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Fish-on-Chips:unveiling neural processing of chemicals in small animals through precise fluidic control

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Neural Regeneration Research 2024年第11期19卷 2351-2353页

作者： Samuel K.H.Sy Ho Ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li Ka Shing Institute of Health Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced Biomedical Instrumentation center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret K.L.Cheung Research center for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-chuen Research center of Brain Degenerative Diseases in Chinese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald Choa Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in ***,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal ***,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain ***,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much *** is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.

关键词： dealing precise sizes

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

The Implications of Artificial Intelligence on Infection Prevention and Control: Current Progress and Future Perspectives

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China CDC weekly 2024年第35期6卷 901-904页

作者： Lin Yang Shuya Lu Lei Zhou School of Nursing The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Chinese center for Disease Control and Prevention BeijingChina

The rapid advancement of artificial intelligence(AI)has significantly impacted infection prevention and control,particularly amid the coronavirus disease 2019(COVID-19)pandemic(1).AI techniques such as machine learning(ML),deep learning,and natural language processing(NLP)have successfully transformed infection prevention and control strategies(1).These technologies have enhanced our understanding of infectious diseases,facilitated disease transmission prediction,and improved public health emergency responses(2).

关键词： has such prevention

Sphingolipid inhibitor response gene GhMYB86 controls fiber elongation by regulating microtubule arrangement

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Journal of Integrative Plant Biology 2024年第9期66卷 1898-1914页

作者： Fan Xu Guiming Li Shengyang He Zhifeng Zeng Qiaoling Wang Hongju Zhang Xingying Yan Yulin Hu Huidan Tian Ming Luo College of Agronomy and Biotechnology Southwest UniversityChongqing 400715China Engineering Research center of South Upland Agriculture Ministry of EducationSouthwest UniversityChongqing 400715China Dianjiang No.1 Middle School of Chongqing Chongqing 408300China yushan No.1 Senior High School Shangrao 334700China

Although the cell membrane and cytoskeleton play essential roles in cellular morphogenesis,the interaction between the membrane and cytoskeleton is poorly *** fibers are extremely elongated single cells,which makes them an ideal model for studying cell ***,we used the sphingolipid biosynthesis inhibitor,fumonisin B1(FB1),and found that it effectively suppressed the myeloblastosis(MYB)transcription factor GhMYB86,thereby negatively affecting fiber elongation.A direct target of GhMYB86 is GhTUB7,which encodes the tubulin protein,the major component of the microtubule ***,both the overexpression of GhMYB86 and GhTUB7 caused an ectopic microtubule arrangement at the fiber tips,and then leading to shortened ***,we found that GhMBE2 interacted with GhMYB86 and that FB1 and reactive oxygen species induced its transport into the nucleus,thereby enhancing the promotion of GhTUB7 by ***,we established a GhMBE2-GhMYB86-GhTUB7 regulation module for fiber elongation and revealed that membrane sphingolipids affect fiber elongation by altering microtubule arrangement.

关键词： cotton fiber membrane sphingolipid microtubule arrangement

Research on Planning and Design of Multi-Story Prefabricated Electric Bicycle Charging Parking Lot in Urban and Rural Areas

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Journal of Architectural Research and Development 2024年第4期8卷 77-91页

作者： Liya Fang Guangzhou administrative center of Major Public Construction Projects Guangzhou 5100360China

In recent years,disorderly parking and difficult charging of electric bicycles have been challenges in urban *** rapid growth of electric bicycles is in contradiction with the lack of dedicated parking spaces and charging service facilities in towns and *** solve the issue of parking and charging electric bicycles in limited urban and rural spaces,prefabricated building technology is applied to the design of a multi-story electric bicycle parking *** multi-story prefabricated electric bicycle parking lot is utilized in urban and rural planning and design to upgrade parking facilities in old urban areas,land-constrained commercial areas,as well as counties,towns,and rural areas with inadequate municipal ***-story prefabricated electric bicycle parking lots are the application exploration of industrial buildings,and promote the high-quality development planning and construction of towns and counties and *** with the single-story metal charging station,the multi-story assembled electric bicycle parking lot has the characteristics of integrating parking and charging,being more durable and safer in structure,accommodating a large number of vehicles,and improving the space utilization rate.

关键词： Prefabricated building Electric bicycle Parking lot

Key Points and Difficulties in the Management of a New Guangzhou 12th People’s Hospital Branch

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Journal of World Architecture 2024年第3期8卷 63-71页

作者： Liya Fang Guangzhou administrative center of Major Public Construction Projects Guangzhou 510360China

During the 13th Five-Year Plan period,to improve medical and health services,the Guangzhou Municipal government invested billions in medical *** that time,Guangzhou was renewing its approval procedures for construction projects,and the COVID-19 outbreak changed the requirements of hospital *** addition to focusing more on spatial planning and layout,the integration of specialized departments,large-scale medical equipment,and numerous intelligent systems increased the complexity of hospital construction *** success of these projects often hinges on the quality of the management *** a hospital construction project manager lacks experience and an understanding of the project’s key aspects,they may struggle with organization,management,and problem-solving,leading to rework,resource waste,and *** paper uses the construction of a new Guangzhou 12th People’s Hospital branch as an example to describe the key points and difficulties in each stage of project construction and proposes solutions for the management of similar projects in the future.

