vivo bone implantation *** results indicated that due to its Mg 2 ca phase,Mg-1ca exhibited a considerably higher corrosion current density and hydrogen production than HP Mg in ***,HP Mg and Mg-1ca display a favorable match between their degradation and the surrounding osteogenesis,resulting in no significant variation in degradation in vivo during 26 ***,the implantation and degradation of HP Mg and Mg-1ca do not result in major organ dysfunction or pathological *** work is expected to lay the foundation for future clinical translation of Mg and Mg alloy orthopedic implants.

关键词： High-purity magnesium Mg-1ca Microstructure Degradation in vitro and vivo Biosafety

Stress repair mechanism activity explains inflammation and apoptosis

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Advances in Bioscience and Biotechnology 2012年第4期3卷 459-503页

作者： Lewis S. Coleman Barnes dental Surgery Center 2626 S. Mooney Blvd Visalia Ca.

A review of modern evidence using Internet resources has identified the Stress Repair Mechanism (SRM) postulated by Hans Selye in 1951. SRM activity regulates thrombin generation to govern tissue maintenance, tissue repair, hemodynamic physiology, inflammation, and apoptosis. Thrombin utilizes ATP to energize coagulation, capillary hemostasis, chemotaxis, immune activity, mitosis, metabolism, angiogenesis, and the release of chemokines, cytokines, bradykinins, and prostaglandins that enable cell-to-cell communications, promote perfusion, loosen cell connections, and sensitize nociceptors during tissue repair. The orchestration of these diverse activities by the SRM explains the disparate elements of the inflammation syndrome, including dolor (pain), rubor (redness), calor (heat), tumor (swelling), and Functio laesa (loss of function). Inflammation resolves as tissue repair nears completion and declining SRM activity restores thrombin to maintenance levels. As thrombin levels decline below a critical threshold, repair cells undergo apoptosis and clots disintegrate. Apoptosis shrinks granulation tissues to enable wound closure. Apoptosis also facilitates embryological development. Occult systemic SRM hyperactivity due to sepsis, surgery, trauma, chemicals, pain, fear, and emotional memories causes inflammatory effects that manifest as the fever, edema, malignancy, organ disruption, eclampsia, Multi-System Organ Failure (MS-OF), Systemic Inflammatory Response Syndrome (SI-RS), Adult Respiratory Distress Syndrome (ARDS), Disseminated Intravascular Coagulation (DIC) and other pathologies.

关键词： Selye Stress Inflammation Atherosclerosis Tissue Repair Hemodynamic

Is neurotrophic factor a second language that neuron and tooth speak?

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Neural Regeneration Research 2021年第9期16卷 1803-1804页

作者： Nan Xiao Department of Biomedical Sciences Arthur A.Dugoni School of DentistryUniversity of the PacificSan FranciscoCAUSA

Neurotrophic factors are growth factors that can nourish neurons and promote neuron survival and regeneration. dental origin mesenchymal stem cells express various neurotrophic factors during tooth development and the... 详细信息

关键词： speak differentiation. dental

Evolving role of biomaterials in diagnostic and therapeutic radiation oncology

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Bioactive Materials 2020年第2期5卷 233-240页

作者： Siyu Shi Ravi Vissapragada Joseph Abi Jaoude caroline Huang Anmol Mittal Elisa Liu Jim Zhong Vivek Kumar Department of Medicine Stanford School of MedicineStanfordCA94305USA College of Medicine and Public Health Flinders UniversityAdelaideSouth AustraliaAustralia Faculty of Medicine American University of BeirutBeirutLebanon Department of Medicine Rutgers New Jersey Medical SchoolNewarkNJ07102USA Department of Radiation Oncology Emory UniversityAtlantaGA30332USA Department of Restorative Dentistry Rutgers School of Dental MedicineNewarkNJ07103USA Department of Chemical and Materials Engineering New Jersey Institute of Technology07102USA Department of Biomedical Engineering New Jersey Institute of Technology07102USA

Radiation therapy to treat cancer has evolved significantly since the discovery of ***,radiation therapy still has room for improvement in reducing side effects and improving control of *** and more effective delivery of radiation has led us to novel techniques and use of *** in combination with radiation and chemotherapy have started to appear in pre-clinical explorations and clinical applications,with many more on the *** have revolutionized the field of diagnostic imaging,and now are being cultivated into the field of theranostics,combination therapy,and tissue *** review summarizes recent development of biomaterials in radiation therapy in several application areas.

