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Pooled analysis of efficacy of the fourth mRNA-based COVID-19 vaccine dose in eliciting anti-SARS-CoV-2 serum antibody response in the general immunocompetent population

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infectious diseases Research 2023年第2期4卷 1-5页

作者： Giuseppe Lippi Camilla Mattiuzzi Brandon Michael Henry Section of Clinical Biochemistry and School of Medicine University of VeronaVerona 37134Italy Service of Clinical Governance Provincial Agency for Social and Sanitary Services(APSS)Trento 38123Italy Clinical Laboratory Division of Nephrology and HypertensionCincinnati Children’s Hospital Medical CenterCincinnati 45229USA

Objective:Since the opportunity of widespread administration of the fourth mRNA-based coronavirus disease 2019(COVID-19)vaccine dose remains controversial,this article provides a pooled analysis of the efficacy of the second COVID-19 mRNA-based homologous vaccine booster in eliciting anti-SARS-CoV-2 serum antibody response in general immunocompetent ***:We conducted a digital search in Medline using the keywords"fourth dose"or"second booster"and"antibodies"and"COVID-19"or"SARS-CoV-2"and"BNT162b2"or"mRNA-1273",to identify all clinical studies which evaluated the anti-SARS-CoV-2 serum antibody response after the fourth mRNA-based COVID-19 homologous vaccine dose administration in general immunocompetent populations compared to the response seen before its administration and after the first ***:Four studies totaling 571 recipients of the second mRNA-based COVID-19 vaccine booster were finally included in our *** weighted mean difference(WMD)ratio of anti-SARS-CoV-2 serum antibodies levels measured after and before administration of the fourth vaccine dose was 9.7(95%CI,6.5-12.9)in those receiving BNT162b2 and 12.0(95%CI,5.8-18.2)in those receiving mRNA-1273,*** WMD ratio of anti-SARS-CoV-2 serum antibodies levels measured at the peak of the fourth and third vaccine doses was 1.4(95%CI,1.2-1.7)in those receiving BNT162b2 and 1.9(95%CI,1.5-2.4)in those receiving mRNA-1273,***:Our data confirm the efficacy of the fourth mRNA-based COVID-19 vaccine dose in restoring a satisfactory level of anti-SARS-CoV-2 serum antibodies,though such effectiveness seems only marginally superior to that of the first booster.

关键词： SARS-CoV-2 COVID-19 vaccine booster

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Impact of Environmental Pollution on the Frequency of Seizures in Children with Sickle Cell disease (CH Kenitra Morocco)

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Advances in Microbiology 2017年第2期7卷 149-157页

作者： Mouden Samira Ahami Ahmad Omar Mohamd Khorassani Dakir Zahra Sadek Sanae Department of Biology Unit of Clinical Neuroscience and Nutritional Health Faculty of Human Biology and Population Health University Ibn Tofail Kenitra Morocco Laboratory Services of Medical Analysis Regional Hospital Kenitra Center Morocco Unit of Hematology and Pediatric Oncology Ibn Sina Hospital Kenitra Morocco Laboratory Environnemets and Renewable Energy Faculty of Science University Ibn Tofail of Kenitra Kenitra Morocco

The sickle cell disease sickle cell anemia called Expired aussi is a genetic disease Caused by abnormal hemoglobin. The pediatric ward of the provincial hospital kenitra recorded a workforce of 164 children with sickle cell disease over a period of twenty four months (June 2010-June 2012). On average seven to eight (7 to 8) children are born per year with this disease. The majority of these children are admitted to the pediatric ward and have an increased susceptibility to infections. To identify socio-economic and environmental factors in the care of children and their families. The study group consists of 60 children aged 7 - 14 years. Clinical and analytical information is obtained from records and doctors during consultations of these patients. The results show that 64% of these children are from rural areas against 30% of children of urban origin, while 6% live in suburban areas, however 68% of these children use septic false. In parallel they consume well water. Clinical examination and white blood cell count revealed a prevalence of 76% for fever cases reviews some of qui-have ticemia September, 43% for leukocytosis. Moreover, we noted that diarrhea is very common in this sample. Parenting was made bacteriological examinations of well water consumed by these children. In conclusion, the present study showed a significant combination entre les frequency of sickle cell crises infectious presented by the children studied and the environmental quality of life and family in the child qui develops.