关键词： Hospital construction project Project management Management essentials

Sphingolipid inhibitor response gene GhMYB86 controls fiber elongation by regulating microtubule arrangement

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Journal of Integrative Plant Biology 2024年第09期 1898-1914页

作者： Fan Xu Guiming Li Shengyang He Zhifeng Zeng Qiaoling Wang Hongju Zhang Xingying Yan Yulin Hu Huidan Tian Ming Luo College of Agronomy and Biotechnology Southwest University Engineering Research center of South Upland Agriculture Ministry of Education Southwest University Dianjiang No.1 Middle School of Chongqing yushan No.1 Senior High School

Although the cell membrane and cytoskeleton play essential roles in cellular morphogenesis, the interaction between the membrane and cytoskeleton is poorly understood. Cotton fibers are extremely elongated single cells, which makes them an ideal model for studying cell development. Here, we used the sphingolipid biosynthesis inhibitor, fumonisin B1(FB1), and found that it effectively suppressed the myeloblastosis(MYB) transcription factor Gh MYB86,thereby negatively affecting fiber elongation. A direct target of Gh MYB86 is Gh TUB7, which encodes the tubulin protein, the major component of the microtubule cytoskeleton. Interestingly, both the overexpression of Gh MYB86 and Gh TUB7 caused an ectopic microtubule arrangement at the fiber tips,and then leading to shortened fibers. Moreover, we found that Gh MBE2 interacted with Gh MYB86 and that FB1 and reactive oxygen species induced its transport into the nucleus, thereby enhancing the promotion of Gh TUB7 by Gh MYB86. Overall, we established a Gh MBE2-Gh MYB86-Gh TUB7 regulation module for fiber elongation and revealed that membrane sphingolipids affect fiber elongation by altering microtubule arrangement.

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Neuropeptide cholecystokinin:a key neuromodulator for hippocampal functions

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Neural Regeneration Research 2025年第7期20卷 1991-1992页

作者： Fengwen Huang Stephen Temitayo Bello Department of Neuroscience City University of Hong KongKowloon TongHong Kong Special Administrative RegionChina center for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong Special Administrative RegionChina

Spatial memory is crucial for survival within external surroundings and wild *** hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and *** neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal ***(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target *** instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety ***,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.

关键词： abundant functions modulator

Neutrophil-to-lymphocyte ratio associated with renal function in type 2 diabetic patients

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World Journal of Clinical Cases 2024年第14期12卷 2308-2315页

作者： Jin-Li Gao Jue Shen Li-Ping Yang Li Liu Kai Zhao Xiao-Rong Pan Lei Li Ji-Ji Xu Department of Prevention and Health Care Community Health Service Center of Miaohang TownShanghai 200443China Department of Prevention and Health Care Community Health Service Center of Songnan TownShanghai 200434China Department of General Practice Community Health Service Center of Songnan TownShanghai 200434China Department of administrative Community Health Service Center of Songnan TownShanghai 200434China

BACKGROUND Type 2 diabetes mellitus(T2DM)is a leading risk factor for the development and progression of chronic kidney disease(CKD).However,an accurate and con-venient marker for early detection and appropriate management of CKD in in-dividuals with T2DM is *** studies have demonstrated a strong correlation between the neutrophil-to-lymphocyte ratio(NLR)and ***-theless,the predictive value of NLR for renal damage in type 2 diabetic patients remains *** study included 1040 adults aged 65 or older with T2DM from Shanghai's Community Health Service *** total number of neutrophils and lym-phocytes was detected,and NLR levels were *** was defined as an estimated glomerular filtration rate≤60 mL/min/1.73 m².Participants were di-vided into four groups based on NLR *** clinical data and biochemical characteristics were compared among groups.A multivariate logistic regression model was used to analyze the association between NLR levels and *** Significant differences were found in terms of sex,serum creatinine,blood urea nitrogen,total cholesterol,and low-density lipoprotein cholesterol among patients with T2DM in different NLR groups(P<0.0007).T2DM patients in the highest NLR quartile had a higher prevalence of CKD(P for trend=0.0011).Multivariate logistic regression analysis indicated that a high NLR was an independent risk factor for CKD in T2DM patients even after adjustment for important clinical and pathological parameters(P=0.0001,odds ratio=1.41,95%confidence intervals:1.18-1.68).CONCLUSION An elevated NLR in patients with T2DM is associated with higher prevalence of CKD,suggesting that it could be a marker for the detection and evaluation of diabetic kidney disease.

关键词： Type 2 diabetes mellitus Neutrophil-to-lymphocyte ratio Chronic kidney disease Logistic regression Diabetes mellitus