A narrative overview of utilizing biomaterials to recapitulate the salient regenerative features of dental-derived mesenchymal stem cells

作     者：Sevda Pouraghaei Sevari Sahar Ansari Alireza Moshaverinia Sevda Pouraghaei Sevari;Sahar Ansari;Alireza Moshaverinia

作者机构：Weintraub Center for Reconstructive BiotechnologyDivision of Advanced ProsthodonticsSchool of DentistryUniversity of CaliforniaLos AngelesLos AngelesCAUSA California NanoSystems InstituteUniversity of CaliforniaLos AngelesLos AngelesCAUSA 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2021年第13卷第2期

页      面：117-128页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

主　　题：biomaterials utilizing utilize 

摘      要：Tissue engineering approaches have emerged recently to circumvent many limitations associated with current clinical *** elegant approach utilizes a natural/synthetic biomaterial with optimized physiomechanical properties to serve as a vehicle for delivery of exogenous stem cells and bioactive factors or induce local recruitment of endogenous cells for in situ tissue *** by the natural microenvironment,biomaterials could act as a biomimetic three-dimensional(3D)structure to help the cells establish their natural *** a strategy should not only employ a biocompatible biomaterial to induce new tissue formation but also benefit from an easily accessible and abundant source of stem cells with potent tissue regenerative *** human teeth and oral cavity harbor various populations of mesenchymal stem cells(MSCs)with self-renewing and multilineage differentiation *** the current review article,we seek to highlight recent progress and future opportunities in dental MSC-mediated therapeutic strategies for tissue regeneration using two possible approaches,cell transplantation and cell ***,this paper develops a general picture of current innovative strategies to employ dental-derived MSCs combined with biomaterials and bioactive factors for regenerating the lost or defective tissues and offers information regarding the available scientific data and possible applications.