关键词： Sickle Cell Anemia Child Infection Pediatrics

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Fighting against the common enemy of COVID-19: a practice of building a community with a shared future for mankind

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infectious diseases of Poverty 2020年第2期9卷 8-13页

作者： Xu Qian Ran Ren Youfa Wang Yan Guo Jing Fang Zhong-Dao Wu Pei-Long Liu Tie-Ru Han 无 School of Public Health/Global Health Institute Fudan UniversityShanghai 200032China Global Health Center Dalian Medical UniversityDalian 116021China Global Health Institute School of Public HealthXi’an Jiaotong UniversityXi’an 710061China Global Health Center School of Public HealthBeijing UniversityBeijing 100871China Kunming Medical University Yunnan 650500China Zhongshan School of Medicine Sun Yat-Sen UniversityGuangzhou 510080China Society of Global Health Chinese Preventive Medicine AssociationBeijing 100013China Steering Committee Society of Global HealthChinese Preventive Medicine Association

The outbreak of coronavirus disease 2019(COVID-19)has caused more than 80813 confirmed cases in all provinces of China,and 21110 cases reported in 93 countries of six continents as of 7 March 2020 since middle December *** to biological nature of the novel coronavirus,named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with faster spreading and unknown transmission pattern,it makes us in a difficulty position to contain the disease transmission *** date,we have found it is one of the greatest challenges to human beings in fighting against COVID-19 in the history,because SARS-CoV-2 is different from SARS-CoV and MERS-CoV in terms of biological features and transmissibility,and also found the containment strategies including the non-pharmaceutical public health measures implemented in China are effective and *** order to prevent a potential pandemic-level outbreak of COVID-19,we,as a community of shared future for mankind,recommend for all international leaders to support preparedness in low and middle income countries especially,take strong global interventions by using old approaches or new tools,mobilize global resources to equip hospital facilities and supplies to protect noisome infections and to provide personal protective tools such as facemask to general population,and quickly initiate research projects on drug and vaccine *** also recommend for the international community to develop better coordination,cooperation,and strong solidarity in the joint efforts of fighting against COVID-19 spreading recommended by the joint mission report of the WHO-China experts,against violating the International Health Regulation(WHO,2005),and against stigmatization,in order to eventually win the battle against our common enemy—COVID-19.

关键词： COVID-19 SARS-CoV-2 Outbreak Pandemic Fighting Preparedness International health regulation Quarantine

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Current Advances of Innate and Adaptive Immunity in Acute-on-Chronic Hepatitis B Liver Failure

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infectious diseases & Immunity 2022年第2期2卷 113-121页

作者： Liyuan Wang Yuchen Fan Department of Hepatology Qilu Hospital of Shandong UniversityJinan 250012China Department of Immunology School of Basic Medical ScienceCheeloo College of MedicineShandong UniversityJinan 250012China

Acute-on-chronic hepatitis B liver failure(ACHBLF)is a term used to define the acute deterioration of liver function that occurs in patients with chronic hepatitis B virus infection or hepatitis B virus-related liver *** specific pathogenesis of ACHBLF is still not completely *** research has shown that an intense systemic inflammation is involved in the development of acute-on-chronic liver failure(ACLF).Meanwhile,a subsequent immune paresis over the course of ACLF favors the development of infection and *** in both the innate and adaptive immunity is the notable feature of *** dysregulated immune responses play a crucial role in disease progression and potentially drive organ failure and mortality in *** this review,we highlight the current knowledge of innate and adaptive immune cells in ACHBLF.