关键词： Biomaterials Theranostics Nanoparticles Radiation therapy Self-assembly

A new scorpion polypeptide enhances the binding of radiolabeled-ryanodine on ryanodine receptor in sarcoplasmic reticulum of rabbit skeletal muscle

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Chinese Science Bulletin 1997年第2期42卷 147-151页

作者： Seiko Kawano Yoshiyuki Hirayama Masayasu Hiraoka Akihiko Kuniyasu Hitoshi Nakayama Department of cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanFaculty of Pharmaceutical Science Hokkaido University Japan Faculty of Pharmaceutical Science Kumamoto University Japan

RYANODINE is a toxic alkaloid from the plant Ryania speciosa Vahl. It selectively binds to the ca2+ release channel on skeletal and cardiac heavy sarcoplasmic reticulum （HSR） and has

关键词： scorpion Buthus martensi Karsch ryanodine receptor toxic polypeptide.

Adaptation of a Biomineralization Strategy for Remineralization of Enamel and Dentin

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Journal of Wuhan University of Technology(Materials Science) 2005年第B12期20卷 60-62页

作者：梁志宏陈治清 Department of dental Materials West China College of Stomatology Sichuan UniversityChengdu 610041 China

The bio- inspired strategy of triggered release of ca^2＋ , Pi, F from prosomal compartments was used to induce rapid formation of FHA for potential dental use ： calcium and inorganic phosphate salts were separately loaded into temperature-sensitive liposome composed of 90% DPPC and 10% DMPC. When heated from the room temperature to 35- 37 ℃ , the entrapped calcium, inorganic phosphate and fl^rin released from the liposome,A mixture of ca- Pi and F-loaded liposome formed apatite. The mineral was indicated by a rapid drop in suspension PH from 7.4 approximately 6. This was illustrated by applying a liposome suspension warmed human dentin and enamel surface which resulted in deposition of apatite onto the tissue substrates.

关键词： biomimetic bio-mineralization liposome matrix vesicle

Junctional epithelium and hemidesmosomes:Tape and rivets for solving the“percutaneous device dilemma”in dental and other permanent implants

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Bioactive Materials 2022年第12期7卷 178-198页

作者： Nicholas G.Fischer Conrado Aparicio MDRCBB-Minnesota dental Research Center for Biomaterials and Biomechanics University of Minnesota16-212 Moos Tower515 Delaware St.SEMinneapolisMN55455USA Division of Basic Research Faculty of OdontologyUIC Barcelona-Universitat Internacional de CatalunyaC/.Josep Trueta s/n08195Sant Cugat del VallesBarcelonaSpain Institute for Bioengineering of catalonia(IBEC) The Barcelona Institute of Science and Technology(BIST)C/.Baldiri Reixac 10-1208028BarcelonaSpain

The percutaneous device dilemma describes etiological factors, centered around the disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant percutaneous device infection. Natural percutaneous organs, in particular their extracellular matrix mediating the “device”/epithelium interface, serve as exquisite examples to inspire longer lasting long-term percutaneous device design. For example, the tooth’s imperviousness to infection is mediated by the epithelium directly surrounding it, the junctional epithelium (JE). The hallmark feature of JE is formation of hemidesmosomes, cell/matrix adhesive structures that attach surrounding oral gingiva to the tooth’s enamel through a basement membrane. Here, the authors survey the multifaceted functions of the JE, emphasizing the role of the matrix, with a particular focus on hemidesmosomes and their five main components. The authors highlight the known (and unknown) effects dental implant - as a model percutaneous device - placement has on JE regeneration and synthesize this information for application to other percutaneous devices. The authors conclude with a summary of bioengineering strategies aimed at solving the percutaneous device dilemma and invigorating greater collaboration between clinicians, bioengineers, and matrix biologists.

关键词： Percutaneous device Percutaneous implant Hemidesmosome Junctional epithelium Bioinspired surfaces