关键词： Acute-on-chronic liver failure Adaptive immunity Hepatitis B virus Immune cells Innate immunity

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Distribution of the COVID-19 epidemic and correlation with population emigration from Wuhan,China

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Chinese Medical Journal 2020年第9期133卷 1044-1050页

作者： Ze-Liang Chen Qi Zhang Yi Lu Zhong-Min Guo Xi Zhang Wen-Jun Zhang Cheng Guo Cong-Hui Liao Qian-Lin Li Xiao-Hu Han Jia-Hai Lu One Health Center School of Public HealthSun Yat-sen UniversityGuangzhouGuangdong 510080China Key Laboratory of Livestock infectious diseases in Northeast China Ministry of EducationShenyang Agricultural UniversityShenyangLiaoning 110866China College of Animal Science and Veterinary Medicine Shenyang Agricultural UniversityShenyangLiaoning 110866China Department of Health Law Policy and ManagementSchool of Public HealthBoston UniversityBostonMA 02215USA Animal Experiment Center Sun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Biological Science and Technology School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510080China Center for Infection and Immunity Mailman School of Public HealthColumbia UniversityNew YorkNY 10032USA

Background:The ongoing new coronavirus pneumonia(Corona Virus disease 2019,COVID-19)outbreak is spreading in China,but it has not yet reached its *** million people emigrated from Wuhan before lockdown,potentially representing a source of virus *** case distribution and its correlation with population emigration from Wuhan in the early stage of the epidemic is of great importance for early warning and for the prevention of future ***:The official case report on the COVID-19 epidemic was collected as of January 30,*** and location information on COVID-19 cases was extracted and analyzed using ArcGIS and WinBUGS *** on population migration from Wuhan city and Hubei province were extracted from Baidu Qianxi,and their correlation with the number of cases was ***:The COVID-19 confirmed and death cases in Hubei province accounted for 59.91%(5806/9692)and 95.77%(204/213)of the total cases in China,*** spot provinces included Sichuan and yunnan,which are adjacent to *** time risk of Hubei province on the following day was 1.960 times that on the previous *** number of cases in some cities was relatively low,but the time risk appeared to be continuously *** correlation coefficient between the provincial number of cases and emigration from Wuhan was up to *** lockdown of 17 cities in Hubei province and the implementation of nationwide control measures efficiently prevented an exponential growth in the number of ***:The population that emigrated from Wuhan was the main infection source in other cities and *** cities with a low number of cases showed a rapid increase in case *** to the upcoming Spring Festival return wave,understanding the risk trends in different regions is crucial to ensure preparedness at both the individual and organization levels and to prevent new outbreaks.

关键词： Corona Virus disease 2019 Temporal Spatial Distribution Outbreak

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Clinical Distribution and Drug Resistance of Acinetobacter baumannii in a hospital from 2019 to 2021

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Journal of Clinical and Nursing Research 2023年第3期7卷 124-129页

作者： Wei Liu Yiminghui Long Yu Liu Xu Zhou Hunan University of Medicine College of NursingHuaihua 418000Hunan ProvinceChina Department of Laboratory Medicine Huaihua First People’s HospitalHuaihua 418000Hunan ProvinceChina

Objective:To analyze the clinical distribution and drug resistance of Acinetobacter baumannii(AB)and provide reference for the treatment of AB ***:AB isolated from clinical specimens of Huaihua First People’s hospital from 2019 to 2021 were collected and identified by VITEK 2 Compact,an automated microbial identification and susceptibility testing system,in which drug sensitivity test was also *** was used for statistical ***:Among the 1,311 AB strains,81.16%(1,064 strains)were from sputum samples,and the departments with the highest detections rates of AB were neurosurgery(24.33%),intensive care(15.48%)and infectious disease(11.44%).The drug sensitivity test showed that the resistance rate of 1,311 AB strains to compound sulfamethoxazole and amikacin was 28.38%and 20.54%,respectively,and the resistance rate to 10 other kinds of common antibiotics was more than 40%.Conclusion:The 1,311 AB strains isolated were widely distributed in clinical settings and had strong resistance to commonly used ***,it is necessary to strengthen the monitoring of pathogens and drug resistance,formulate reasonable and effective infection control measures,and ensure that antibiotics are used in a reasonable manner.

关键词： Acinetobacter baumannii Drug resistance Drug sensitivity test

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